Morphinan derivative and its pharmaceutical applications

ABSTRACT

A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I,an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective kappa-opioid agonist, allowing it to be used as a useful analgesic and diuretic.

This application is a continuation of co-pending application Ser. No. 08/108,643, filed on Feb. 10, 1997. Application Ser. No. 08/108,643 is the national phase of PCT International Application No. PCT/JP93/00800 filed on Jan. 22, 1993 under 35 U.S.C. §371. The entire contents of each of the above-identified applications are hereby incorporated by reference.

TECHNICAL FIELD

The present invention relates to an analgesic and diuretic having as its active ingredient a morphinan derivative or a pharmacologically acceptable acid salt thereof.

BACKGROUND ART

Morphine has long been known as a powerful analgesic having a morphinan skeleton, and is widely used even at present. However, this drug has serious side effects that present clinical problems, including drug dependence, action that suppresses respiration and action that suppresses smooth muscle movement (constipation). Thus, there is a need for a powerful analgesic that acts on the central nervous system and that also can be used safely.

In addition, it has also been reported that drugs that act on opioid receptors effect urination (J. D. Leander, J. Pharmacol. Exp. Ther., 227, 35 (1983)), and thus, the effective use of that action is also desired.

DISCLOSURE OF THE INVENTION

The existence of opioid receptors has been clearly established as receptors involved in analgesic action on the central nervous system. Moreover, these receptors are known to be able to classified into the three types, μ, δ and κ. In addition, σ receptors are also known to demonstrate psychotomimetics. Those agonists having affinity for these κ-receptors or δ-receptors have been shown to have strong analgesic activity, while not demonstrating serious side effects that present clinical problems, such as drug dependence, action that suppresses respiration and action that suppresses smooth muscle movement, that are observed in the case of morphin and so forth, which are μ-receptor agonists. In addition, the psychotomimetics observed in existing κ-receptor agonists are reported to be caused by the affinity to σ-receptors. Moreover, κ-receptor agonists do not demonstrate cross tolerance with μ-receptor agonists such as morphin. Analgesics free of such side effects having a high degree of usefulness since they can be applied in not only the control of pain in patients having post-operative pain and cancer patients suffering from cancer, but can also be widely applied for general pain. In addition, the absence of cross tolerance indicates that these analgesics are effective even in patients that have developed tolerance to analgesics such as morphin. Therefore, the object of the present invention is to provide a κ-receptor agonist or δ-receptor agonist that has powerful analgesic action while not having serious side effects like those of morphin, not having cross tolerance with morphin and so forth, and not demonstrating any affinity whatsoever for σ-receptors. In addition, another object of the present invention is to provide a useful diuretic that takes advantage of the effects of opioid action drugs on urination.

As a result of earnest studies to solve the above-mentioned problems, the inventors of the present invention found that the morphinan derivatives indicated by the below formula (I) is a compound that demonstrates analgesic action and diuretic action having the excellent characteristics described above, thus leading to completion of the present invention.

Namely, the present invention relates to a morphinan derivative represented with general formula (I) below or pharmacologically acceptable acid salt thereof, its production process as well as its pharmaceutical applications:

[wherein,

represents a single or double bond; R¹ represents an alkyl group having 1-5 carbon atoms, a cycloalkylalkyl group having 4-7 carbon atoms, a cycloalkenylalkyl group having 5-7 carbon atoms, an aryl group having 6-12 carbon atoms, an aralkyl group having 7-13 carbon atoms, an alkenyl group having 4-7 carbon atoms, an allyl group, a furan-2-ylalkyl group having 1-5 carbon atoms, or a thiophen-2-ylalkyl group having 1-5 carbon atoms; R² represents a hydrogen atoms, a hydroxy group, a nitro group, an alkanoyloxy group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkyl group having 1-5 carbon atoms, or —NR⁹R¹⁰ wherein R⁹ represents a hydrogen atom or an alkyl group having 1-5 carbon atoms, and R¹⁰ represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, or —C(═O)R¹¹ wherein R¹¹ represents a hydrogen atom, a phenyl group or an alkyl group having 1-5 carbon atoms; R³ represents a hydrogen atom, a hydroxy group, an alkanoyloxy group having 1-5 carbon atoms, or an alkoxy group having 1-5 carbon atoms; A represents —XC(═Y)—, —XC(═Y)Z—, —X—, —XSO₂—, or —OC(OR⁴)R⁴— (where, X, Y and Z each independently represent NR⁴, S or O wherein R⁴ represents a hydrogen atom, a straight-chain or branched chain alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms, and wherein R⁴ may be identical or different); B represents a valence bond, a straight-chain or branched chain alkylene group having 1-14 carbon atoms (which may be substituted with at least one type of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, and wherein 1 to 3 methylene groups may be replaced with carbonyl groups), an acyclic unsaturated hydrocarbon containing from 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms (which may be substituted with at least one substituent group selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, and wherein from 1 to 3 methylene groups may be replaced with carbonyl groups), or a straight-chain or branched chain saturated or unsaturated hydrocarbon group containing from 1 to 5 thioether, ether and/or amino bonds and having 1-14 carbon atoms (wherein hetero atoms are not bonded directly to A, and 1 to 3 methylene groups may be replaced with carbonyl groups); R⁵ represents a hydrogen atom or an organic group having the basic skeleton of (formula 1) (which may be substituted with at least one or more substituent groups selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, an isothiocyanate group, a trifluoromethyl group and a methylenedioxy group),

(Formula 1) Organic Group Represented by R⁵ (Formula 1—1)

R⁶ represents a hydrogen atom; R⁷ represents a hydrogen atom, a hydroxy group, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, or R⁶ and R⁷ together represent —O—, —CH₂— or —S—; R⁸ represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, or an alkanoyl group having 1-5 carbon atoms, and the general formula (I) includes the (+) form, (−) form and (±) form].

DETAILED DESCRIPTION

Here, preferable examples of R¹ include an alkyl group having 1-5 carbon atoms, a cycloalkylmethyl group having 4-7 carbon atoms, a cycloalkenylmethyl group having 5-7 carbon atoms, a phenylalkyl group having 7-13 carbon atoms, an alkenyl group having 4-7 carbon atoms, an allyl group, a furan-2-yl-alkyl group having 1-5 carbon atoms and a thiophen-2-yl-alkyl group having 1-5 carbon atoms, while particularly preferable examples of R¹ include methyl, ethyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclopentenylmethyl, cyclohexenylmethyl, benzyl, phenethyl, trans-2-butenyl, 2-methyl-2-butenyl, allyl, furan-2-yl-methyl and thiophen-2-yl-methyl groups.

Preferable examples of R² include a hydrogen atom, and hydroxy, nitro, acetoxy, methoxy, methyl, ethyl, propyl, amino, dimethylamino, acetylamino and benzoylamino groups, while particularly preferable examples include a hydrogen atom, and hydroxy, nitro, acetoxy, methyl and dimethylamino groups.

Preferable examples of R³ include a hydrogen atom, and hydroxy, acetoxy and methoxy groups.

Preferable examples of A include —NR⁴C(═O)—, —NR⁴C(═S)—, —NR⁴C(═O)O—, —NR⁴C(═O)NR⁴—, —NR⁴C(═S)NR⁴—, —NR⁴C((═O)S—, —OC((═O)—, —OC(═O)O—, —SC(═O)—, —NR⁴—, —O—, —NR⁴SO₂— and —OSO₂—, while particularly preferable examples include —NR⁴C(═O)—, —NR⁴C(═S)—, —NR⁴C(═O) O—, —NR⁴C(═O)NR⁴—, —NR⁴C(═S)NR⁴— and —NR⁴SO₂—.

Preferable examples of R⁴ include a hydrogen atom, a straight-chain or branched alkyl group having 1-5 carbon atoms and a phenyl group, while particularly preferable examples include a straight-chain or branched alkyl group having 1-5 carbon atoms, and particularly methyl, ethyl, propyl, isopropyl, butyl and isobutyl groups.

Preferable examples of B include —(CH₂)n— (n=0-6), —(CH₂)n—C(═O)— (n=1-4), —CH═CH—(CH₂)n— (n=0-4), —C≡C—(CH₂)n— (n=0-4), —CH₂—O—, —CH₂—S—, —CH₂—O—(CH₂)₂—O—(CH₂)₂—, —CH₂—O——CH₂—NH—CH₂—O—CH₂— and —CH₂—O—CH₂—S—CH₂—O—CH₂—, while particularly preferable examples include —(CH₂)n— (n=0-6), —CH═CH—(CH₂)n— (n=0-4), —C≡C—(CH₂)n— (n=0-4), —CH₂—O— and —CH₂—S—. Preferable examples of R⁵ include a hydrogen atom and an organic group having the basic skeleton indicated in (formula 1-1) (which may be substituted with at least one or more substituent groups selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, an amino group, a nitro group, a cyano group, an isothiocyanate group and a trifluoromethyl group),

while particularly preferable examples include, a hydrogen atom and phenyl, 3,4-dichlorophenyl, 4-chlorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 4-fluorophenyl, 3-fluorophenyl, 2-fluorophenyl, 4-bromophenyl, 3-bromophenyl, 2-bromophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitrophenyl, 4-trifluoromethylphenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 4-methylphenyl, 3-methylphenyl, 2-methylphenyl, 4-methoxyphenyl, 3-methoxyphenyl, 2-methoxy, 3-furanyl, 2-furanyl, 3-thienyl, 2-thienyl, cyclopentyl and cyclohexyl groups. But naturally the present invention is not limited to these examples.

Preferable examples of pharmacologically preferable acid addition salts include, but are naturally not limited to, inorganic acid salts such as hydrochloride, sulfate, nitrate, hydrobromide, hydroiodide and phosphate; organic carboxylates such as acetate, lactate, citrate, oxalate, glutarate, malate, tartrate, fumarate, mandelate, benzoate and phthalate; and, organic sulfonates such as methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate and camphorsulfonate, while particularly preferable examples include hydrochloride, hydrobromate, phosphate, tartrate and methanesulfonate.

Among the compounds of the general formula (I) of the present invention, compound 1

wherein

is a single bond, R¹ is a cyclopropylmethyl group, R² and R³ are hydroxy groups, A is α-NR⁴C(═O)—, R⁴ is a methyl group, B is —CH₂—, R⁵ is 3,4-dichlorophenyl, R⁶ and R⁷ are together —O— and R⁸ is a hydrogen atom is named 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamide)morphinane.

In accordance with the above nomenclature system, concrete examples of the compound of the present invention are as follows:

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmetyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4.5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmetyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14βhydroxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14βhydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14βhydroxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-allyl-4,5α-epoxy-14βhydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14βhydroxy-6α-(N-methyl-3,4-dichlorophenylacetoamido)morphinan,

17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5(α-epoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-actoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylcinamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmetyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14βhydroxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5αepoxy-3,14β-diacetoxy-6α-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylphenylmethanesulfonamido)-morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmetyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-metyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-metyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-metyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan,

17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmetyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinane, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan,

17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-62-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-metylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-60-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-60-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)-morphinan,

17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylbenzyloxycarbamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14-dihydroxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan,

17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylbenzyloxycarbamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan,

17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylphenylmethanesulfonamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3,4-dichlorophenylacetamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylbenzyloxycarbamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutylphenylmethanesulfonamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorobenzamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorobenzamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorobenzamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorobenzamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-ethyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-ethyl-3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-ethyl-3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-ethyl-3,4-dichlorophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropionamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropionamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(5-chlorobenzo[b]thienyl)acetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(5-chlorobenzo[b]thienyl)acetamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(5-chlorobenzo[b]thienyl)acetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(5-chlorobenzo[b]thienyl)acetamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcyclohexylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcyclohexylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcyclohexylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcyclohexylacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-bromophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-bromophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-benzo[b]thienylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-benzo[b]thienylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-benzo[b]thienylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-benzo[b]thienylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorocinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorocinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-bromophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-bromophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(R)-N-methyl-2-phenylpropionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(R)-N-methyl-2-phenylpropionamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(R)-N-methyl-2-phenylpropionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(R)-N-methyl-2-phenylpropionamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(R)-N-methylmethoxyphenylacetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(R)-N-methylmethoxyphenylacetamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(R)-N-methylmethoxyphenylacetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(R)-N-methylmethoxyphenylacetamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(S)-N-methylmethoxyphenylacetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(S)-N-methylmethoxyphenylacetamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(S)-N-methylmethoxyphenylacetamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(S)-N-methylmethoxyphenylacetamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3,4-dichlorophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(3,4-dichlorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(3,4-dichlorophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-difluorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-difluorophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-difluorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-difluorophenylacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylphenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylphenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylphenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylphenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(S)-N-methyl-2-phenylpropionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(S)-N-methyl-2-phenylpropionamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(S)-N-methyl-2-phenylpropionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(S)-N-methyl-2-phenylpropionamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-N-2-(3,4dichlorophenyl)ethylamino]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-N-2-(3,4-dichlorophenyl)ethylamino]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-N-2-(3,4-dichlorophenyl)ethylamino]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-N-2-(3,4-dichlorophenyl)ethylamino]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-nitrophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-nitrophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-nitrophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-nitrophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-aminophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-aminophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-aminophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-aminophenylacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcyclohexylcarboxyamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylcyclohexylcarboxyamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcyclohexylcarboxyamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylcyclohexylcarboxyamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-phenylbutyroamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-phenylbutyroamido)) -morphinan, 17-cyclopropylmethyl -4,5α-epoxy-3,14β-dihydroxy-6β(N-methyl-4-phenylbutyroamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-phenylbutyroamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14βdihydroxy-6α-(N-methyl-2-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-bromophenylacetamido)) -morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-bromophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-bromophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-6-phenylhexanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-6-phenylhexanamido)-morphinan, 17-cyclopropylmethyl -4,5α-epoxy-3,14βdihydroxy-6β-(N-methyl-6-phenylhexanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β(N-methyl-6-phenylhexanamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14βdihydroxy-6α-(N-methyl-3-fluorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14βdihydroxy-6α-(N-methyl-3-fluorophenylacetamido)morphinan, 17-cyclopropylmethyl -4,5α-epoxy-3,14β-dihydroxy-60(N-methyl-3-fluorophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β(N-methyl-3-fluorophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-N′-(3,4-dichlorophenyl)ureido]morphinan, 17-allyl-4,5α-epoxy-3,14βdihydroxy-6α-[N-methyl-N′-(3,4-dichlorophenyl)ureido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β[N-methyl-N′-(3,4-dichlorophenyl)ureido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-N′-(3,4-dichlorophenyl)ureido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-N′-benzylureido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-N′-benzylureido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-N′-benzylureido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-N′-benzylureido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-nitrophenylacetamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-nitrophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-nitrophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-nitrophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-pyridylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-pyridylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-pyridylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-pyridylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-thienyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-thienyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-thienyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-thienyl)acrylamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylthiophenoxyacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylthiophenoxyacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylthiophenoxyacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylthiophenoxyacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenoxyacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenoxyacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenoxyacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylphenoxyacetamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-nitrobenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-nitrobenzyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-nitrobenzyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-nitrobenzyloxycarbamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-pyridylmethoxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-pyridylmethoxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-pyridylmethoxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-pyridylmethoxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylmethane-sulfonamido)-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylmethane-sulfonamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylmethanesulfonamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylmethanesulfonamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-N′-benzylthioureido)morphinan, 17-ally-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-N′-benzylthioureido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-N′-benzylthioureido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-N-methyl-N′-benzylthioureido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylhexanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylhexanamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylhexanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylhexanamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylheptanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylheptanamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-69-(N-methylheptanamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylheptanamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-aminophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-aminophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-aminophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-aminophenylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-pyridylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-pyridylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-pyridylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-pyridylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-β-pyridyl)propionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-β-pyridyl)propionamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(3-pyridyl)propionamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(3-pyridyl)propionamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3-phenylpropioyloxy)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3-phenylpropioyloxy)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(3-phenylpropioyloxy)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(3-phenylpropioyloxy)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[2-(3-furyl)ethenylsulfonyloxy]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[2-(3-furyl)ethenylsulfonyloxy]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[2-(3-furyl)ethenylsulfonyloxy]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[2-(3-furyl) ethenylsulfonyloxy]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropiolamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido) morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)-morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-methyl-trans-3-β-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-trans-3-β-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido) morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)-morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido) morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-methyl-trans-3-3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-methyl-trans-3-3-furyl)acrylamido]-morphinan,

17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido) morphinan,

17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-phenylpropiolamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-phenylpropiolamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]-morphinan,

b 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphin, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethyl -cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan,

17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-phenylpropiolamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropiolamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan,

17-methyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-68-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)) morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)-morphinan,

17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-30 methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan,

17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)-morphinan,

17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylainido]morphinan,

17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α- epoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-14β-acetoxy-6β- [N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)-morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl) acrylamido] morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamainido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6F-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)-morphinan,

17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-methoxy-14β-acetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-4-trifluoromethylcinnamaido)morphinan, 17-phenethyl-4,5α-epoxy-3-acetoxy-14β-hydroxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-4-trifluoromethyl-cinnamamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-4-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-phenylpropiolamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-cyclohexylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-cyclohexylpropionamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-cyclohexylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-cyclohexylpropionamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbutyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbutyloxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbutyloxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbutyloxy-carbamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-isothiocyanatophenylacetamido)-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-isothiocyanatophenylacetamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-isothiocyanatophenylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-isothiocyanatophenylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-hexenamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-hexenamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-hexenamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-hexenamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-fluorocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-fluorocinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-fluorocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-fluorocinnamamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methoxycinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methoxycinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methoxycinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methoxycinnamamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-cyclopentylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-cyclopentylpropionamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-cyclopentylpropionamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N- methyl-2-cyclopentylpropionamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-naphthamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-naphthamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-naphthamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-naphthamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-nitrocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-nitrocinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-nitrocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-nitrocinnamamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-methoxyethoxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-methoxyethoxycarbamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-methoxyethoxycarbamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-methoxyethoxycarbamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-trans-3-cyclohexylacrylamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-trans-3-cyclohexylacrylamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-trans-3-cyclohexylacrylamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-trans-3-cyclohexylacrylamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzoylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbenzoylacetamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzoylacetamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylbenzoylacetamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(2-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(2-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(2-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(2-furyl)acrylamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-trifluoromethylcinnamamido)morphinan, 17-allyl-4, 5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-2-trifluoromethylcinnamamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-isothiocyanatocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-isothiocyanatocinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-isothiocyanatocinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-isothiocyanatocinnamamido)morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α- (N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl) -propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl) -propiolamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-methylcinnamamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl) -propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethyl -phenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-methyl-3-(4-trifluoromethyl-phenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14α-dihydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α- (N-isobutyl-3-methylcinnamainido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α- (N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethyl-phenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α- N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolainido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6α- [N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6α-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-60-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-methylcinnamamido)-morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-methylcinnaimamido) morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β- [N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-methyl-3-methylcinnamnido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-methylcinnamamnido)morphinan, 17 -cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α(-epoxy-14β-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β- acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-6β[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-acetoxy-3-methoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17 -cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-isobutyl-3-methylcinnanamido)-morphinan, 17-allyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-14β-hydroxy-3-acetoxy-6β- [N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-3-(4-triflucromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-3- (4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-(N-isobutyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-diacetoxy-6β-[N-isobutyl-3-(4-trifluoromethylphenyl)propiolamido] morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(3-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(3-trifluoromethylphenyl)propiolamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(3-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α(-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(3-trifluoromethylphenyl)-propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(2-thienyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(2-thienyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3- (2-thienyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(2-thienyl)acrylamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-methyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-trans-3-(3-furyl)-acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-methylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3-methylcinnamamido)-morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-60-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-3,14β-dihydroxy-6α- (N-methyl-3-methylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17 -phenethyl-3,14-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6α- (N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-methylcinnamamido)-morphinan,

17-allyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-phenethyl-3,14β-dihydroxy-4-methoxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan,

17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan,

17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-( N-methyl-3-methylcinnamamido)morphinan, 17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3- (4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-methylcinnamamido)-morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-trans-3-(3-furyl)acrylaraido]-morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-nitro-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β- [N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-trifluoromethylcinnamnamido)morphinan,

17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido] morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-dimethylamino-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-methylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-methylcinnamamido)-morphinan, 17-allyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan,

14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 14β,17-dimethyl-4,5α-epoxy-3-hydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-(N-methyl-3-methylcinnamamido)morphinan,

17-phenethyl-4,5α-epoxy-3-hydroxy-14β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)-morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-allyl-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)-propiolamido]morphinan, 17-methyl-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan,

17-methyl-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-methyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-phenethyl-3,14β-dihydroxy-4-methoxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-3,14β-dihydroxy-4-methoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)-morphinan,

5β,17-dimethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-phenethyl-4,5α-epoxy-3,14β-dihydroxy-5β-methyl-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan,

17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethyl-cinnamamido)morphinan, 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan,

17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)-morphinan, 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-allyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan,

17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)-morphinan, 17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]-morphinan, 17-methyl-7, 8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, 17-methyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]-morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan, 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3-methylcinnamamido)morphinan, and 17-phenethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido]morphinan.

However, the present invention is not limited to these examples. Furthermore, the compounds of the present invention include the (+), (−) and (±) forms.

The compounds of general formula (I) of the present invention can be obtained, specifically, according to the methods described below.

Among the compounds represented by the general formula (I) of the present invention, those wherein A is —XC(═Y)—, —XC(═Y)Z— or —XSO₂— (wherein X represents NR⁴ or O, Y represents O or S, Z represents O, NH or S, and R⁴ is the same as previously defined) can be obtained, specifically, according to the methods described below.

In general, as shown in Chart 1, said compounds can be obtained by condensing a carboxylic acid derivative represented by the general formula (III) (wherein B and R⁵ are the same as previously defined), a formic acid derivative represented by the general formula (IV) (wherein Z, B and R⁵ are the same as previously defined), an isocyanic acid or isothiocyanic acid derivative represented by the general formula (V) (wherein B and R⁵ are the same as previously defined) or a sulfonic acid derivative represented by the general formula (VI) (wherein B and R⁵ are the same as previously defined), with a 6-amino or 6-hydroxy compound represented by the general formula (II) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined, and E represents NHR⁴ (wherein R⁴ is the same as previously defined) or OH).

The 6-amino and 6-hydroxy compound used in this condensation can be obtained, specifically, by the processes described below.

As shown in Chart 2, a 6α-amino compound represented by the general formula (IIaαl) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously described, and R⁴ represents a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms) is obtained by mixing a 6-keto compound represented the general formula (VIIa) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) and a primary amine represented by the general formula (VIII) (wherein R⁴ is the same as previously defined) in a solvent and hydrogenating in the presence of suitable amounts of acid and metal catalyst, or reducing with a metal hydride. reducing agent in the presence of acid. The hydrogenation reaction is more preferable in order to obtain the α-amino isomer with high selectivity. However, although the ratio varies according to the substrate, in the case of reduction using a metal hydride reducing agent, both the α form and β isomer are obtained simultaneously. Thus, this method is preferable in that it makes it possible to obtain a compound having the desired stereochemistry by using ordinary separation and purification techniques. In addition, the method in which the amine is obtained is also useful in the case of substrates having functional groups, such as olefins and so on, that react under hydrogenation conditions.

In the case of reduction using a hydrogenation reaction, 1-30 equivalents, and preferably 1-10 equivalents, of amine are used. Although any solvent including alcohols such as methanol and ethanol, ethers such as THF, ether, DME and dioxane, or aromatic hydrocarbons such as benzene and toluene, can be used as a reaction solvent as long as it is inert under hydrogenation conditions, alcohols are preferably used, with methanol used particularly preferably. Although any acid including inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid, or organic acids such as sulfonic acids including methanesulfonic acid and p-toluenesulfonic acid, benzoic acid, acetic acid or oxalic acid, can be used as long as it forms a salt with an amine, hydrochloric acid, sulfuric acid and methanesulfonic acid are preferably used. Normally, the use of hydrochloric acid in an amount of I equivalent less than the total amount of base yields satisfactory results. These acids can also be added to a reaction system after converting the substrate and reaction agents into salts in advance. Although all catalysts, including platinum catalysts such as platinum oxide and platinum hydroxide, palladium catalysts such as palladium hydroxide and palladium-carbon, and nickel catalysts such as Raney nickel, that are normally used in hydrogenation reactions can be used as a metal catalyst, platinum catalysts, and particularly platinum oxide, are used preferably. The reaction temperature is −30° C. to 80° C., and preferably −10° C. to 50° C., and the hydrogen pressure is 1-100 atmospheres and preferably 1-30 atmospheres. However, carrying out the reaction at room temperature and atmospheric pressure normally yields preferable results.

When reducing with a metal hydride, 1-30 equivalents, and preferably 1-15 equivalents, of amine are used. Although alcohols solvents such as methanol and ethanol, ethers such as THF, ether, DME and dioxane, or aromatic hydrocarbons such as benzene and toluene, can be used for as a solvent, alcohols are used preferably, with methanol used particularly preferably. Although any acid, including inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid, and organic acids such as sulfonic acids including methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, acetic acid and oxalic acid, may be used in the reaction provided that it normally forms a salt with amines, hydrochloric acid, sulfuric acid and methanesulfonic acid are preferably used. In addition, these acids may also be added to the reaction system after converting the substrate and reaction agents into salts in advance. The metal hydride reducing agent used is that which allows the reaction to be carried out relatively stably in the presence of acid, examples of which include sodium borohydride, sodium cyanoborohydride, zinc borohydride, sodium triacetoxyborohydride, tetramethylammonium triacetoxyborohydride and borane-pyridine, with sodium cyanoborohydride used particularly preferably. Although the reaction can be carried out at a reaction temperature of −30° C. to 100° C. and preferably −10° C. to 50° C., satisfactory results can normally be obtained at room temperature.

As shown in Chart 3, a 6β-amino compound represented by the general formula (IIaβ2) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined, and R⁴ represents a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms) can be obtained from a 6-keto compound represented by the general formula (VIIb) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) with the 3 steps described below.

Step 1 involves the obtaining of an iminium intermediate represented by the general formula (X) (wherein R¹, R², R³, R⁴, R⁶, R⁷ and R⁸ are the same as previously defined) by reaction of a keto compound with a secondary amine compound having at least one benzyl substituent group represented by the general formula (IX) (wherein R⁴ is the same as defined above) in the presence of acid. It is desirable that the reaction be carried out while removing water produced either by azeotropic distillation or in the presence of a dehydrating agent. 1-30 equivalents, and preferably 1-10 equivalents, of secondary amine are used. Although any acid, including inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid, or organic acids such as sulfonic acids including methanesulfonic acid and p-toluenesulfonic acid, benzoic acid, acetic acid and oxalic acid, can be used in the reaction as long as it forms a salt with amine, hydrochloric acid, sulfuric acid, methanesulfonic acid and benzoic acid are used preferably, with hydrochloric acid and benzoic acid used particularly preferably. A method wherein these acids are added to the system after converting the substrate and reaction agents into salts in advance is also preferably carried out.

Moreover, in the case of carrying out the reaction in the presence of a weak acid, there are cases wherein preferable results are obtained if a strong acid such as inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid, or sulfonic acids such as methanesulfonic acid, p-toluenesulfonic acid and campher-sulfonic acid especially a strong acid such as p-toluenesulfonic acid is added as an acid catalyst. Examples of reaction solvents that can be used include ethers such as THF, ether, DME and dioxane, halocarbons such as dichloromethane and chloroform, aromatic hydrocarbons such as benzene, toluene and xylene, esters such as ethyl acetate and methyl acetate, or mixtures thereof. When using a conventional Dean-Stark water separator for the purpose of removing water, solvents are used preferably that have excellent azeotropic efficiency and water separation efficiency, such as aromatic hydrocarbons such as benzene and toluene. In this case, the mixing of a solvent such as ethyl acetate, THF or the like, for the purpose of lowering the azeotropic temperature, in amounts that do not lower water separation efficiency may provide preferable results. Although a temperature of 40-200° C., and preferably 50-150° C., can be considered as a reaction temperature, satisfactory results can be obtained at a reaction temperature of 50-130° C. In addition, it has also been found that a new method is effective wherein a dehydrating agent is packed into a Soxhlet type extractor followed by continuous removal of water. Although any of the solvents mentioned above can be used as a solvent in this case, ethers, esters and aromatic hydrocarbons, and particularly THF, DME, ethyl acetate, benzene and toluene, are preferably used. Although examples of dehydrating agents include molecular sieves and inorganic dehydrating agents such as anhydrous calcium sulfate, anhydrous copper sulfate, anhydrous sodium sulfate, anhydrous magnesium sulfate and calcium chloride, molecular sieves are used particularly preferably. The amount used is 1-100 times, and preferably 1-30 times as calculated from their water retentivity and the amount of moisture theoretically produced. Although a temperature of 40-200° C., and preferably 50-150° C., can be considered as a reaction temperature, satisfactory results are obtained at a reaction temperature of 50-120° C. In addition, a method can also be carried out wherein the reaction is allowed to proceed by directly adding dehydrating agent to the reaction system. Examples of dehydrating agents include molecular sieves, inorganic dehydrating agents such as anhydrous calcium sulfate, anhydrous copper sulfate, anhydrous sodium sulfate, anhydrous magnesium sulfate and calcium chloride, or titanium compounds having dehydration ability such as tetraisopropoxytitanium and titanium tetrachloride. In this case also, an amount used is 1-100 times, and preferably 1-30 times as calculated from the water retentivity and the amount of moisture theoretically produced. Although a temperature of −80-100° C. can be considered as a reaction temperature, satisfactory results are obtained at a reaction temperature of −30-50° C.

Step 2 is a step involving conversion to a 6-N-alkyl-N-benzylamino compound represented by the general formula (XI) (wherein R¹, R², R³, R⁴, R⁶, R⁷ and R⁸ are the same as previously defined) by reducing with metal hydride reducing agent without isolating iminium salt. Although the same solvent used in step 1 may be used as is for the reaction solvent of this step, preferable results are obtained by reacting after mixing an alcohols such as methanol or ethanol, and particularly methanol. Naturally, the reaction may also be carried out with only alcohols such as methanol or ethanol after distilling off the reaction solvent of step 1 under reduced pressure. The reaction can be carried out with metal hydride reducing agent that is relatively stable under conditions in the presence of acid, such as sodium borohydride, sodium cyanoborohydride, zinc borohydride, sodium triacetoxyborohydride, tetramethylammonium triacetoxyborohydride and borane-pyridine, particularly preferably sodium cyanoborohydride. The reaction is carried out a reaction temperature of −20-150° C., and preferably 0-120° C. The resulting 6-N-alkyl-N-benzylamino compound represented by the general formula (XI) (wherein R¹, R², R³, R⁴, R⁶, R⁷ and R⁸ are the same as previously defined) can also be obtained using a secondary amine by performing reductive amination using the metal hydride reducing agents of Chart 2. Moreover, if this step is performed using a corresponding secondary amine, the compound of general formula (I) can be obtained wherein A is —NR⁴—.

Step 3 involves removing a benzyl group under reducing conditions to form a 6β-amino form (IIaβ2). In this step, reacting the substrate either after converting into a salt in advance using an inorganic acid such as hydrochloric acid, hydrobromic acid, sulfuric acid or phosphoric acid, or an organic acid such as sulfonic acids including methanesulfonic acid, p-toluenesulfonic acid or campher-sulfonic acid, benzoic acid, acetic acid, oxalic acid or phthalic acid, and preferably hydrochloric acid or phthalic acid, or adding suitable amount of these acids prior to the reaction, yields favorable results. Since there are cases in which a resulting secondary amine salt can be purified as a crystal depending on the acid, selection of acid is important. For example, when phthalic acid is used with a compound wherein R¹ is a cyclopropylmethyl group, R² and R³ are hydroxy groups, R⁴ is a methyl group, R⁶ and R⁷ are together —O— and R⁸ is a hydrogen atom, a crystalline salt is obtained that is easily purified. Although any solvent such as alcohol-based solvents such as methanol and ethanol, ethers such as THF, ether, DME and dioxane, and organic hydrocarbons such as benzene and toluene, can be used as a reaction solvent provided it is inert under hydrogenation conditions, alcohols are used preferably, with methanol used particularly preferably. Although any catalyst that is used in normal hydrogenation reactions, such as, platinum catalysts such as platinum oxide and platinum hydroxide, palladium catalysts such as palladium hydroxide and palladium-carbon, and nickel catalysts such as Raney nickel, can be used as a metal catalyst, palladium catalysts, and particularly palladium-carbon, are particularly preferably used. The reaction temperature is −30 to 80° C., and preferably −10 to 50° C. while hydrogen pressure is 1 to 100 atmospheres, and preferably 1 to 30 atmospheres. However, carrying out the reaction at room temperature and atmospheric pressure normally yields favorable results.

In addition, when ammonium acetate is used in place of primary amine in the reductive amination reaction shown in Chart 2, when dibenzylamine is used in the method shown in Chart 3, or after converting ketone into oxime using the method described in the literature (J. Med. Chem., 27, 1727 (1984)), a primary amine can be obtained by reducing with borane or under hydrogenation conditions. This primary amine can be converted into a secondary amine by effecting the acylation and reduction of step 2. This is also useful as an alternative route for obtaining the secondary amine.

As shown in Chart 4, a 6-α-alcohol represented by the general formula (IIba) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) is obtained either by reducing with metal hydride reducing agent or hydrogenation in the presence of acid and metal catalyst. Although metal hydride reducing agents including sodium borohydride, sodium cyanoborohydride, zinc borohydride, sodium triacetoxyborohydride, L-selectride and lithium aluminum hydride can be used, sufficiently satisfactory results are obtained with sodium borohydride. Although solvents including alcohols such as methanol and ethanol, and ethers such as THF, ether, DME and dioxane are used, alcohols, and particularly methanol, are preferably used. In the case of hydrogenation, examples of solvents that are used include alcohols such as methanol and ethanol, and ethers such as THF, ether and dioxane, with alcohols being used preferably, and methanol being used particularly preferably.

Although acids such as inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid or phosphoric acid, and organic acids such as sulfonic acids including methanesulfonic acid and p-toluenesulfonic acid, benzoic acid are used, acetic acid or oxalic acid, hydrochloric acid is preferably used. Although all catalysts that are used in normal hydrogenation reactions such as platinum catalysts such as platinum oxide or platinum hydroxide, palladium catalysts such as palladium hydroxide or palladium-carbon, and nickel catalysts such as Raney nickel can be used as a metal catalyst, platinum catalysts, and particularly platinum oxide are preferably used. Although the reaction can be carried out at a reaction temperature of −30-80° C., and preferably −10-50° C., and under a hydrogen pressure of 1-100 atmospheres, and preferably 1-30 atmospheres, favorable results are normally obtained at room temperature and under atmospheric pressure.

As shown in Chart 5, a 6β-hydroxy form represented by the general formula (IIbβ) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) can be obtained by reacting a 6-keto form represented by the general formula (VIIa) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) with formamidine sulfinic acid in the presence of a base. Preferable examples of a base used include inorganic bases such as sodium hydroxide, potassium hydroxide, potassium carbonate and sodium bicarbonate, with sodium hydroxide being used particularly preferably. Although examples of reaction solvents used include water, alcohols such as methanol and ethanol, and aprotic, dipolar solvents such as DMF and DMSO, the use of water normally yields satisfactory results. Although a temperature of 0-150° C. is considered as a reaction temperature, a temperature of 60-100° C. is preferable.

Among the 6-amino or 6-hydroxy compound synthesized in the above method, particularly a compound wherein R³ is a hydrogen atom, is obtained by methods similar to those shown in Charts 2, 3, 4 and 5, using as a starting material a 3-dehydroxy-6-keto compound represented by the general formula (VIIe) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group), obtained by using as a substrate a 3-hydroxy-6-keto compound represented by the general formula (VIIc) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group) according to the scheme shown in Chart 6. In addition, an intermediate, wherein R³ is a siloxy group, can be obtained by methods similar to those shown in Charts 2, 3, 4 and 5, by using for as a starting material a 3-siloxy-6-keto form represented by the general formula (VIIf) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group and G represents an alkylsilyl group), obtained from a 3-hydroxy-6-keto compound (VIIc) by the scheme shown in Chart 7.

Namely, as shown in Chart 6, the first step for obtaining a 3-dehydroxy-6-keto compound represented by the general formula (VIIe) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group) is a step wherein trifluoromethane sulfonic anhydride is caused to act on a phenolic hydroxyl group in the presence of a base to form a trifrate form represented by the general formula (VIId) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group). Although solvents such as halocarbons such as dichloromethane and chloroform, ethers such as THF, ether, DME and dioxane, and amines having large steric hindrances that can be used as solvents such as 2,6-lutidine and diisopropylethylamine, can be considered for use as a reaction solvent, halocarbons, and particularly dichloromethane, are preferably used.

Although tertiary amines such as triethylamine, diisopropylethyl amine and proton sponge, as well as pyridine, 2,6-lutidine and imidazole are used as a coexisting base, 2,6-lutidine is preferably used. Although the reaction can be carried out at −30-50° C., satisfactory results can be normally attained at a temperature of 0° C. to room temperature normally yields. Step 2 is a step wherein a trifrate form is reduced with formic acid in the presence of phosphorous ligand and a base using a palladium catalyst. Although amines usable as solvents such as triethylamine and diisopropylethylamine, ethers such as THF, ether, DME and dioxane, aromatic hydrocarbons such as benzene and toluene, and aprotic dipolar solvents such as DMF and DMSO are used for the reaction solvent, DMF is particularly preferably used. Although zero-valent complexes such as tetrakuistriphenylphosphine palladium and bisbenzylideneacetone palladium, and bivalent complexes such as palladium acetate and palladium chloride are frequently used for the palladium catalyst, palladium acetate is used normally.

Although monodentate phosphines such as trimethylphosphine, triethylphosphine, triphenylphosphine and tris-o-toluphosphine, and bidentate phosphines such as bis-(diphenylphosphino)methane, 1,2-bis-(diphenylphosphino) ethane, 1,3-bis-(diphenylphosphino)propane and 1,1′-bis-diphenylphosphinoferrocene, are used as a phosphorous ligand, 1,1′-bis-diphenylphosphinoferrocene is particularly preferably used. Although amines such as triethylamine and diisopropylethylamine, and inorganic salts such as silver carbonate, sodium acetate and potassium acetate, are used as a base used in the reaction, triethylamine is preferably used. The reaction is carried out at a reaction temperature of 0-150° C., and satisfactory results are normally obtained at a room temperature to 80° C.

As shown in Chart 7, a 3-hydroxy-6-keto form represented by the general formula (VIIc) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined) may be reacted with silylchloride in the presence of a base to obtain a 3-siloxy-6-keto form represented by the general formula (VIIf) (wherein R¹, R², R⁶, R⁷ and R⁸ are the same as previously defined, provided that R⁷ is not a hydroxy group and G represents an allcylsilyl group). Although trimethylsilylchloride, triphenylsilylchloride, t-butyldimethylsilylchloride and diphenylmethylsilylchloride are mentioned as silylchlorides, t-butyldimethylsilylchloride is preferably used. Although tertiary amines such as triethylamine, diisopropylethylamine and proton sponges, as well as pyridine, dimethylaminopyridine and imidazole are used as a base, imidazole is preferably used. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers, such as ether, THF, DME and dioxane, and pyridine are used as a solvent, dichloromethane is preferably used. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained particularly in the vicinity of 0° C. to room temperature. Although the reaction can be carried out in 5-300 minutes, since there are cases in which 6th position ketone groups are also enolsilylated when reaction time is lengthened particularly with respect to compounds wherein

is a single bond and R6 and R7 together are —O—, a reaction time of 5-60 minutes is preferable.

As shown in Chart 8, compounds wherein X is NR⁴ can be obtained by condensing a 6-amino form represented by the general formula (Ila) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined, and R⁴ represents a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms), obtained by the methods shown in Charts 2 and 3, with a carboxylic acid and carboxylic acid derivative represented by the general formula (III) (wherein B and R⁵ are the same as previously defined), or with a formic acid derivative represented by the general formula (IV) (wherein Z, B and R⁵ are the same as previously defined), or with a isocyanic acid or isothiocyanic acid derivative represented by the general formula (V) (wherein B and R⁵ are the same as previously defined), or with a sulfonic acid derivative represented by the general formula (VI) (wherein B and R⁵ are the same as previously defined), etc.

Condensation with a carboxylic acid derivative can be performed by reacting a 6-amino form with an acid chloride or acid anhydride that reacts in the presence of a base, or by reacting with carboxylic acid itself using, for example, N,N′-dicyclohexylcarbodiimide (abbreviated as DCC), 1,1′-carbonyldiimidazole, or bis-(2-oxo-3-oxazolidinyl)phosphinate chloride (abbreviated as BOPC), etc. Acid chloride or acid anhydride is used in an amount of 1-20 equivalents, and preferably 1-5 equivalents. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers such as ether, THF, DME and dioxane, pyridine, water or a mixture of these are used as reaction solvents, when using acid chloride, chloroform or a mixed solvent of THF and water is used preferably. In the case of using acid anhydride, pyridine is preferably used both as base and solvent. Although organic bases such as tertiary amines including triethylamine, diisopropylethylamine and proton sponges, pyridine, dimethylaminopyridine and imidazole, and inorganic bases such as potassium carbonate, sodium carbonate, sodium bicarbonate, sodium hydroxide and potassium hydroxide are used as bases, when using chloroform as the solvent, trimethylamine is normally used in an amount of 1-20 equivalents, and preferably 1-5 equivalents. In the case of using a mixed solvent of THF and water, the use of potassium carbonate, sodium carbonate or sodium bicarbonate in an amount of 1-20 equivalents, and preferably 1-5 equivalents, provides satisfactory results. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained particularly at a temperature of from 0° C. to room temperature. In the case of using DCC as a condensing agent, an amount of 1-20 equivalents preferably 1-5 equivalents is used. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, and ethers such as ether, THF, DME and dioxane are used as reaction solvents, dichloromethane and chloroform are particularly preferably used. Although organic bases such as tertiary amines including triethylamine, diisopropylethylamine and proton sponges, as well as pyridine, dimethylaminopyridine and imidazole are used as coexisting bases, dimethylaminopyridine in an amount of 0.01-2 equivalents is used particularly preferably. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained in the vicinity of 0° C. to room temperature in particular.

In the case of using 1,1′-carbonyldiimidazole as a condensing agent, an amount of 1-20 equivalents, and preferably 1-5 equivalents is used. Although ethers such as ether, THF, DME and dioxane, and halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane are used as reaction solvents, THF is particularly preferably used. The reaction can be carried out within a range of −20-120° C., and a temperature in the vicinity of room temperature to 100° C. is particularly preferable. In the case of using BOPCL as a condensing agent, it is used in an amount of 1-20 equivalents, and preferably 1-5 equivalents. Examples of solvents used for the reaction (solvent) include halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, and ethers such as ether, THF, DME and dioxane, though dichloromethane and chloroform are particularly preferably used. Although organic bases such as tertiary amines including triethylamine, diisopropylethylamine, proton sponge and N-ethylpiperidine, as well as pyridine, dimethylaminopyridine and imidazole are used as coexisting bases, N-ethylpiperidine in an amount of 1-20 equivalents, and preferably 1-5 equivalents, is particularly preferably used. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained at 0-50° C. in particular.

Condensation with a formic acid derivative can be performed by reacting a 6-amino form with 1-20 equivalents and preferably 1-5 equivalents of an acid chloride that reacts in the presence of base. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers such as ether, THF, DME and dioxane, water or mixtures of these solvents are used as reaction solvents, chloroform and a mixed solvent of THF and water are particularly preferably used. Although organic bases such as tertiary amines including triethylamine, diisopropylethylamine and proton sponge, pyridine, dimethylaminopyridine and imidazole, and inorganic bases such as potassium carbonate, sodium carbonate and sodium bicarbonate are used as bases, triethylamine in an amount of 1-20 equivalents, and preferably 1-5 equivalents provides satisfactory results when chloroform is used as a solvent, while potassium carbonate, sodium carbonate and sodium bicarbonate used in an amount of 1-20 equivalents, and preferably 1-5 equivalents, normally provides favorable results when a mixed solvent of THF and water is used as a solvent. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained from 0° C. to the vicinity of room temperature.

Condensation with an isocyanic acid or isothiocyanic acid derivative can be performed by reacting 1-20 equivalents, and preferably 1-5 equivalents, of a corresponding isocyanate ester with a 6-amino form. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, and ethers such as ether, THF, DME and dioxane are used as reaction solvents, chloroform is particularly preferably used. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained from 0° C. to the vicinity of room temperature.

Condensation with a sulfonic acid derivative can be performed by reacting 1-20 equivalents, and preferably 1-5 equivalents, of the corresponding sulfonate chloride with a 6-amino form in the presence of base. Examples of bases that are used include tertiary amines such as triethylamine, diisopropylethylamine and proton sponges, as well as pyridine, dimethylaminopyridine and imidazole. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers such as ether, THF, DME and dioxane, and pyridine are used as bases, pyridine is particularly preferably used as both base and solvent. The reaction can be carried out within a range of −80-100° C., and preferable results are obtained from 0° C. to the vicinity of room temperature in particular.

In the case of compounds wherein R³ is a hydroxy group in particular, since there are cases in which phenolic hydroxyl groups may react simultaneously, after carrying out step 1 in the same manner as shown in Chart 8, as shown in Charts 9-11 with carboxylic acid derivative, formic acid derivative and isocyanic acid or isothiocyanic acid derivative, the target compound can be obtained by performing alkaline treatment for step 2. Examples of solvents used for a reaction solvent of step 2 include water, alcohols such as methanol and ethanol, ethers such as ether, THF, DME and dioxane, or mixed solvents of those solvents. When solubility is inadequate, halocarbons such as dichloromethane and chloroform can be suitably added. Examples of bases used include inorganic bases such as potassium carbonate, sodium carbonate, sodium bicarbonate, sodium hydroxide and potassium hydroxide. Normally, 1-20 equivalents, and preferably 1-10 equivalents, of potassium carbonate, sodium hydroxide and so forth are used preferably. The reaction can be carried out within a range of −80-100° C., and favorable results are obtained from 0-50° C. in particular.

When condensing compounds wherein R³ is a hydroxy group with sulfonic acid derivative, as shown in Chart 12, preferable results are obtained by using a 3-siloxy-6-amino form, wherein phenolic hydroxyl groups are protected in advance with silylether groups and so forth, represented by the general formula (IIc) (wherein R1, R2, R4, R6, R7, R8 and G are the same as previously defined). Naturally, the following method can also be applied to condensation with a carboxylic acid derivative, formic acid derivative and isocyanic acid or isothiocyanic acid derivative. Namely, this method involves removing silyl groups after carrying out step 1 in the same manner as shown in Chart 8. Although quaternary ammonium salts such as tetrabutylammonium fluoride, tetrabutylammonium chloride and pyridinium hydrofluoride, or acids such as acetic acid, hydrochloric acid, sulfuric acid and hydrofluoric acid, are used for removal of silyl groups in step 2, normally 1-20 equivalents, and preferably 1-5 equivalents, of tetrabutylammonium fluoride are used. Although ethers such as THF, ether, DME and dioxane, halocarbons such as dichloromethane and chloroform, and acetonitrile are used as solvents, THF is particularly preferably used. Although the reaction can be carried out at −20-100° C., satisfactory results can normally be obtained at room temperature.

In addition, a 6-amino form represented by the general formula (Im) (wherein R¹, R², R³, R⁴, B, R⁵, R⁶, R⁷ and R⁸ are the same as previously defined), in which A is —NR⁴—, is obtained by reducing an amide form represented by the general formula (Ie′) (wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸ and B are the same as previously defined) using a metal hydride reducing agent. Examples of reducing agents used include metal hydride compounds having a strong reducing activity such as lithium aluminum hydride, aluminum diisobutylaluminumhydride, aluminum hydride, lithium borohydride and diborane, 1-20 equivalents, and preferably 1-5 equivalents of diborane are particularly preferably used. Ethers such as THF, DME, ether and dioxane are used preferably as a solvent when using lithium aluminum hydride, lithium borohydride or diborane, with THF being used particularly preferably. Aromatic hydrocarbons such as benzene and toluene are used preferably as a solvent when diisobutylaluminumhydride or aluminum hydride are used. The reaction can be carried out within a range of −40 to 100° C., and a temperature from 0° C. to the vicinity of room temperature is preferable.

As shown in Chart 14, compounds wherein X is O can be obtained by condensing a 6-hydroxy form represented by the general formula (IIb) (wherein R¹, R², R³, R⁶, R⁷ and R⁸ are the same as previously defined) obtained in Charts 4 and 5, with a carboxylic acid derivative (III), a formic acid derivative (IV), an isocyanic acid, an isothiocyanic acid derivative (V), or sulfonic acid derivative (VI) and so forth.

Condensation with a carboxylic acid derivative can be performed by treatment of a 6-hydroxy compound with 1-20 equivalents, and preferably 1-5 equivalents of an acid chloride or acid anhydride in the presence of base. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers such as ether, THF, DME and dioxane, and pyridine are used as a reaction solvents, chloroform is used preferably wnen using acid chloride, while pyridine is used preferably in the case of using acid anhydride. Although tertiary amines such as triethylamine, diisopropylethylamine and proton sponge, as well as pyridine, dimethylaminopyridine and imidazole are used as bases, the use of both diisopropylethylamine and dimethylaminopyridine in an amount of 1-20 equivalents, and preferably 1-5 equivalents, normally provides satisfactory results. The reaction can be carried out at −80 to 100° C., and preferable results are obtained at a temperature of from the vicinity of room temperature to 80° C. in particular.

Condensation with a formic acid derivative can be performed by reacting a 6-hydroxy form with 1-20 equivalents, and preferably 1-5 equivalents, of an acid chloride that reacts in the presence of a base. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, and ethers such as ether, THF, DME and dioxane are used as reaction solvents, chloroform and carbon tetrachloride are used particularly preferably. Although tertiary amines such as triethylamine, diisopropylethylamine and proton sponges, as well as pyridine, dimethylaminopyridine and imidazole are used as bases, the use of both diisopropylethylamine and dimethylaminopyridine in an amount of 1-20 equivalents, and preferably 1-5 equivalents, normally provides satisfactory results. The reaction can be carried out within a range of −80 to 100° C., and preferable results are obtained from the vicinity of room temperature to 80° C. in particular.

Condensation with an isocyanic acid or isothiocyanic acid derivative can be performed by reacting 1-20 equivalents, and preferably 1-5 equivalents, of the corresponding isocyanate ester with a 6-hydroxy form. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, and ethers such as ether, THF, DME and dioxane are used as reaction solvent, chloroform is used particularly preferably. The reaction can be carried out within a range of −80 to 100° C., and preferable results are obtained at a temperature of from the vicinity of room temperature to 80° C. in particular.

Condensation with a sulfonic acid derivative can be carried out by treatment of 1-20 equivalents, and preferably 1-5 equivalents, of a corresponding sulfonic chloride with a 6-hydroxy form in the presence of a base. Examples of a base used include tertiary amines such as triethylamine, diisopropylethylamine and proton sponges, as well as pyridine, dimethylaminopyridine and imidazole. Although halocarbons such as dichloromethane, chloroform, carbon tetrachloride and 1,2-dichloroethane, ethers such as THF, DME and dioxane, and pyridine are used as reaction solvent, pyridine is used particularly preferably, both as base and solvent. The reaction can be carried out within a range of −80 to 100° C., and preferable results are obtained at a temperature of the vicinity of room temperature to 80° C. in particular.

In the case of compounds wherein R³ is a hydroxy group in particular, since phenolic hydroxyl group also reacts simultaneously, in the case of carboxylic acid derivative, formic acid derivative, and isocyanic acid or isothiocyanic acid derivative, after performing a condensation reaction in the same manner as shown in Chart 14 as step 1, the target compound can be obtained by performing alkaline treatment for step 2 as shown in Charts 15-17. Examples of solvents used as reaction solvent of step 2 include alcohols such as methanol and ethanol, and when solubility is not adequate, halocarbons such as dichloromethane, and chloroform can ben suitably added. Examples of a base used include inorganic bases such as potassium carbonate, sodium carbonate, sodium bicarbonate, sodium hydroxide and potassium hydroxide, with potassium carbonate normally being used preferably. The reaction can be carried out within a range of −80 to 100° C., and preferable results are obtained at −20 to 50° C. in particular. However, since solvolysis of functional group at the 6 position may also proceed, in such cases, this problem is solved by either lowering the reaction temperature or shortening the reaction time.

The use of a 3-siloxy-6-hydroxy form represented by the general formula (IId) (wherein R¹, R², R⁶, R⁷, R⁸ and G are the same as previously defined), in which phenolic hydroxyl groups are protected in advance with silylether group and so forth, for condensation with a sulfonic acid derivative yields preferable results. Naturally, this method can be carried out for condensation with a carboxylic acid derivative, a formic acid derivative, an isocyanic acid or an isothiocyanic acid derivative. After performing condensation in the same manner as shown in Chart 14 as step 1, silyl group is removed in step 2. Although quaternary ammonium salts such as tetrabutylammonium fluoride, tetrabutylammonium chloride and pyridinium hydrofluoride, or acids such as acetic acid, hydrochloric acid, sulfuric acid and hydrofluoric acid, may be used for removal of silyl groups, normally 1-20 equivalents, and preferably 1-5 equivalents, of tetrabutylammonium fluoride are used. Examples of solvents used include ethers such as THF, DME and dioxane, acetonitrile and halocarbons such as dichloromethane and chloroform, though THF is used particularly preferably. Although the reaction can be carried out at −20-100° C., satisfactory results are normally obtained at room temperature.

The free base obtained in the above steps can be converted into the salts with pharmacologically acceptable acids specifically by the methods shown below. Namely, a resulting free base is dissolved or suspended in a solvent followed by addition of acid and filtering of the precipitated solid or crystal, or in the case of not precipitating, a solvent of lower polarity is added, or the solvent is substituted with a solvent of lower polarity and filtering after precipitation. Alternatively, concentration and drying are performed after forming a salt. However, in the case organic solvent remains in these methods, drying under reduced pressure may be performed after freeze-drying in an aqueous solution. Examples of solvents used to dissolve or suspend the above free base include water, alcohols such as methanol, ethanol and isopropyl alcohol, halocarbons such as dichloromethane and chloroform, ethers such as ether, THF, DME and dioxane, esters such as ethyl acetate and methyl acetate, or their mixed solvents, while preferable examples include methanol, ethanol, isopropyl alcohol, ethyl acetate, chloroform, chloroform-methanol, water-methanol, and water-ethanol. Preferable examples of solvents used for precipitating solid include ether and ethyl acetate. Although it is desirable that an equivalent amount of acid be added, when it is possible to remove excess acid after washing the resulting salt, 1-10 equivalents may be used. In addition, acid may be added as is or suitably dissolved in the above-mentioned solvents and then added. For example, hydrochloric acid can be added in the form of concentrated hydrochloric acid, 1 N aqueous solution, a saturated methanol solution or a saturated ethyl acetate solution, while tartaric acid can be added in the form of a solid, an aqueous solution or a methanol solution. At the time of salt formation, since the temperature of the system may rise due to the heat of neutralization, there are cases in which favorable results are obtained if a water bath or ice bath is used.

As a result of in vitro and in vivo pharmacological testing, the compounds of the present invention represented by the general formula (I) are known to have strong analgesic and diuretic activity as an opioid κ-agonist, and it became clear that it can be expected to be used as a useful analgesic and diuretic. In addition, based on the properties of κ-agonists, it is also possible to use this compound as a hypotensive and sedative. Moreover, it was also found that the compounds of the present invention also include agonists highly selective for δ-receptors, thus suggesting the possibility of their use as an immunoenhancer, anti-HIV agent and so forth.

At the time of clinical use of the analgesic or diuretic of the present invention, it may be used as in the form of a free base or its salt, or suitably mixed with vehicles such as stabilizer, buffer, diluent, isotonic agents and preservatives. Examples of administration forms include injection preparations; oral preparations such as capsules, powders, granules and syrup, transintestinal administration in the form of suppositories; or topical administration in the form of ointments, creams and plasters. It is desirable that the analgesic of the present invention contain 1-90% by weight, and preferably 30-70% by weight of the above-mentioned active ingredient. Although the amount used is suitably selected according to symptoms, age, body weight and administration method, the adult dose as the amount of active ingredient in the case of an injection preparation is 0.0001 mg-1 g per day, and 0.005 mg-10 g per day in the case of an oral preparation. In both cases, administration may be performed in a single dose or divided among several administrations.

EXAMPLES

Although the following provides an explanation of the present invention in the form of the specific examples described below, the present invention is not limited to these examples.

Reference Example 1

N-Acetylbenzylamine

10 g of benzylamine was dissolved in 200 ml of methylene chloride followed by the addition of 26 ml of triethylamine and dropwise addition of 7.3 ml of acetyl chloride at 0° C. After stirring for 1 hour at room temperature, 2 ml of methanol was added to the reaction system at 0° C. followed by 120 ml of water and separation of the phases. The aqueous layer was extracted with 100 ml of chloroform, and the resulting organic layer was concentrated after drying with anhydrous sodium sulfate to obtain 8.55 g of the target compound (yield: 61%).

NMR (90 MHz, CDCl₃)

δ 1.9 (3H, s), 4.3 (2H, d, J=4.8 Hz), 6.8 (1H, br s), 7.3 (5H, s).

IR (liquid film method)

υ 3296, 1649, 1543, 1499, 1377, 1359, 1284, 1077, 1033 cm⁻¹

Reference Example 2

N-Benzylethylamine

2.96 g of the N-acetylbenzylamine obtained in reference example 1 was dissolved in 45 ml of anhydrous tetrahydrofuran followed by the addition of 1.73 g of lithium aluminum hydride at 0° C. After stirring for 2 hours at room temperature, the reaction mixture was refluxed while heating for 2 hours. After cooling the reaction mixture to 0° C., 22.8 g of sodium fluoride was added followed by dropwise addition of 91 ml of 10% aqueous tetrahydrofuran and stirred for 1 hour at room temperature. The precipitate was removed using Celite and the filtrate was concentrated to obtain 2.5 g of the target compound in liquid form (yield: 93%).

NMR (90 MHz, CDCl₃)

δ 1.10 (3H, t, J=7.3 Hz), 1.4 (1H, brs), 2.65 (2H, q, J=7.3 Hz), 3.75 (2H, s), 7.15-7.4 (5H, m).

Reference Example 3

3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6-oxomorphinan 2

3.49 g of naltrexone hydrochloride was suspended in 10.5 ml of N,N-dimethylformamide. After adding 3.46 g of imidazole, 3.48 g of tert-butyldimethylchlorosilane was added followed by stirring for 35 minutes at room temperature. 30 ml of water and 50 ml of diethyl ether were added to the reaction system followed by separation. The aqueous layer was extracted twice with 30 ml of diethyl ether. The combined extracts were dried over anhydrous sodium sulfate and concentrated. The resulting residue was recrystallized from ethanol to obtain 3.2 g of the target compound (yield: 76%).

NMR (90 MHz, CDCl₃)

δ 0.0-1.2 (5H, m), 0.2 (3H, s), 0.3 (3H, s), 1.0 (9H, s), 1.3-2.0 (3H, m), 2.0-3.2 (8H, m), 2.4 (2H, d, J=4.4 Hz), 4.60 (1H, s), 6.5 (1H, d, J=6.4 Hz), 6.6 (1H, d, J=6.4 Hz).

Reference Example 4

3-Dehydroxynaltrexone 3

Naltrexone (5 g) was dissolved in dichloromethane (50 ml) followed by the addition of 2,6-lutidine (2.56 ml) and anhydrous trifluoromethanesulfonic acid (2.96 ml) at 0° C. After reacting for 15 minutes at the same temperature, distilled water (40 ml) and saturated aqueous sodium bicarbonate (20 ml) were added followed by extraction with chloroform (20+30 ml). After washing with saturated brine, the extracts was dried with anhydrous sodium sulfate and the solvent was distilled off. Ether (20 ml) was added and the precipitating solid was filtered out using Celite followed by initial purification with silica gel column chromatography (Merk 7734, 300 g; chloroform→1% methanol/chloroform).

The initially purified product was dissolved in anhydrous DMF (25 ml) and reacted with triethylamine (5.9 ml), palladium acetate (0.06 g), DPPF (0.16 g) and formic acid (1.1 ml) for 15 minutes at 60° C. After distilling off the solvent, saturated aqueous sodium bicarbonate (20 ml) and distilled water (10 ml) were added followed by extraction with chloroform (30 ml×2). After washing with saturated brine and drying with anhydrous sodium sulfate, the solvent was distilled off and the resulting black oily substance was purified with silica gel column chromatography (Merk 7734, 300 g; chloroform) to obtain the target compound (3.32 g, yield: 62%).

NMR (400 MHz, CDCl₃)

δ 0.26 (2H, m), 0.57 (2H, m), 0.88 (1H, m), 1.54 (1H, dd, J=12.7, 2.0 Hz), 1.63 (1H, dt, J=14.7, 3.9 Hz), 1.89 (1H, m), 2.13 (1H, dt, J=12.7, 3.9 Hz), 2.31 (1H, dt, J=14.7, 2.9 Hz), 2.42 (3H, m), 2.63 (1H, dd, J=18.6, 5.7 Hz), 2.70 (1H, dd, J=12.7, 4.9 Hz), 3.04 (1H, dt, J=14.7, 4.9 Hz), 3.11 (1H, d, J=19.5 Hz), 3.21 (1H, d, J=5.9 Hz), 4.65 (1H, s), 5.0-5.5 (1H, br), 6.69 (1H, d, J=6.8 Hz), 6.75 (1H, d, J=6.8 Hz), 7.07 (1H, t, J=6.8 Hz)

IR (neat)

υ 3406, 1729, 1630, 1607, 1458, 1052, 938, 781 cm⁻¹

Mass (EI)

m/z 325 (M+)

Example 1

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4

Naltrexone (1.0 g) and methylamine hydrochloride (0.99 g, 5 equivalents) were dissolved in methanol (15 ml) followed by stirring for 20 minutes at room temperature. This reaction solution was added to platinum oxide (0.05 g, 5 w %) in methanol (10 ml) activated in advance in a hydrogen atmosphere followed by hydrogenation for 4 hours at room temperature and atmospheric pressure. The catalyst was removed by Celite filtration and the solvent was distilled off. After adding saturated aqueous sodium bicarbonate (20 ml) and extracting with chloroform (20 ml×2), the extract was washed with saturated brine and dried with anhydrous sodium sulfate, and the solvent was distilled off. The resulting dark reddish-violet oily substance was dissolved in chloroform (2 ml) followed by addition of ethyl acetate (4 ml) to obtain the target compound (0.83 g, yield: 79%) by crystallization. A portion of this compound was removed and various spectra were measured in the form of a hydrochloride.

mp 270° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.48 (1H, m), 0.61 (1H, m), 0.69 (1H, m), 0.95 (1H, m), 1.08 (1H, m), 1.47 (1H, m), 1.70 (1H, d, J=13.2 Hz), 1.81 (1H, m), 1.92 (1H, m), 2.49 (1H, m), 2.68 (3H, s), 2.72 (1H, m), 3.00 (1H, m), 3.08 (2H, m), 3.26 (2H, m), 3.57 (1H, m), 4.01 (3H, m), 4.97 (1H, brs), 6.50 (1H, s), 6.65 (1H, d, J=8.3 Hz), 6.78 (1H, d, J=8.3 Hz), 9.20 (2H, m)

1R (KBr)

υ 3200, 1510, 1464, 1238, 1116, 982, 859 cm⁻¹

Mass (EI)

m/z 356 (M+) (measured in the free form)

Elementary Analysis: AS C₂₁H H₂₈N₂O₃.2HCl.0.2H₂O

Calculated values: C 58.25; H 7.08; N 6.47; Cl 16.38

Measured values: C 58.35; H 7.20; N 6.44; Cl 16.14

Example 2

17-Cyclopropylmethyl-4,5α-epoxy-3, 14β-dihydroxy-6α-isobutylaminomorphinan a was obtained by following the procedure of example 1 but using isobutylaline instead of methylamine.

NMR (500 MHz, CDCl₃)

δ 0.22 (2H, m), 0.53 (2H, m,0.84 (1H, m,0.92 (1H, m), 0.94 (3H, d, J=6.7 Hz), 0.95 (3H, d, J=6.1 Hz), 1.40 (1H, dd, J=14.7, 10.4 Hz), 1.57 (1H, m), 1.68 (2H, m), 1.83 (1H, m), 2.30 (4H, m), 2.55 (2H, m), 2.63 (2H, m), 3.00 (1H, d, J=18.3 Hz), 3.06 (1H, d, J=6.7 Hz), 3.18 (1H, dt, J=13.4, 3.7 Hz), 4.3-5.2 (3H, br), 4.66 (1H, d, J=3.7 Hz), 6.46 (1H, d, J=7.9 Hz), 6.64 (1H, d, J=7.9 Hz)

IR (neat)

υ 3350, 1609, 1460, 1249, 1118, 913 cm⁻¹

Mass (EI)

m/z 398 (M+)

Example 3

17-Cyclopropylmethyl-14β-hydroxy-4,5α-epoxy-6α-methylaminomorphinan 6 (yield: 75%) was obtained by following the procedure of example 1 but using 3-dehydroxynaltrexone 3 instead of naltrexone hydrochloride.

NMR (500 MHz, CDCl₃)

δ 0.13 (2H, m), 0.54 (2H, m), 0.75 (1H, m), 0.86 (1H, m), 1.40 (1H, dd, J=14.7, 5.5 Hz), 1.57 (1H, m), 1.63 (1H, m), 1.72 (2H, m), 2.25 (2H, m), 2.36 (2H, m), 2.52 (3H, s), 2.65 (2H, m), 3.08 (3H, m), 4.70 (1H, dd, J=3.7, 1.8 Hz), 4.9-5.1 (1H, br), 6.56 (1H, d, J=7.9 Hz), 6.61 (1H, d, J=7.3 Hz), 7.04 (1H, t, J=7.9 Hz)

IR (neat)

υ 3372, 1605, 1560, 1543, 1458, 1104, 864 cm⁻¹

Mass (EI)

m/z 340 (M+)

Example 3

3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-methylaminomorphinan 7 (yield: 50%) was obtained by following the procedure of example 1 but using 3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6-oxomorphinan 2 instead of Naltrexone hydrochloride.

NMR (90 MHz, CDCl₃)

δ 0.0-1.2 (5H, m), 0.19 (3H, s), 0.2 (3H, s), 1.0 (9H, s), 1.3-1.9 (4H, m), 2.2-2.8 (7H, m), 2.56 (3H, s), 3.0 (1H, d, J=7.6 Hz), 3.0-3.3 (2H, m), 4.75 (1H, d, J=3.6 Hz), 6.5 (1H, d, J=7.2 Hz), 6.63 (1H, d, J=7.2 Hz)

Example 4

6β-(N-Benzyl)methylamino-17-cyclopropylmethyl-4,5α-epoxy-3, 14β-dihydroxymorphinan 8

10.1 g of Naltrexone hydrochloride was separated with 150 ml of a 4:1 solution of chloroform and methanol and 150 ml of saturated aqueous sodium bicarbonate. The aqueous layer was extracted twice with 100 ml of a 4:1 solution of chloroform and methanol. The resulting organic layer was dried with anhydrous sodium sulfate followed by the addition of 3.26 g of benzoic acid and concentration after completely dissolving. After adequately drying the residue with a vacuum pump, the residue was suspended in 400 ml of benzene. After adding 5.2 ml of benzylmethylamine, 4.9 g of benzoic acid and 0.23 g of p-toluenesulfonic acid, the resulting mixture was stirred for 18 hours in a 110° C. oil bath while boiling off the water. After distilling off 330 ml of benzene at atmospheric pressure, 330 ml of ethanol and 4 g of molecular sieves 4A were added to the reaction mixture followed by cooling to 0° C. Next, 2.52 g of sodium cyanoborohydride was added followed by stirring for 2 hours at room temperature. After adding 200 ml of methanol to the reaction system, the molecular sieves was filtered out and the filtrate was concentrated. 200 ml of chloroform and 150 ml of saturated aqueous sodium bicarbonate were added to the resulting residue and the resulting precipitate was filtered followed by separation. The aqueous layer was extracted twice with 100 ml of chloroform, and the organic layer was concentrated after drying with anhydrous sodium sulfate. The resulting crude product was purified with silica gel column chromatography (480 g ammonia saturated ammonium chloroform/chloroform=2/1) to obtain 10.87 g of the oily target compound (yield: 91%). This was then recrystallized from methanol.

mp 71-80° C. (decomposition)

NMR (400 MHz, CDCl₃)

δ (0.09-0.13 (2H, m), 0.49-0.55 (2H, m), 0.79-0.88 (1H, m), 1.25-1.35 (1H, m), 1.43-1.49 (1H, m), 1.59-1.66 (2H, m), 1.87-2.00 (1H, m), 2.11 (1H, dt, J=3.4, 11.7 Hz), 2.19-2.27 (1H, m), 2.34 (3H, s), 2.35 (2H, d, J=6.8 Hz), 2.50-2.59 (1H, m), 2.56 (1H, dd, J=5.4, 18.1 Hz), 2.62 (1H, dd, J=4.4, 11.7 Hz), 2.99 (1H, d, J=18.l Hz), 3.04 (1H, d, J=5.4 Hz), 3.53 (1H, d, J=13.2 Hz), 3.82 (1H, d, J=13.7 Hz), 4.68 (1H, d, J=8.3 Hz), 6.51 (1H, d, J=8.3 Hz), 6.65 (1H, d, J=8.3 Hz), 7.20-7.35 (5H, m).

IR (KBr)

υ 3428, 3220, 1638, 1615,1502, 1458, 1375, 1330, 1238, 1147, 1116, 1033, 990, 917, 857, 735 cm⁻¹

Mass (EI)

m/z 446 (M+), 355, 286, 160.

Elementary Analysis: As C₂₈H₃₄N₂O₃.0.5H₂O

Calculated values: C, 73.82; H, 7.74; N, 6.15.

Measured values: C, 73.94; H, 7.79; N, 6.08.

Example 5

17-Cyclopropylmethyl-4,5α-epoxy-6β-(N-benzyl)ethylamino-3,14β-dihydroxymorphinan 9 (yield: 46%) was obtained by following the procedure of example 4 but using benzylethylamine instead of benzylmethylamine.

NMR (400 MHz, CDCl₃)

δ 0.05-0.18 (2H, m), 0.46-0.58 (2H, m), 0.77-0.89 (1H, m), 1.03 (3H, t, J=7.1 Hz), 1.22-1.33 (1H, m), 1.41-1.48 (1H, m), 1.55-1.65 (2H, m), 1.86-1.99 (1H, m), 2.11 (1H, dt, J=3.9, 12.2 Hz), 2.20 (1H, dt, J=4.9, 12.2 Hz), 2.33 (1H, dd, J=6.8, 12.7 Hz), 2.36 (1H, dd, J=6.8, 12.7 Hz), 2.50-2.75 (5H, m), 2.98 (1H, d, J=18.6 Hz), 3.03 (1H, d, J=5.9 Hz), 3.56 (1H, d, J=14.4 Hz), 3.87 (1H, d, J=14.4 Hz), 4.59 (1H, d, J=7.8 Hz), 4.85 (2H, brs), 6.50 (1H, d, J=7.8 Hz), 6.63 (1H, d, J=7.8 Hz), 7.18-7.32 (3H, m), 7.40 (2H, d, J=6.8 Hz).

Mass (EI)

m/z 460 M+

Example 6

17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10

12.65 g of 6β-(N-benzyl)methylamino-17-cyclopropylmethyl-4,5α-epoxy-3,14α-dihydroxymorphinan 8.2 hydrochloride (converted to a hydrochloride by established methods) was dissolved in 250 ml of methanol followed by the addition of 2.53 g of 5% palladium-carbon and stirring for 4 hours in a hydrogen atmosphere. After removing the catalyst using Celite, the filtrate was concentrated. 100 ml of a 4:1 solution of chloroform and ethanol and 100 ml of saturated aqueous sodium bicarbonate were added to the resulting residue to separate, and the aqueous layer was then extracted twice with 100 ml of a 4:1 solution of chloroform and ethanol. After drying the organic layer with anhydrous sodium sulfate, the dried organic layer was concentrated to obtain 8.00 g of crude product. This was then recrystallized from methanol to obtain 5.84 g of the target compound (yield: 67%).

NMR (400 MHz, CDCl₃)

δ 0.10-0.14 (2H, m), 0.50-0.55 (2H, m), 0.79-0.86 (1H, m), 1.38 (1H, dt, J=2.9 Hz, 12.8 Hz), 1.41-1.48 (1H, m), 1.58-1.72 (2H, m), 1.78-1.91 (1H, m), 2.08-2.25 (2H, m), 2.36 (1H, d, J=6.6 Hz), 2.45 (3H, s), 2.49-2.65 (3H, m), 3.00 (1H, d, J=18.3 Hz), 3.05 (1H, d, J=5.9 Hz), 4.48 (1H, d, J=7.7 Hz), 6.54 (1H, d, J=8.1 Hz), 6.66 (1H, d, J=8.1 Hz).

IR (KBr)

υ 3380, 2926, 1638, 1607, 1462, 1255, 1180, 795 cm⁻¹

Mass (EI)

m/e 356 M+

Elementary Analysis: C₂₁H₂₈O₃N₂

Calculated values: C, 70.76; H, 7.92; N, 7.86.

Measured values: C, 70.51; H, 7.94; N, 7.84.

Example 7

17-Cyclopropylmethyl-4,5α-epoxy-6β-ethylamino-3,14β-dihydroxymorphinan 11 (yield: 95%) was obtained by following the procedure of example 6 but using 6β-(N-benzyl)ethylamino-17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxymorphinan 9.2 hydrochloride for the starting material instead of 6β-(N-benzyl)methylamino-17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxymorphinan 8.2 hydrochloride.

NMR (500 MHz, CDCl₃+D20)

δ 0.08-0.17 (2H, m), 0.49-0.56 (2H, m), 0.78-0.87 (1H, m), 1.16 (3H, t, J=7.1 Hz), 1.37 (1H, dt, J=2.9, 13.2 Hz), 1.40-1.45 (1H, m), 1.57-1.61 (1H, m), 1.66-1.71 (1H, m), 1.83 (1H, dq, J=2.9, 13.2 Hz), 2.13 (1H, dt, J=12.1, 3.3 Hz), 2.20 (1H, dt, J=12.1, 4.8 Hz), 2.34 (1H, dd, J=12.8, 6.6 Hz), 2.37 (1H, dd, J=12.8, 6.6 Hz), 2.52-2.69 (4H, m), 2.80 (1H, dq, J=11.4, 7.0 Hz), 3.00 (1H, d, J=18.3 Hz), 3.05 (1H, d, J=5.9 Hz), 4.46 (1H, d, J=7.7 Hz), 6.54 (1H, d, J=8.1 Hz), 6.67 (1H, d, J=8.1 Hz).

Mass (EI)

m/e 370 M+

Reference Example 6

17-Allyl-3,14β-dihydroxy-4,5α-epoxy-6α-methylamino-morphinan 12

17-Allyl-3,14β-dihydroxy-4,5β-epoxy-6-methylamino-morphinan 13

Naloxone hydrochloride (3.0 g), methylamine hydrochloride (5.57 g) and sodium cyanoborohydride (0.33 g) were suspended in anhydrous methanol (40 ml) and stirred for 17 hours at room temperature. After addition of concentrated hydrochloric acid (1.0 ml) and removal of solvent by distillation, distilled water (50 ml) was added followed by washing with chloroform (20 ml). Saturated aqueous sodium bicarbonate (10 ml) was added to make the solution basic followed by extraction with chloroform (30 ml×3). After drying with anhydrous magnesium sulfate, the solvent was distilled off. The resulting crude product was purified with silica gel column chromatography (Merk 7734 100 g; ethyl acetate/methanol/aqueous ammonia=90/10/1→80/20/2) to obtain the target compound in the form of a pure fraction (12 0.4 g, 12%; 13 0.8 g, 24%).

Compound 12

NMR (400 MHz, CDCl₃)

δ 0.87 (1H, m), 1.39 (1H, m), 1.66 (3H, m), 2,19 (1H, dt, J=12.2, 4.9 hz), 2.29(1H, dt, J=12.7, 3.4 Hz), 2.55 (3H, m), 2.59 (3H, s), 2.90 (1H, d, J=6.4 Hz), 3.09 (2H, m), 3.18 (1H, m), 4.76 (1H, d, J=3.4 Hz), 4.7-4.9 (1H, br), 5.17 (2H, m), 5.80 (1H, m), 6.50 (1H, d, J=7.8 Hz), 6.69 (1H, d, J=7.8 Hz)

IR (neat)

3400, 1618, 1450, 1386, 1160, 1067, 750 cm⁻¹.

Mass (EI)

m/z 342 (M+)

Compound 13

NMR (500 MHz, CDCl₃)

δ 1.42 (2H, m), 1.61 (2H, m), 1.91 (1H, dq, J=12.8, 3.1 Hz), 2.16 (2H, m), 2.47 (3H, s), 2.56 (3H, m), 2.87 (1H, d, J=5.5 Hz), 3.03 (1H, d, J=18.3 Hz), 3.11 (2H, d, J=6.7 Hz), 4.51 (1H, d, J=7.9 Hz), 4.7-5.2 (3H, br), 5.18 (2H, m), 5.79 (1H, m), 6.55 (1H, d, J=7.9 Hz), 6.64 (1H, d, J=7.9 Hz)

IR (neat)

υ 3400, 1560, 1543, 1458, 1255, 1036, 731 cm⁻¹.

Mass (EI)

m/z 342 (M+)

Reference Example 7

17-Cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methylamino)morphinan (yield: 40%) 14, and 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(N-methylamino)morphinan (yield: 23%) 15 were obtained by following the procedure of reference example 6 but using 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxymorphinan-6-one instead of naloxone hydrochloride.

Compound 14

NMR (500 MHz, CDCl₃)

δ 0.13-0.18 (2H, m), 0.53-0.59 (2H, m), 0.88 (1H, m), 1.78 (1H, d, J=7.8 Hz), 2.38 (2H, d, J=7.8 Hz), 2.40 (1H, d, J=6.3 Hz), 2.44 (1H, dd, J=12.7, 6.3 Hz), 2.50 (1H, dd, J=18.6, 6.8 Hz), 2.58 (3H, s), 2.72 (1H, d, J=7.8 Hz), 3.08 (1H, d, J=18.6 Hz), 3.35 (1H, d, J=6.8 Hz), 3.65 (1H, m), 3.84 (3H, s), 4.97 (1H, br), 4.99 (1H, dd, J=5.9, 1.5 Hz), 5.54 (1H, dd, J=9.8, 2.9 Hz), 5.88 (1H, dt, J=9.8, 1.5 Hz), 6.51 (1H, d, J=7.8 Hz), 6.63 (1H, d, J=7.8 Hz).

IR (neat)

υ 3342, 2938, 1508, 1456, 1284, 1205, 1123, 1054, 1017, 748 cm⁻¹

Mass (EI)

m/z 368 (M+)

Compound 15

mp 121.5-123.5° C. (ethylacetate-ether)

NMR (400 MHz, CDCl₃)

δ 0.09-0.16 (2H, m), 0.50-0.56 (2H, m), 0.84 (1H, m), 1.36 (1H, td, J=12.7, 3.9 Hz), 1.44 (1H, dd, J=12.7, 2.4 Hz), 1.61 (1H, dt, J=13.2, 3.4 Hz), 1.66-1.83 (2H, m), 2.10 (1H, td, J=12.2, 3.9 Hz), 2.23 (1H, td, J=12.2, 4.9 Hz), 2.36 (2H, dd, J=6.4, 1.5 Hz), 2.43 (1H, m), 2.48 (3H, s), 2.57-2.66 (2H, m), 3.03 (1H, d, J=18.6 Hz), 3.08 (1H, d, J=5.9 Hz), 3.87 (3H, s), 4.45 (1H, d, J=6.8 Hz), 6.61 (1H, d, J=8.3 Hz), 6.72 (1H, d, J=8.3 Hz).

IR (KBr)

υ 3390, 3344, 2944, 2802, 1632, 1611, 1504, 1446, 1282, 1263, 1044, 980, 901 cm⁻¹

Mass (EI)

m/z 370 (M+).

Reference Example 8

3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α- (N-methyl-3,4-dichlorophenylmethanesulfonamido)morphinan 16

203.9 mg of 3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-methylaminomorphinan 7 obtained in reference example 5 was dissolved in 3 ml of pyridine followed by the addition of 124 mg of 3,4-dichorophenylmethanesufonylchloride and stirring for 30 minutes at room temperature. After concentrating the reaction system, 3 ml of saturated aqueous sodium bicarbonate and 3 ml of chloroform were added to separate layers, after which the aqueous layer was extracted twice with 3 ml of chloroform. After drying with anhydrous sodium sulfate, the organic layer was concentrated to obtain the oily crude product. This was then purified with silica gel column chromatography (30 g benzene/ethyl acetate=5/1) to obtain 235.4 mg of the target compound (yield: 78%).

NMR (500 MHz, CDCl₃)

δ 0.09-0.16 (2H, m), 0.15 (3H, s), 0.21 (3H, s), 0.51-0.57 (2H, m), 0.80-0.89 (1H, m), 0.97 (9H, s), 1.21-1.30 (2H, m), 1.42-1.49 (2H, m), 1.71 (1H, dt, J=14.7, 9.5 Hz), 2.15 (1H, dt, J=12.5, 5.1 Hz), 2.22 (1H, dt, J=12.5, 3.7 Hz), 2.30 (1H, dd, J=12.8, 6.6 Hz), 2.35 (1H, dd, J=12.8, 6.6 Hz), 2.56 (1H, dd, J=18.7, 7.0 Hz), 2.60-2.65 (1H, m), 2.89 (3H, s), 3.01 (1H, d, J=18.7 Hz), 3.05 (1H, d, J=7.0 Hz), 4.16 (1H, d, J=13.9 Hz), 4.19 (1H, d, J=13.9 Hz), 4.22-4.28 (1Hm), 4.41 (1H, d, J=3.3 Hz), 4.90 (1H, brs), 6.48 (1H, d, J=8.1 Hz), 6.62 (1H, d, J=8.1 Hz), 7.31 (1H, dd, J=8.1, 2.2 Hz), 7.46 (1H, d, J=8.1 Hz), 7.53 (1H, d, J=2.2 Hz).

Mass (EI)

m/z 692 M+

Reference Example 9

3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan 17 (yield: 50%) was obtained by following the procedure of reference example 8 but using phenylmethanesulfonylchloride instead of 3,4- dichlorophenylmethanesulfonylchloride.

NMR (500 MHz, CDCl₃)

δ 0.08-0.13 (2H, m), 0.14 (3H, s), 0.20 (3H, s), 0.50-0.55 (2H, m), 0.79-0.87 (1H, m), 0.97 (9H, s), 1.10-1.22 (2H, m), 1.37-1.43 (2H, m), 1.64 (1H, dt, J=15.0, 9.5 Hz), 2.12 (1H, dt, J=12.5, 5.1 Hz), 2.20 (1H, dt, J=12.5, 3.3 Hz),2.29 (1H, dd, J=12.5, 6.6 Hz), 2.33 (1H, dd, J=12.5, 6.6 Hz), 2.54 (1H, dd, J=18.7, 7.0 Hz), 2.59-2.63 (1H, m), 2.83 (3H, s), 2.99 (1H, d, J=18.7 Hz), 3.02 (1H, d, J=7.0 Hz), 4.19-4.24 (1H, m), 4.24 (1H, d, J=13.9 Hz), 4.28 (1H, d, J=13.9 Hz), 4.34 (1H, d, J=2.9 Hz), 4.88 (1H, brs), 6.46 (1H, d, J=8.1 Hz), 6.61 (1H, d, J=8.1 Hz), 7.32-7.40 (3H, m), 7.42-7.47 (2H, m).

Mass (EI)

m/z 624 M+

Reference Example 10

5β-Methylnaltrexone-O-methyloxime(17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-5β-methyl-6-methoxyiminomorphinan) 18

109.3 mg of 5β-methylnaltrexone (0.326 mmol) and 37.2 mg of methoxyamine hydrochloride (0.445 mmol) were dissolved in 1.6 ml of methanol followed by the addition of 0.17 ml of 10% aqueous sodium hydroxide to this solution and refluxing while heating. After 8.5 hours part way through the refluxing period, a solution of 36.1 mg (0.432 mmol) of methoxyamine hydrochloride in 0.5 ml of methanol was added and refluxing was continued until a total of 23 hours had elapsed. After allowing the reaction solution to cool to room temperature by standing, 5 ml of water and 1 ml of saturated aqueous sodium bicarbonate were added followed by extraction with 2×5 ml of chloroform. The organic layers were combined and dried with anhydrous sodium sulfate followed by concentration to obtain 107.4 mg of the unpurified target compound. This unpurified compound was used in the following reaction without being purified.

NMR (400 MHz, CDCl₃)

δ 0.13 (2H, m), 0.53 (2H, m), 0.84 (1H, m), 1.37 (1H, m), 1.43 (1H, dd, J=14.1, 3.4 Hz), 1.62 (1H, m), 1.71 (3H, s), 2.23-2.30 (3H, m), 2.30 (1H, br s, OH), 2.37 (2H, d, J=6.5 Hz), 2.55 (1H, dd, J=18.3, 6.1 Hz), 2.71 (1H, m),3.00 (1H, d, J=18.3 Hz), 3.04 (1H, d, J=6.1 Hz), 3.14 (1H, ddd, J=14.7, 3.2, 3.2 Hz), 3.80 (3H, s), 4.95 (1H, br s, OH), 6.55 (1H, d, J=8.0 Hz), 6.70 (1H, d, J=8.0 Hz).

IR (KBr)

υ 3380, 1638, 1620, 1510, 1460, 1377, 1336, 1241, 1118, 1038, 953, 866, 752 cm⁻¹

Mass (EI)

m/z 384 (M+).

Reference Example 11

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-5β-methyl-6α-aminomorphinan 19

101.0 mg (approximately 0.26 mmol) of the unpurified 5β-methylnaltrexone-O-methyloxime 18 a obtained in reference example 10 was dissolved in 2.5 ml of anhydrous THF in the presence of argon gas followed by cooling to 0° C. After adding 1.31 ml of an anhydrous THF solution of 1.0 M borane.THF complex to this solution, the solution was refluxed for 18.5 hours while heating. After cooling the reaction solution to 0° C. and slowly adding 10 ml of 2 N hydrochloric acid, the solution was again refluxed for 40 minutes while heating. The reaction solution was cooled to 0° C. followed by the addition of 4 ml of 5 N aqueous ammonia and 2 ml of saturated aqueous sodium bicarbonate, and extraction with 3×5 ml of chloroform-methanol (4:1). The organic layers were combined and dried with anhydrous sodium sulfate followed by concentration to obtain 89.6 mg of the unpurified target compound. This unpurified compound was then used in the following reaction without being purified.

NMR (400 MHz, CDCl₃)

δ 0.12 (2H, m), 0.53 (2H, m), 0.83 (1H, m), 1.37-1.84 (5H, m), 1.63 (3H, s), 2.15-2.28 (2H, m) 2.33 (2H, d, J=5.7 Hz), 2.60 (1H, dd, J=18.5, 6.3 Hz), 2.67 (1H, m), 2.99 (1H, d, J=18.5 Hz), 3.00 (3H, br s, OH, NH2), 3.02 (1H, d, J=6.3 Hz), 3.14 (1H, dd, J=8.8, 3.8 Hz), 4.90 (1H, br s, OH), 6.49 (1H, d, J=8.0 Hz), 6.63 (1H, d, J=8.0 Hz).

IR (KBr)

υ 3376, 3082, 1611, 1502, 1460, 1379, 1332, 1245, 1122, 1038, 944, 868, 803 cm⁻¹.

Mass (EI)

m/z 356 (M+).

Example 8

6β-(N-Benzyl)methylamino-17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxymorphinan 8

50.08 g (0.108 mol) of naltrexone benzoate was suspended in THF (350 ml) followed by the addition of 19.61 g (0.162 mol) of benzylmethylamine. A Soxhlet extractor containing molecular sieves 4A (50 g) was attached followed by refluxing for 23 hours while heating. After adding methanol (200 ml) to the reaction system, 10.2 g (0.162 mol) of sodium cyanoborohydride was dissolved in methanol (50 ml) and added to the reaction mixture followed by stirring for 30 minutes. After stirring, the solvent was distilled off and ethylacetate (400 ml) and 1% aqueous sodium bicarbonate (400 ml) were added to the residue to separate layers. The aqueous layer was re-extracted with ethylacetate (80 ml). The resulting organic layer was washed with saturated brine (250 ml) and concentrated after drying. Methanol (240 ml) was added to the resulting residue to recrystallize and obtain 42.68 g of the target substance (yield: 88%). The data of this compound is the same as that shown in example 4.

Example 9

An isomer mixture of 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6β-methylaminomorphinan 20 and 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-methylaminomorphinan 21 (20:21=approximately 2:1, 44%) was obtained by following the procedure of example 8 but using 14-dehydroxynaltrexone instead of naltrexone benzoate.

Mixture of Compound 20 and Compound 21

NMR (400 MHZ, CDCl₃)

δ 0.08-0.17 (2H, m), 0.49-0.55 (2H, m), 0.8-2.5 (12H), 2.42 (2.1H, s), 2.54 (0.9H, s), 2.7-2.9 (2H), 3.36 (0.7H, m), 3.41 (0.3H, m), 4.36 (0.7H, d, J=7.3 Hz), 4.78 (0.3H, d, J=2.9 Hz), 6.48-6.56 (1H, m), 6.64-6.68 (1H, m)

IR (neat)

υ 2932, 1609, 1454, 1325, 1259, 911, 731 cm⁻¹

Mass (EI)

m/z 340 (M+)

Example 10

17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10. phthalate

42.58 g (0.0953 mol) of 6β-(N-benzyl)methylamino-17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxymorphinan 8 and 17.42 g (0.105 mol) of phthalic acid were dissolved in 500 ml of methanol followed by the addition of 12.7 g of 10% palladium-carbon and stirring for 12 hours in a hydrogen atmosphere. After the atmospheric hydrogen was replaced to nitrogen, 300 ml of methanol was added followed by refluxing while heating. After dissolving the precipitated crystals, the catalyst was filtered out during heating using Celite. After distilling off 200 ml of filtrate by atmospheric pressure condensation, the remaining filtrate was allowed to stand undisturbed to recrystallize and obtain 26.82 g of the target compound (yield: 54%).

mp 151-164° C. (decomposition)

NMR (400 MHz, D20)

δ 0.40-0.50 (2H, m), 0.73 (1H, m), 0.82 (1H, m), 1.08 (1H, m), 1.56 (1H, m), 1.67 (1H, m), 1.85 (1H, m), 1.89-2.02 (2H, m), 2.52 (1H, ddd, J=13.2, 13.2, 4.9 Hz), 2.75 (1H, ddd, J=12.9, 12.9, 4.2 Hz), 2.78 (3H, s), 2.93-3.04 (2H, m), 3.16-3.25 (2H, m), 3.32-3.43 (2H, m), 4.07 (1H, br d, J=5.9 Hz), 4.99 (1H, d, J=7.3 Hz), 6.85 (1H, d, J=8.0 Hz), 6.90 (1H, d, J=8.0 Hz), 7.34-7.39 (2H, m), 7.43-7.48 (2H, m).

IR (KBr)

υ 3388, 3032, 1605, 1557, 1510, 1460, 1367, 1330, 1243, 1168, 1120, 1035, 992, 936, 859, 770 cm⁻¹.

Mass (FAB)

m/z 357 ((M+H)+).

Elementary Analysis: As C₂₁H₂₈N₂O₃.C₈H₆O₄.0.8H₂O

Calcd.: C, 64.86; H. 6.68; N, 5.22.

Found.: C, 64.93; H, 6.61; N, 5.23.

Example 11

17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-N-methyl-3,4-dichlorophenylacetoamido)morphinan.hydrochlorid

8.9 g of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4 obtained in example 1 was dissolved in 180 ml of chloroform. After adding 10.4 ml of triethylamine, 10.4 ml of 3,4-dichlorophenylacetyl chloride (obtained by converting commercially available carboxylic acid into an acid chloride by established methods) was added dropwise at 0° C. After completion of dropwise addition, the reaction solution was stirred for 1 hour at room temperature followed by the addition of 150 ml of saturated aqueous sodium bicarbonate to the reaction system to separate. The aqueous layer was then extracted twice with 100 ml of chloroform. After drying with anhydrous sodium sulfate, the organic layer was concentrated. The resulting residue was dissolved in a mixed solvent of 140 ml of methanol and 14 ml of chloroform followed by the addition of 1.7 g of potassium carbonate at room temperature and stirring for 30 minutes. 100 ml of water and 350 ml of chloroform were then added to the reaction solution to separate layers, and the aqueous layer was extracted twice with 80 ml of chloroform. After drying with anhydrous sodium sulfate, the resulting organic layer was concentrated. The resulting residue was recrystallized from a 2:1 mixture of ethylacetate and methanol to obtain 8.15 g of the free base form. This was then dissolved in a mixed solvent of chloroform and methanol followed by concentration after adjusting to pH 3 by addition of methanol solution of hydrochloride. This solution was re-precipitated from chloroform, methanol and ether to obtain 8.44 g of the target compound (yield: 58%).

mp 252-254° C.

NMR (400 MHz, DMSO-d₆)

δ 0.43 (2H, m), 0.65 (2H, m), 1.05 (1H, m), 1.16 (1.5H, m), 1.37 (1H, m), 1.58 (2H, m), 1.92 (1H, m), 2.43 (1H, m), 2.68 (1H, m), 2.81 (0.5H, s), 2.96 (2.5H, s), 3.05 (2.5H, m), 3.30 (2H, m), 3.85 (3H, m), 4.48 (0.2H, m), 4.62 (0.8H, d, J=3.9 Hz), 4.75 (0.2H, m), 4.96 (0.8H, m), 6.21 (0.8H, m), 6.46 (0.2H, m), 6.58 (1H, d, J=8.3 Hz), 6.72 (1H, d, J=8.3 Hz), 7.25 (1H, m), 7.55 (2H, m), 8.80 (1H, brs), 9.32 (1H, brs)

IR (KBr)

υ 3370, 1620, 1510, 1473, 1120, 1035, cm⁻¹.

Mass (FAB)

m/z 543 (M+H)+

Elementary Analysis: As C₂₉H₃₂N₂O₄Cl₂. HCl.0.5H₂O

Calcd.: C, 59.14; H, 5.82; N, 4.75; Cl, 18.06

Found.: C, 59.34; H, 5.78; N, 4.78; Cl, 17.78

Examples 12-40

17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-phenylpropionamido)morphinan.tartrate 22 (yield: 84%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylphenylacetamido)morphinan.hydrochloride 23 (yield: 70%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylcinnamamido)morphinan.hydrochloride 24 (yield: 74%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylacetamido)morphinan.hydrochloride 25 (yield: 93%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-bromophenylacetamido)morphinan.hydrobromate 26 (yield: 85%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-dichlorobenzamido) morphinan.hydrochloride 27 (yield: 58%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-bromophenylacetamido)morphinan.hydrobromide 28 (yield: 73%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[(R)-N-methyl-2-phenylpropionamido]morphinan.hydrochloride 29 (yield: 52%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α([(R)-N-methylmethoxyphenylacetamido]morphinan.hydrochloride 30 (yield: 98%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[(s)-N-methylmethoxyphenylacetamido]morphinan.hydrochloride 31 (yield: 70%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α- [(s)-N-methyl-2-phenylpropionamido]morphinan.tartrate 32 (yield: 85%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylcyclohexylcarboxyamido) morphinan.hydrochloride 33 (yield: 58%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl benzamido)morphinan.hydrochloride 34 (yield: 52%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-phenylbutyramido)morphinan.hydrochloride 35 (yield: 80%), 17-cyclopropylmethyl3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-6-phenylhexanamido)morphinan.hydrochloride 36 (yield: 63%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-fluorophenylacetamido)morphinan.hydrochloride 37 (yield: 57%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylphenoxyacetamido) morphinan.hydrochloride M (yield: 86%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylhexanamido)morphinan.tartrate 39 (yield: 68%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylheptanamido)morphinan.tartrate 40 (yield: 81%), 17-cyclopropylmethyl-3,14,β-dihydroxy-4,5α-epoxy-6α- [N-methyl-3-(3-pyridyl)propionamido]morphinan.tartrate 41 (yield: 65%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylbenzyloxycarbamido)morphinan.tartrate 42 (yield: 61%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-nitrobenzyloxycarbamido)morphinan.hydrochloride 43 (yield: 68%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-(3-pyridyl)methyloxycarbamido]morphinan.tartrate 44 (yield: 31%), 17-cyclopropylmethyl-4,5α-epoxy-3,14,β-dihydroxy-6α-(N-methylthiophenoxyacetamido)morphinan.tartrate 45 (yield: 50%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylheptanamido)morphinan.hydrochloride 46 (yield: 62%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylbutyroxycarbamido)morphinan.tartrate 47 (yield: 70%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3-cyclopentylpropionamido) morphinan.tartrate 48 (yield: 84%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-2-methoxyethoxycarbamido)morphinan.tartrate 49 (yield: 70%), and 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-trans-3-cyclohexylacrylamido)morphinan.hydrochloride 50 (yield: 72%) were obtained by following the procedure of example 11, but using 3-phenylpropionyl chloride, phenylacetyl chloride, trans-cinnamoyl chloride, acetyl chloride, 3-bromophenylacetyl chloride, 3,4-dichlorobenzoyl chloride, 4-bromophenylacetyl chloride, R-(−)-2-phenylpropionyl chloride, R-(−)-methoxyphenylacetyl chloride, S-(+)-methoxyphenylacetyl chloride, S-(+)-2-phenylpropionyl chloride, cyclohexanecarbonyl chloride, benzoyl chloride, 4-phenylbutanoyl chloride, 6-phenylhexanoyl chloride, 3-fluorophenylacetyl chloride, phenoxyacetyl chloride, hexanoyl chloride, heptanoyl chloride, 3-(3-pyridyl)propionyl chloride, benzyl chloroformate, 4-nitrobenzyl chloroformate, 3-pyridylmethyl chloroformate, thiophenoxyacetyl chloride, heptanoyl chloride, butyl chloroformate, 3-cyclopentylpropionyl chloride, 2-methoxyethyl chloroformate and trans-3-cyclohexylacryloyl chloride instead of 3,4-dichlorophenylacetyl chloride.

Compound 22

mp>203° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.13-0.27 (2H, m), 0.47-0.59 (2H, m), 0.80-0.95 (1H, m), 1.06-1.57 (5H, m), 1.68-1.79 (1H, m), 1.95-2.33 (2H, m), 2.57-2.89 (6H, m), 2.88 (2.1H, s), 3.17 (0.9H, s), 3.00-3.53 (3H, m), 3.45 (3H, brs), 4.09 (1H, s), 4.29-4.36 (0.3H, m), 4.54 (0.7H, d, J=3.7 Hz). 4.54-4.59 (0.3H, m), 4.92 (0.7H, m), 6.51 (0.7H, d, J=8.0 Hz), 6.49-6.52 (0.3H, m), 6.62 (1H, d, J=8.0 Hz), 7.05-7.31 (5H, m), 9.10 (1H, brs).

IR (KBr)

υ 3420, 1605, 1460, 1174, 1120, 1073, 1036 cm⁻¹.

Mass (EI)

m/z=488 M+.

Elementary Analysis: As C₃₀H₃₆N₂O₄.0.5C₄H₆O₆.0.2H₂O

Calcd.: C, 67.75; H, 7.00; N, 4.94.

Found.: C, 67.79; H. 7.09; N, 5.04.

Compound 23

mp 253.0-257.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 6 0.40 (1H, m)), 0.47 (1H, m), 0.60 (1H, m), 0.69 (1H, m), 1.05 (1H, m), 1.09 (1H, m), 1.34 (1H, m), 1.47 (1H, m), 1.56 (1H, dd, J=14.7, 9.3 Hz), 1.61 (1H, d, J=13.7 Hz), 1.91 (1H, m), 2.36˜2.52 (2H, m), 2.69 (1H, m), 2.80 (0.8H, s), 2.93 (1H, m), 2.95 (2.2H, s), 3.15 (1H, d, J=12.2 Hz), 3.09 (1H, dd, J=19.8, 7.1 Hz), 3.76 (2H, s), 3.89 (1H, br s), 4.27 (0.27H, s), 4.51 (0.27H, m), 4.63 (0.73H, d, J=3.4 Hz), 5.00 (0.73H, dt, J=13.7, 3.4 Hz), 6.20 (0.73H, brs), 6.40 (0.27H, m), 6.58 (1H, d, J=8.3 Hz), 6.72 (1H, dd, J=8.3, 2.0 Hz), 7.22˜7.29 (2H, m), 7.30˜7.38 (3H, m), 8.80 (1H, br s), 9.29 (1H, d, J=5.9 Hz).

IR (KBr)

υ 3400, 3100, 2952, 1620, 1508, 1475, 1319, 1120, 1036, 806 cm⁻¹.

Mass (FAB)

m/z 475 (M+H)+.

Elementary Analysis: As C₂₉H₃₅N₂O₄Cl.0.3H₂O

Calcd.: C, 67.44; H, 6.95; N, 5.43; Cl, 6.86.

Found.: C, 67.45; H, 7.15; N, 5.40; Cl, 6.99.

Compound 24

mp 254-257° C.

NMR (400 MHz, DMSO-d₆)

δ 0.21 (2H, m), 0.52 (2H, m), 0.91 (1H, m), 1.20 (1.5H, m), 1.48 (3H, m), 1.78 (1H, m), 2.26 (2.5H, m), 2.58 (1H, m), 2.73 (2H, m), 2.91 (0.5H, s), 3.06 (1H, m), 3.09 (2.5H, m), 3.20-3.90 (4H, br), 4.03 (1H, s), 4.5-5.1 (2H, m), 6.52 (1H, d, J=7.9 Hz), 6.62 (1H, d, J=7.9 Hz), 7.09 (0.2H, d, J=15.9 Hz), 7.23 (0.8H, d, J=15.9 Hz), 7.40-7.60 (4H, m), 7.60-7.80 (2H, m), 8.80-9.20 (1H, br).

IR (KBr)

υ 3400, 1644, 1593, 1317, 1118, 1038, 768 cm⁻¹.

Mass (FAB)

m/z 487 (M+H)

Elementary Analysis: As C₃₂H₃₇N₂O₇.0.8H₂O

Calcd.: C, 66.72; H, 6.75; N, 4.86

Found.: C, 66.56; H, 6.74; N, 5.08

Compound 25

mp>300.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.48 (1H, m), 0.61 (1H, m), 0.69 (1H, m), 1.05 (1H, m), 1.13 (1H, m), 1.33 (1H, m), 1.55 (1H, dd, J=15.3, 9.8 Hz), 1.59 (1H, d, J=14.0 Hz),1.92 (1H, dt, J=15.3, 9.5 Hz), 2.05 (2.5H, s), 2.13 (0.5H, s), 2.43 (1H, dt, J=13.4, 4.9 Hz), 2.69 (1H, m), 2.77 (0.5H, s), 2.89 (2.5H, s), 2.94 (1H, dd, J=13.1, 7.0 Hz), 3.03 (1H, br d, J=10.3 Hz), 3.09 (1H, dd, J=20.1, 7.3 Hz), 3.24˜3.38 (2H, m), 3.91 (1H, d, J=6.7 Hz), 4.37 (0.17H, br d, J=12.2 Hz), 4.61 (0.83H, d, J=4.3 Hz), 4.81 (0.17H, d, J=4.3 Hz), 4.94 (0.83H, dt, J=14.0, 3.7 Hz), 6.26 (0,83H, s), 6.46 (0.17H, s), 6.58 (1H, d, J=8.2 Hz), 6.73 (1H, dd, J=8.2, 1.8 Hz), 8.82 (1H, br s), 9.31 (1H, s).

IR (KBr)

υ 3400, 3100, 2866, 1618, 1500, 1301, 1172, 1120, 1038, 920 cm⁻¹.

Mass (FAB)

m/z 399 (M+H)+.

Elementary Analysis: As C₂₃H₃₀N₂O₄.1.12HCl.0.5H₂O

Calcd.: C, 61.61; H, 7.22; N, 6.25; Cl, 8.86.

Found.: C, 61.43; H, 7.21; N, 6.33; Cl, 9.00.

Compound 26

mp 200.0-205.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.46 (1H, m), 0.60 (1H, m), 0.68 (1H, m), 1.03 (1H, m), 1.15 (1H, m), 1.36 (1H, m), 1.53˜1.65 (2H, m), 1.87 (1H, m), 2.41 (1H, m), 2.68 (1H, m), 2.80 (0.4H, s), 2.96 (2.6H, s), 2.87˜3.12 (3H, m), 3.20˜3.35 (2H, m), 3.79 (2H, s), 3.85 (1H, m), 4.63 (0.87H, d, J=3.4 Hz), 4.65 (0.13H, m), 4.97 (1H, dt, J=13.7, 3.4 Hz), 6.13 (0.87H, s), 6.22 (0.13H, s), 6.59 (1H, d, J=8.3 Hz), 6.71 (1H, d, J=8.3 Hz), 7.25 (1H, d, J=7.8 Hz), 7.29 (1H, t, J=7.8 Hz), 7.45 (1H, d, J=7.8 Hz), 7.46 (1H, s), 8.76 (1H, br s), 9.29 (1H, s).

IR (KBr)

υ 3400, 2952, 1626, 1506, 1407, 1319, 1120, 1036, 919, 772, 748 cm⁻¹

Mass (FAB)

m/z 553 (M+H)+.

Elementary Analysis: As C₂₉H₃₄N₂O₄Br₂.0.4H₂O

Calcd.: C, 54.29; H. 5.48; N, 4.37; Br, 24.91.

Found.: C, 54.04; H, 5.63; N, 4.34; Br, 25.19.

Compound 27

mp 230° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.32-0.74 (4H, m), 0.93-1.11 (1H, m), 1.12-1.42 (2H, m), 1.45-1.78 (3H, m), 1.94-2.22 (1H, m), 2.65-2.76 (1H, m), 2.86 (2.4H, s), 2.91-3.15 (3.6H, m), 3.20-3.40 (2H, m), 3.79 (0.2H, m), 3.94 (0.8H, m), 4.24 (0.2H, m), 4.62 (0.2H, m), 4.85 (0.8H, m), 4.98 (0.8H, m), 5.97 (0.2H, br s), 6.35 (0.8H, br s), 6.59 (1H, d, J=7.9 Hz), 6.73 (1H, d, J=7.9 Hz), 7.40-7.50 (1H, m), 7.69-7.79 (2H, m), 8.66 (0.2H, br s), 8.88 (0.8H, br s), 9.31 (0.8H, br s), 9.38 (0.2H, br s).

IR (KBr)

υ 3152, 1626, 1508, 1473, 1408, 1379, 1315, 1033 cm⁻¹.

Mass (FAB)

m/z 529 ((M+H) +)

Elementary Analysis: As C₂₈H₃₀N_(O) ₄Cl₂.HCl.0.2H₂O

Calcd.: C, 59.05; H, 5.56; N, 4.92; Cl, 18.67.

Found.: C, 58.93; H, 5.68; N, 4.90; Cl 18.54.

Compound 28

mp 210° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.45 (2H, m), 0.64 (2H, m), 1.07 (1H, m), 1.15 (2H, m), 1.35 (1H, m), 1.58 (2H, m), 1.90 (1H, m), 2.42 (1H, m), 2.67 (1H, m), 2.80 (0.5H, s), 2.92 (1H, m), 2.95 (2.5H, s), 3.10 (2H, m), 3.31 (1H, m), 3.80 (3H, m), 4.4-5.0 (2H, m), 6.14 (0.8H, brs), 6.23 (0.2H, brs), 6.59 (1H, d, J=8.6 Hz), 6.72 (1H, d, J=8.6 Hz), 7.21 (2H, m), 7.52 (2H, m), 8.76 (1H, brs), 9.0-9.5 (1H, br)

IR (KBr)

υ 3320, 1620, 1466, 1321, 1120, 803 cm⁻¹.

Mass (FAB)

m/z 553 (M+H)

Elementary Analysis: As C₂₉H₃₃N₂O₄Br.HBr.0.5H₂O

Calcd.: C, 54.14; H, 5.48; N, 4.35; Br, 24.84

Found.: C, 53.90; H, 5.42; N, 4.30; Br, 25.21

Compound 29

mp>203° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.35-0.75 (4H, m), 1.07-1.15 (3H, m), 1.33 (3H, d, J=6.8 Hz), 1.40-1.67 (2H, m), 1.84-2.15 (1.4H, m), 2.43-2.75 (0.6H, m), 2.80 (0.9H, s), 2.81 (2.1H, s), 2.90-3.15 (3H, m), 3.20-3.50 (3H, m), 3.85-3.95 (1H, m)r, 4.12-4.28 (l_(H,) m), 4.53-4.70 (1.3H, m), 4.95-5.05 (0.7H, m), 6.25 (0.7H, brs), 6.40-6.60 (1.3H, m), 6.66 (0.3H, d, J=8.3 Hz), 6.71 (0.7H, d, J=7.8 Hz), 7.18-7.42 (5H, m), 8.80-8.95 (1H, brs), 9,21 (0.3H, s), 9.30 (0.7H, s).

IR (KBr)

υ 3420, 1620, 1508, 1460, 1120, 1067, 1036, 704 cm⁻¹

Mass (FAB)

m/z 489 (M+H)+.

Elementary Analysis: As C₃₀H₃₆N₂O₄.HCl.3H₂O

Calcd.: C, 67.92; H, 7.14; N, 5.28; Cl, 6.68.

Found.: C, 68.05; H, 7.21; N, 5.39; Cl, 6.31.

Compound 30

mp 207.0-211.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.39 (1H, m), 0.47 (1H, m), 0.61 (1H m), 0.68 (1H, m), 1.07 (1H, m), 1.22 (1H, m), 1.39 (1H, m), 1.50 (1H, dd, J=15.1, 9.3 Hz), 1.63 (1H, d, J=11.2 Hz), 1.90 (1H, m), 2.30 (0.15H, dt, J=13.2, 4.9 Hz), 2.47 (0.85H, dt, J=13.2, 4.9 Hz), 2.64 (1H, m), 2.81 (0.45H, s), 2.88 (2.55H, s), 2.95˜3.10 (3H, m), 3.20˜3.35 (2H, m), 3.30 (0.45H, s), 3.40 (2.55H, s), 3.78 (0.15H, br s), 3.92 (0.85H, br d, J=6.8 Hz), 4.64 (0.15H, br d, J=12.7 Hz), 4.69 (1H, d, J=3.4 Hz), 4.95 (0.85H, br d, J=13.7 Hz), 5.26 (0.85H, s), 5.35 (0.15H, s), 6.28 (0.85H, s), 6.54 (0.15H, d, J=8.3 Hz), 6.57 (0.85H, d, J=8.3 Hz), 6.63 (0.15H, s), 6.69 (0.15H, d, J=8.3 Hz), 6.72 (0.85H, d, J=8.3 Hz), 7.31˜7.46 (5H, m), 8.86 (0.85H, br s), 8.92 (0.15H, br s), 9,27 (0.15H, s), 9.34 (0.85H, s).

IR (KBr)

υ 3400, 1638, 1460, 1321, 1120, 1035, 600, 418 cm⁻¹

Mass (FAB)

m/z 505 (M+H)+.

Elementary Analysis: As C₃₀H₃₇N₂O₅Cl.0.4H₂O

Calcd.: C, 65.72; H, 6.95; N, 5.11; Cl, 6.47.

Found.: C, 65.77; H, 7.14; N, 5.23; Cl, 6.41.

Compound 31

mp 270.0-275.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.48 (1H, m), 0.62 (1H, m), 0.69 (1H, m), 1.07 (1H, m), 1.11 (1H, m), 1.35 (1H, m), 1.50 (1H, t, J=14.5 Hz), 1.57 (1H, t, J=15.6 Hz), 1.86 (0.22H, m), 1.97 (0.78H, m), 2.44 (1H, dt, J=13.2, 4.4 Hz), 2.66 (1H, m), 2.80 (0.66H, s), 2.88 (2.34H, s), 2.96˜3.12 (3H, m), 3.24˜3.37 (2H, m), 3.30 (2.34H, s), 3.38 (0.66H, s), 3.92 (1H, d, J=5.9 Hz), 4.27 (0.22H, d, J=1.5 Hz), 4.56 (0.78H, d, J=3.4 Hz), 4.75 (0.22H, m), 5.07 (0.78H, br d, J=13.7 Hz), 5.19 (0.78H, s), 5.24 (0.22H, s), 6.31 (0.78H, s), 6.50 (0.22H, s), 6.56 (1H, d, J=8.3 Hz), 6.71 (1H, d, J=8.3 Hz), 7.34˜7.43 (5H, m), 8.85 (1H, br s), 9.27 (0.78H, s), 9.30 (0.22H, s).

IR (KBr)

υ 3500, 3100, 2942, 2346, 1638, 1508 1475, 1319, 1176, 1120, 1036, 905 cm⁻¹.

Mass (FAB)

m/z 505 (M+H)+.

Elementary Analysis: As C₃₀H₃₇N₂O₅Cl.0.3H₂O

Calcd.: C, 65.93; H, 6.94; N, 5.13; Cl, 6.49.

Found.: C, 65.89; H. 7.02; N, 5.12; Cl, 6.53.

Compound 32

mp 162-165° C.

NMR (400 MHz, DMSO-d₆)

δ 0.21 (2H, m), 0.53 (2H, m), 0.91 (1H, m), 1.09 (1H, m), 1.28 (3H, d, J=6.4 Hz), 1.3-1.5 (3.3H, m), 1.75 (0.7H, m), 2.2-2.3 (2H, m), 2.4-2.8 (4H, m), 2.78 (1H, s), 2.84 (2H, s), 3.0-3.3 (2H, m), 4.04 (1H, s), 4.0-4.1 (1H, m), 4.4-5.1 (2H, m), 6.47 (1H, m), 6.59 (1H, m), 7.2-7.4 (5H, m)

IR (KBr)

υ 3400, 1620, 1462, 1120, 1067, 702 cm⁻¹.

Mass (FAB)

m/z 489 (M+H)

Elementary Analysis: As C₃₂H₃₉N₂O₇.0.4H₂O

Calcd.: C, 67.33; H. 7.03; N, 4.91

Found.: C, 67.28; H, 7.26; N, 4.90

Compound 33

mp>260° C. (decomposition, methanol-ether)

NMR (400 MHz, CD₃OD; data only for major amide form (approximately 90%))

δ 0.49 (2H, m), 0.73 (1H, m), 0.83 (1H, m), 1.08 (1H, m), 1.22-1.57 (7H, m), 1.62-1.98 (8H, m), 2.57-2.74 (2H, m), 2.83-3.02 (2H, m), 3.04-3.20 (2H, m), 3.06 (3H, s), 3.22-3.39 (2H, m), 3.97 (1H, m), 4.74 (1H, m), 5.08 (1H, ddd, J=14.7, 3.9, 3.9 Hz), 6.67 (1H, d, J=8.3 Hz), 6.75 (1H, d, J=8.3 Hz).

IR (KBr)

υ 3366, 1607, 1510, 1473, 1319, 1197, 1118, 1038, 907, 804 cm⁻¹.

Mass (FAB)

m/z 467 ((M+H)+)

Elementary Analysis: As C₂₈H₃₈N₂O₄.HCl

Calcd.: C, 66.85; H, 7.81; N 5.57; Cl, 7.05.

Found.: C, 66.87; H, 7.90; N, 5.53; Cl, 7.03.

Compound 34

mp 235° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.35-0.76 (4H, m), 0.96-1.14 (1H, m), 1.16-1.42 (2H, m), 1.43-1.82 (3H, m), 1.96-2.20 (1H, m), 2.58-2.77 (1H, m), 2.78-3.07 (6H, m), 3.20-3.35 (2H, m), 3.79 (0.2H, m), 3.96 (0.8H, m), 4.35 (0.2H, m), 4.58 (0.2H, m), 4.87 (0.8H, m), 5.01 (0.8H, m), 5.95 (0.2H, br s), 6.38 (0.8H, br s), 6.59 (1H, d, J=7.3 Hz), 6.73 (1H, d, J=7.3 Hz), 7.40-7.50 (5H, m), 8.63 (0.2H, br s), 8.88 (0.8H, br s), 9.31 (0.8H, br s), 9.38 (0.2H, br s).

IR (KBr)

υ 3270, 3072, 1613, 1506, 1475, 1321, 1120, 1069, 905, 806, 710 cm⁻¹

Mass (FAB)

m/z 461 ((M+H) +).

Elementary Analysis: As C₂₈H₃₂N₂O₄.HCl.0.7H₂O

Calcd.: C, 65.99; H, 6.80; N, 5.49; Cl, 6.96.

Found.: C, 65.97; H, 6.86; N, 5.55; Cl, 6.94.

Compound 35

mp 235° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.01-1.09 (2H, m), 1.36 (1H, m), 1.50-1.64 (2H, m), 1.80-1.98 (3H, m), 2.34-2.46 (3H, m), 2.60-2.75 (3H, m), 2.80 (0.6H, s), 2.85 (2.4H, s), 2.88-3.14 (3H, m), 3.22-3.35 (2H, m), 3.90 (1H, m), 4.41 (0.2H, m), 4.61 (0.8H, d, J=3.9 Hz), 4.68 (0.2H, m), 4.97 (0.8H, m), 6.24 (0.8H, br s), 6.46 (0.2H, br s), 6.58 (1H, d, J=8.1 Hz), 6.75 (1H, m), 7.16-7.26 (3H, m), 7.30 (2H, m), 8.82 (1H, br s), 9.30 (0.8H, s), 9.33 (0.2H, s).

IR (KBr)

υ 3068, 1618, 1508, 1475, 1369, 1317, 1118, 1036, 919, 806, 750, 704 cm⁻¹.

Mass (FAB)

m/z 503 ((M+H)+).

Elementary Analysis: As C₃₁H₃₈N₂O₄.HCl

Calcd.: C, 69.06; H, 7.29; N, 5.19; Cl, 6.58.

Found.: C, 69.05; H, 7.43; N, 5.27; Cl, 6.43.

Compound 36

mp 225° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.01-1.20 (2H, m), 1.25-1.37 (3H, m), 1.50-1.64 (6H, m), 1.91 (1H, m), 2.33 (2H, t, J=7.1 Hz), 2.42 (1H, m), 2.58 (2H, t, J=7.5 Hz), 2.68 (1H, m), 2.78 (0.6H, s), 2.87 (2.4H, s), 2.93 (1H, m), 2.99-3.14 (2H, m), 3.24-3.35 (2H, m), 3.89 (1H, m), 4.42 (0.2H, m), 4.59 (0.8H, d, J=3.4 Hz), 4.76 (0.2H, m), 4.96 (0.8H, m), 6.22 (0.8H, s), 6.44 (0.2H, s), 6.58 (1H, d, J=7.8 Hz), 6.72 (1H, d, J=7.8 Hz), 7.16-7.23 (3H, m), 7.24-7.30 (2H, m), 8.81 (1H, br s), 9.29 (0.8H, s), 9.31 (0.2H, s).

IR (KBr)

υ 3086, 1618, 1508, 1460, 1315, 1174, 1120, 1038, 748, 700 cm⁻¹.

Mass (FAB)

m/z 531 ((M+H)+).

Elementary Analysis: As C₃₃H₄₂N₂O₄.HCl

Calcd.: C, 69.88; H, 7.64; N. 4.94; Cl, 6.25.

Found.: C, 69.70; H, 7.64; N, 4.98; Cl, 6.25.

Compound 37

mp 225° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.69 (1H, m), 1.01-1.20 (2H, m), 1.35 (1H, m), 1.50-1.64 (2H, m), 1.90 (1H, m), 2.41 (1H, m), 2.67 (1H, m), 2.70 (0.6H, s), 2.95 (2.4H, s), 2.89-3.13 (3H, m), 3.23-3.35 (2H, m), 3.80 (1.6H, s), 3.85-3.94 (1.4H, m), 4.47 (0.2H, m), 4.51 (0.2H, m), 4.63 (0.8H, d, J=3.9 Hz), 4.98 (0.8H, m), 6.20 (0.8H, s), 6.43 (0.2H, br s), 6.58 (1H, d, J=8.3 Hz), 6.72 (1H, d, J=8.3 Hz), 7.05-7.15 (3H, m), 7.35 (1H, m), 8.80 (1H, br s), 9.30 (0.2H, s), 9.31 (0.8H, s)

IR (KBr)

υ 3120, 1620, 1510, 1460, 1321, 1118, 777, 683, 518 cm⁻¹.

Mass (FAB)

m/z 493 ((M+H)+).

Elementary Analysis: As C₂₉H₃₃N₂O₄F.HCl

Calcd.: C, 65.83; H, 6.48; N, 5.29; Cl, 6.70; F, 3.59.

Found.: C, 65.69; H, 6.59; N, 5.44; Cl, 6.43; F, 3.60.

Compound 38

mp 198.0-206.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆) δ 0.10-0.30 (2H, m), 0.44-0.63 (2H, m), 0.83-0.99 (11H, m), 0.90-1.28 (1H, m), 1.28-1.39 (1H, m), 1.39-1.57 (2I1, m), 1.66-1.84 (1H, m), 2.12-2.38 (2H, m), 2.41-2.65 (2H, m), 2.65-2.80 (2H, m), 2.84 (0.6H, s), 2.95 (2.4H, s), 3.00-3.13 (1H, m), 3.20-3.34 (1H, m), 2.50-4.25 (3H, br s), 4.05 (1H, s), 4.38 (0.2H, dt J=11.2, 3.4 Hz), 4.54 (0.8H, d, J=3.4 Hz), 4.85 (2H, s), 4.76-4.96 (1H, m), 6.51 (1H, d, J=7.8 Hz), 6.64 (111, d, J=8.3 Hz), 6.86-7.02 (3H, m), 7.22-7.37 (2H, m), 8.65-9.60 (1H, br s)

IR (KBr)

υ 1601, 1562, 1497, 1460, 1321, 1236, 1120, 1067, 919, 758 cm⁻¹

Mass (FAB)

m/z 491 ((M+H)).

Elementary Analysis: As C₃₁H₃₇N₂O₈.0.8H₂O

Calcd.: C, 64.19; H, 6.70; N, 4.83

Found.: C, 64.16; H, 6.64; N, 4.89

Compound 39

mp 205-207° C.

NMR (400 MHz, DMSO-d₆)

δ 0.18-0.30 (2H, m), 0.47-0.60 (2H, m), 0.82-0.97 (4H, m), 1.13 (1H, m), 1.24-1.38 (5H, m), 1.38-1.60 (4H, m), 1.75 (1H, m), 2.20-2.40 (4H, m), 2.57 (1H, m), 2.70-2.79 (3H, m), 2.80 (0.6H, s), 2.88 (2.4H, s), 3.00-3.63 (5H, m), 4.10 (1H, s), 4.36 (0.2H, m), 4.53 (0.8H, d, J=3.4 Hz), 4.62 (0.2H, m), 4.95 (0.8H, m), 6.52 (1H, d, J=8.3 Hz), 6.63 (1H, d, J=8.3 Hz), 9.10 (1H,

IR (KBr)

υ 3230, 1609, 1460, 1317, 1122 cm⁻¹.

Mass (FAB)

m/z 455 ((M+H)+).

Elementary Analysis: As C₂₇H₃₈N₂O₄.0.5C₄H₆O₆.0.5H₂O

Calcd.: C, 64.66; H, 7.86; N, 5.20.

Found.: C, 64.54; H, 7.76; N. 5.31.

Compound 40

mp 210-212° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.25-0.35 (2H, m), 0.45-0.57 (2H, m), 0.84-0.96 (4H, m), 1.11 (1H, m), 1.21-1.35 (8H, m), 1.39-1.580 (4H, m), 1.72 (1H, m), 2.15-2.25 (2H, m), 2.27-2.35 (2H, m), 2.51 (1H, m), 2.65-2.76 (2H, m), 2.79 (0.6H, s), 2.88 (2.4H, s), 2.95-3.80 (5H, m), 4.03 (1H, s), 4.34 (0.2H, m), 4.51 (0.8H, d, J=3.4 Hz), 4.61 (0.2H, m), 4.89 (0.8H, m), 6.50 (1H, d, J=8.3 Hz), 6.62 (1H, d, J=8,3 Hz), 9.20 (1H, br s).

IR (KBr)

υ 3180, 1607, 1460, 1359, 1317, 1122 cm⁻¹.

Mass (FAB)

m/z 469 ((M+H)+).

Elementary Analysis: As C₂₈H₄₀N₂O₄.0.5C₄H₆O₆

Calcd.: C, 66.27; H, 7.97; N, 5.15.

Found.: C, 66.38; H, 8.14; N, 5.33.

Compound 41

mp 195-210° C.

NMR (400 MHz, DMSO-d₆)

δ 0.15-0.28 (2H, m), 0.47-0.60 (2H, m), 0.92 (1H, m), 1.12 (1H, m), 1.24 (1H, m), 1.40-1.55 (2H, m), 1.73 (1H, m), 2.20-2.35 (2H, m), 2.55 (1H, m), 2.60-2.92 (9H, m), 3.05 (1H, m), 3.15-3.95 (5.7H, m), 4.10 (1.7H, s), 4.32 (0.2H, m), 4.54 (0.8H, d, J=3.4 Hz), 4.61 (0.2H, m), 4.90 (0.8H, m), 6.52 (1H, d, J=8.3 Hz), 6.63 (1H, d, J=8.3 Hz), 7.33 (1H, m), 7.71 (1H, m), 8.40 (1H, m), 8.50 (1H, n), 9.08 (1.7H, br s).

IR (KBr)

υ 3220, 1607, 1460, 1311, 1120 cm⁻¹.

Mass (FAB )

m/z 490 ((M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₄.0.85C₄H₆O₆.0.3H₂O

Calcd.: C, 62.50; H, 6.59; N, 6.75.

Found.: C, 62.33; H, 6.77; N, 6.78.

Compound 42

mp 254.0-259.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 150.40 (1H, J), 0.47 (4H, m), 0.60 (2H, m), 0.69 (1H, m), 1.06 (1H, m), 1.40˜1.64 (3H, m), 1.90 (1H, m), 2.44 (1H, m), 2.69 (1H, m), 2.85 (3H, s), 2.92 (1H, m), 3.03 (1H, m), 3.09 (1H, dd, J=20.0, 6.4 Hz), 3.23˜3.38 (3H, m), 3.89 (1H, br d, J=5.4 Hz), 4.59, 4.63, 4.67 (2H, each br s), 5.13˜5.23 (2H, m), 6.23 (1H, s), 6.58 (1H, d, J=8.1 Hz), 6.71 (1H, d, J=8.1 Hz), 7.35 (1H, m), 7.39, 7.40 (4H, each s), 8.80 (1H, br s), 9.29 (1H, br s).

IR (KBr)

υ 3500, 3100, 2850, 1663, 1470, 1350, 1317, 1156, 1120, 1035 cm⁻¹.

Mass (FAB)

m/z 491 (M+H)+.

Elementary Analysis: As C₂₉H₃₅N₂O₅Cl.0.2H₂O

Calcd.: C, 65.64; H, 6.72; N, 5.28; Cl, 6.68.

Found.: C, 65.66; H, 6.71; N, 5.30; Cl, 6.70.

Compound 43

mp 198.0-206.0° C. (decorosition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.43 (1H, m), 0.43-0.57 (1H, m), 0.57-0.65 (1H, m), 0.65-0.77 (1H, m), 1.00-1.25 (2H, m), 1.38-1.70 (3H, m), 1.87-2.09 (1H, m), 2.35-2.50 (1H, m), 2.60-2.79 (1H, m), 2.89-3.18 (3H, m), 2.87 (1.4H, s), 2.90 (1.6H, s), 3.18-3.38(2H, m), 3.95 (1H, br s), 4.57-4.80 (2H, m), 5.29 (1.2H, s), 5.22-5,40 (0.8H, m), 6.35 (0.6H, brs), 6.45 (0.4H, br s), 6.59 (1H, d, J=7.8 Hz), 6.74 (1H, dd, J=8.3, 2.0 Hz), 7.60-7.74 (2H, m), 8.20-8.36 (2H, m), 8.87 (1H, br s), 9.34 (0.4H, s), 9.35 (0.6H, s)

IR (KBr)

υ 1686, 1638, 1560, 1543, 1522, 1460, 1346, 1120, 1035 cm⁻¹.

Mass (FAB)

m/z 536 ((M4H)+).

Elementary Analysis: As C₂₉H₃₄N₃O₇Cl0.3H₂O

Calcd.: C, 60.21; H, 6.20; N, 7.26; Cl, 6.13.

Found.: C, 60.29; H, 6.18; N, 7.16; Cl, 6.24.

Compound 44

mp>130° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.15-0.30 (2H, m), 0.45-0.60 (2H, m), 0.85-0.98 (1H, m), 1.05-1.20 (1H, m), 1.30-1.53 (3H, m), 1.68-1.82 (1H, m), 2.10-2.40 (2H, m), 2.45-2.90 (4H, m), 2.85 (3H, s), 3.00-3.18 (1H, m), 3.21-3.42 (1H, m), 4.11 (2H, s), 4.49-4.62 (2H, m), 5.10-5.30 (2H, m), 6.51 (1H, d, J=8.0 Hz), 6.62 (1H, d, J=8.0 Hz), 7.39-7.48 (1H, m), 7.81 (1H, d, J=7.3 Hz), 8.55 (1H, d, J=3.4 Hz), 8.62 (1H, s), 9.00 (2H, brs).

IR (KBr)

υ 3312, 1692, 1603, 1406, 1350, 1311, 1267, 1122, 1069, 1035 cm⁻¹

Mass (EI)

m/z 492 (M+H)+.

Elementary Analysis: As C₂₈H₃₃N₃O₅.C₄H₆N₆.0.3H₂O

Calcd.: C, 59.40; H. 6.17; N, 6.50.

Found.: C, 59.39; H, 6.27; N, 6.52.

Compound 45

mp 197.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.30 (2H, m), 0.44-0.63 (2H, m), 0.83-0.99 (1H, m), 1.00-1.20 (1H, m), 1.20-1.35 (1H, m), 1.35-1.57 (2H, m), 1.66-1.84 (1H, m), 2.10-2.34 (2H, m), 2.39-2.62 (2H, m), 2.62-2.79 (2H, m), 2.82 (0.6H, s), 2.99 (2.4H, s), 3.00-3.13 (1H, m), 3.20-3.34 (1H, m), 2.00-3.98 (3H, br s), 4.05 (1H, s), 3.95-4.13 (2H, m), 4.41 (0.2H, br d, J=12.2 Hz), 4.52 (0.8H, d, J=3.7 Hz), 4.80-4.90 (1H, m), 6.51 (1H, d, J=8.6 Hz), 6.63 (1H, d, J=7.9 Hz), 7.15-7.27 (1H, m), 7.27-7.38 (2H, m), 7.38-7.46 (2H, m), 8.65-9.50 (1H, br s)

IR (KBr)

υ 3430, 1618, 1508, 1460, 1400, 1120, 1036, 917, 746, 692 cm⁻¹.

Mass (FAB)

m/z 507 ((M+H)+).

Elementary Analysis: As C₃₁H₃₇N₂O₇S.0.5H₂O

Calcd.: C, 63.03; H, 6.48; N, 4.74; S, 5.43

Found.: C, 63.14; H, 6.51; N, 4.65; S, 5.33

Compound 46

mp >230° C. (decomposition)

NMR (400 MHz, CD₃OD)

δ 0.50 (2H, m), 0.73 (1H, m), 0.83 (1H, m), 0.92 (3H, t, J=6.8 Hz), 1.09 (1H, m), 1.28-1.55 (8H, m), 1.59-1.79 (4H, m), 1.93 (1H, m), 2.38-2.56 (2H, m), 2.64 (1H, m), 2.84-3.05 (2H, m), 2.93 (0.45H, s), 3.02 (2.55H, s), 3.05-3.22 (2H, m), 3.23-3.40 (2H, m), 3.98 (1H, m), 4.57 (0.15H, m), 4.76 (1H, br d, J=2.9 Hz), 5.09 (0.85H, ddd, J=13.7, 3.9, 3.9 Hz), 6.67 (0.85H, d, J=8.3 Hz), 6.68 (0.15H, d, J=8.3 Hz), 6.75 (0.85H, d, J=8.3 Hz), 6.76 (0.15H, d, J=8.3 Hz).

IR (KBr)

υ 3400, 3158, 1624, 1508, 1468, 1317, 1174, 1120, 1038, 907, 808 cm⁻¹.

Mass (FAB)

m/z 469 ((M+H)+)

Elementary Analysis: As C₂₈H₄₀N₂O₄.HCl.0.2H₂O

Calcd.: C, 66.11; H, 8.20; N, 5.51; Cl, 6.97.

Found.: C, 66.02; H, 8.07; N, 5.64; Cl, 7.02.

Compound 47

mp 169-170° C. (ethylacetate-methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.18 (2H, m), 0.44-0.56 (2H, m), 0.84-0.96 (4H, m), 1.10 (1H, m), 1.30-1.53 (5H, m), 1.53-1.62 (2H, m), 1.73 (1H, m), 2.12-2.38 (2H, m), 2.41-2.57 (2H, m), 2.63-2.75 (2H, m), 2.80 (3H, s), 3.04 (1H, d, J=18.6 Hz), 3.24 (1H, m), 3.45 (3H, br s, 3×OH), 3.95-4.15 (2H, m), 4.04 (1H, s), 4.48 (1H, m), 4.56 (1H, m), 6.50 (1H, d, J=7.8 Hz), 6.61 (1H, d, J=7.8 Hz), 9.05 (1H, br s, NH+).

IR (KBr)

υ 3366, 1678, 1613, 1462, 1406, 1350, 1317, 1176, 1122, 1069, 1035, 861, 808 cm⁻¹.

Mass (FAB)

m/z 457 ((M+H) +).

Elementary Analysis: As C₂₆H₃₆N₂O₅.0.5C₄H₆O₆.0.5H₂O

Calcd.: C, 62.21; H, 7.46; N, 5.18.

Found.: C, 62.40; H, 7.15; N, 5.23.

Compound 48

mp 200-212° C. (decomposition)

NMR (400 MHZ, DMSO-d₆)

δ 0.19 (2H, m), 0.45-0.57 (2H, m), 0.90 (1H, m), 1.03-1.18 (3H, m), 1.27 (1H, m), 1.34-1.63 (8H, m), 1.66-1.82 (4H, m), 2.16-2.56 (6H, m) 2.63-2.77 (2H, m), 2.79 (0.6H, s), 2.89 (2.4H, s), 3.03 (1H, br d, J=18.6 Hz), 3.25 (1H, m), 3.45 (3H, br s, 3×OH), 4.03 (1H, s), 4.35 (0.2H, m), 4.52 (0.8H, d, J=3.4 Hz), 4.59 (0.2H, m), 4.88 (0.8H, dt, J=14.1, 3.9 Hz), 6.50 (1H, d, J=8.3 Hz), 6.62 (0.8H, d, J=8.3 Hz), 6.63 (0.2H, d, J=8.3 Hz), 9.06 (1H, br s, NH+).

IR (KBr)

υ3316, 1719, 1603, 1462, 1408, 1361, 1321, 1172, 1122, 1071, 1038, 917, 808 cm⁻¹.

Mass (FAB)

m/z 481 ((M+H) +).

Elementary Analysis: As C₂₉H₄₀N₂O₄.0.5C₄H₆O₆.0.2H₂O

Calcd.: C, 66.57; H, 7.82; N, 5.01.

Found.: C, 66.63; H, 7.83; N, 5.06.

Compound 49

mp>132° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.20 (2H, m) ) 0.48-0.58 (2H, m), 0.9 1 (1H, M), 1.10 (1H, m), 1.22-1.54 (3H, 1), 1.73 (6H, m), 2.06-2.34 (2H, m), 2.45-2.62 (2H, m), 2.65-2.78 (2H, m), 2.81 (3H, s), 3.06 ( 2H, br d, J=18.6 Hz), 3.27 (1H, m), 3.29 (3H, br s), 3.50 (3.2H, br s, 3.1×OH +0.1×COOH), 3.52-3.59 (2H, (1), 4.06 (1.1 H, m), 4.07-4.30 (2H, m), 4.40-4.64 (2H, 4), 6.51 (0H, d, J=8.0 Hz), 6.62 (1H, d, J=8.0 Hz), 9.06 (1H, brs, NH+).

IR (KBr)

υ 3342, 1686, 1609, 1462, 1406, 1346, 1317, 1249, 1176, 1120, 1069, 1036, 924, 903, 806 cm⁻¹.

Mass (FAB)

m/z 459 ((M+H) +)

Elementary Analysis: As C₂₅H₃₄N₂O₆.0.55C₄H₆O₆.0.9H₂O

Calcd.: C, 58.62; H, 7.07; N, 5.03.

Found.: C, 58.67; H, 7.06; N, 4.91.

Compound 50

mp 260.0° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.08-0.32 (2H, m), 0.40-0.64 (2H, m), 0.80-1.00 (1H, 6), 1.00-1.38 (7H, m), 1.38-1.83 (6H, 35), 2.05-2.38 (3H, m), 2.40-2.65 (2H, m), 2.65-2.81 (3H, m), 2.83 (0.9H, s), 2.95 (2.1H, s), 2.98-3.15 (1H, m), 3.15-3.44 (1H, m), 4.47 (0.3H, m), 4.56 (0.3H, m), 4.58 (0.7H, d, J=3.4 Hz), 4.90 (0.7H, m), 3.50-6.20 (5H, br s), 6.29 (0.3H, d, J=15.1 Hz), 6.37 (0.7H, d, J=14.7 Hz), 6.51 (1H, d, J=8.3 Hz), 6.57-6.74 (2H, m)

IR (KBr)

υ 3420, 1651, 1599, 1450, 1408, 1321, 1120, 1036, 922, 441 cm⁻¹.

Mass (FAB)

m/z 493 ((M+H) +)

Elementary Analysis: As C₃₀H₄₃N₂O₈P1.1.3H₂O

Calcd.: C, 58.68; H, 7.48; N, 4.56; P, 5.04.

Found.: C, 58.60; H, 7.44; N, 4.61; P, 5.12.

Embodiments 41-44

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-isobutyl-3,4-dichlorophenylacetoamido)morphinan.hydrochloride 51 (yield: 78%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3,4-dichlorophenylacetoamido) morphinan.hydrochloride 52 (yield: 92%), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methyl-3,4-dichlorophenylacetoamido)morphinan.hydrochloride 51 (yield: 51%), and 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-ethyl-3,4-dichlorophenylacetoamido) morphinan.hydrochloride 54 (yield: 56%) were obtained by following the procedure of example 11 but using 17-cyclopropylmethyl-4,5α (5-epoxy-3,14β-dihydroxy-6α-isobutylaminomorphinan 5, 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-aminomorphinan (J. B. Jiang, R. N. Hanson, P. S. Portoghese, and A. E. Takemori, J. Med. Chem., 20, 1100 (1977).), 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10, and 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-ethylaminomorphinan 11 instead of the starting material 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4.

Compound 51

mp 185-188C

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.48 (1H, m), 0.61 (1H, m), 0.72 (4H, m), 0.88 (4H, m), 1.06 (2H, m), 1.57 (3H, m), 1.90 (2H, m), 2.42 (1H, m), 2.68 (1H, m), 3.00 (3H, m), 3.36 (2H, m), 3.45 (1H, m), 3.86 (3H, m), 4.4-5.1 (2H, m), 6.19 (0.7H, s), 6.50 (0.3H, s), 6.58 (1H, m), 6.73 (1H, d, J=7.8 Hz), 7.27 (1H, m), 7.52 (1H, d, J=4.4 Hz), 7.59 (1H, t, J=8.3 Hz), 8.82 (1H, brs), 9.26 (0.7H, s), 9.30 (0.3H, s)

IR (KBr)

υ 3370, 1620, 1510, 1468, 1120, 1035 cm⁻¹.

Mass (FAB)

m/z 585 (M+H)

Elementary Analysis: As C₃₂H₃₈N₂O₄Cl₂.HCl.0.2H₂O

Calcd.: C, 61.43; H, 6.35; N, 4.48; Cl, 17.00.

Found.: C, 61.44; H, 6.42; N, 4.45; Cl, 16.82.

Compound 52

mp 212.0-215.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.39 (1H, m), 0.47 (1H, m), 0.60 (1H, m), 0.68 (1H, m), 0.97 (1H, m), 1.05 (1H, m), 1.40 (2H, dd, J=14.7, 9.8 Hz), 1.60 (1H, d, J=10.7 Hz), 1.84 (1H, dt, J=15.1, 9.3 Hz), 2.44 (1H, dt, J=13.2, 4.9 Hz), 2.70 (1H, br q, J=12.7 Hz), 2.94 (1H, m), 3.04 (2H, dd, J=19.5, 6.8 Hz), 3.25˜3.35 (2H, m), 3.55 (2H, s), 3.89 (1H, d, J=6.8 Hz), 4.38 (1H, m), 4.59 (1H, d, J=3.4 Hz), 6.25 (1H, s), 6.56 (1H, d, J=8.3 Hz), 6.73 (1H, d, J=8.3 Hz), 7.29 (1H, dd, J=8.3, 2.0 Hz), 7.56 (1H, d, J=2.0 Hz), 7.57 (1H, d, J=8.3 Hz), 8.14 (1H, d, J=8.3 Hz), 8.83 (1H, br s), 9.28 (1H,

IR (KBr)

υ 3400, 2942, 1651, 1510, 1460, 1236, 1120, 1035, 903, 787 cm⁻¹.

Mass (FAB)

m/z 529 (M+H)+.

Elementary Analysis: As C₂₈H₃₁N₂O₄Cl₃.0.3H₂O

Calcd.: C, 58.86; H, 5.58; N, 4.90; Cl, 18.62.

Found.: C, 58.99; H, 5.79; N, 4.93; Cl, 18.61.

Compound 53

mp 194-196° C. (decomposition)

NMR (400 MHz, CDCl₃+D20, Data for free base)

δ 0.09-0.17 (2H, m), 0.49-0.57 (2H, m), 0.78-0.89 (2H, m), 1.05 (0.7H, dt, J=13.2, 3.4 Hz), 1.42-1.51 (0.3H, m), 1.49 (2H, brd, J=13.2 Hz), 1.97-2.29 (3H, m), 2.36 (2H, d, J=6.4 Hz), 2.56-2.69 (2H, m), 2.92 (2.1H, s), 2.99 (0.9H, s), 3.00-3.08 (2H, m), 3.48 (0.7H, d, J=15.6 Hz), 3.49-3.56 (1H, m), 3.66 (0.7H, d, J=15.6 Hz), 3.70 (0.6H, s), 4.55 (0.3H, d, J=8.3 Hz), 4.58 (0.7H, d, J=8.3 Hz), 6.57 (0.3H, d, J=8.3 Hz), 6.73 (0.3H, d, J=8.3 Hz), 6.78-6.82 (1.4H, m), 6.83 (0.7H, d, J=8.3 Hz), 7.11 (0.3H, dd, J=8.3, 2.5 Hz), 7.23 (0.7H, d, J=8.3 Hz), 7.36 (0.3H, d, J=2.0 Hz), 7.39 (0.3H, d, J=8.3 Hz).

IR (KBr)

υ 3420, 1620, 1321, 1127, 1035 cm⁻¹.

Mass (FAB)

m/z 543 (M+H)+.

Elementary Analysis: As C₂₉H₃₂N₂O₄Cl₂.HCl.0.7H₂O

Calcd.: C, 58.78; H, 5.85; N, 4.73; Cl, 17.95.

Found.: C, 58.72; H, 5.86; N, 4.71; Cl, 18.03.

Compound 54

mp 184-187° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.35-0.75 (4H, m), 1.00-1.53 (4H, m), 1.09 (2.25H, t, J=6.8 Hz), 1.15 (0.75H, t, J=6.8 Hz), 1.60-1.75 (1H, m), 1.93-2.10 (1H, m), 2.38-2.50 (1H, m), 2.80-2.93 (1H, m), 2.96-3.08 (2H, m), 3.15-3.35 (3H, m), 3.40-3.60 (2H, m), 3.56 (2.25H, s), 3.76 (0.75H, s), 3.76-3.87 (1H, m), 4.76 (0.75H, brd, J=7.9 Hz), 5.07 (0.25H, brd, J=7.9 Hz), 6.08 (0.25H, brs), 6.45 (0.75H, brs), 6.63 (0.25H, d, J=7.9 Hz), 6.71 (0.25H, d, J=7.9 Hz), 6.72 (0.75H, d, J=8.1 Hz), 6.80 (0.75 H, d, J=8.1 Hz), 6.98 (0.75H, dd, J=8.3, 2.0 Hz), 7.03 (0.75H, d, J=2.0 Hz), 7.24 (0.25H, dd, J=8.3, 2.0 Hz), 7.51 (0.75H, d, J=8.3 Hz), 7.53 (0.25H, d, J=2.0 Hz), 7.57 (0.25H, d, J=8.3 Hz), 8.80 (1H, brs) 9.31 (0.25H, s), 9.65 (0.75H, s).

IR (KBr)

υ 3420, 1626, 1508, 1319, 1127, 1033 cm⁻¹.

Mass (FAB)

m/z 557 (M+H)+.

Elementary Analysis: As C₃₀H₃₄N2O₄Cl₂.HCl.0.3H₂O

Calcd.: C, 60.12; H, 5.99; N, 4.67; Cl, 17.74.

Found.: C, 60.14; H, 6.17; N, 4.70; Cl, 17.70.

Examples 45-63

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylphenylacetamido)morphinan.hydrochloride 55 (yield: 57%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-60-(N-methylbenzyloxycarbamido)morphinan.hydrochloride 56 (yield: 43%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-60-(N-methyl-3-phenylpropionamido) morphinan.hydrochloride 57 (yield: 84%), 17-cyclopropylmethyl-3,4β-dihydroxy-4,5α-epoxy-6β-(N-methylphenoxyacetamido)morphinan.tartrate 58 (yield: 75%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylbutyroxycarbamido)morphinan.tartrate 5 (yield: 81%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-60-(N-methyl-3-trifluoromethylcinnaiamido)morphinan.tartrate 60 (yield: 84%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan.tartrate 61 (yield: 91%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylhexanamido)morphinan.tartrate 62 (yield: 43%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-methylcinnamamido) morphinan.tartrate 63 (yield: 88%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-cyclopentylpropionamido)morphinan.tartrate 64 (yield: 39%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylthiophenoxyacetamido)morphinan.tartrate 65 (yield: 75%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-2-naphthamido)morphinan.hydrochloride 66(yield: 95%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-2-methoxyethoxycarbamido) morphinan.tartrate 67 (yield: 63%), 17-cyclopropylmethyl-3,14,β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-cyclohexylacrylamido) morphinan.tartrate 68 (yield: 77%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-methylcinnamamido)morphinan.hydrochloride 69 (yield: 87%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-62.[N-methyl-trans-3-(2-furyl)acrylamido] morphinan.hydrochloride 70 (yield: 80%), 17-cyclopropylmethyl-3,14,β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-thienyl) acrylamido]morphinan.methanesulfonate 71 (yield: 88%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-60β (N-methyl-2-trifluoromethylcinnamamido)morphinan.hydrochloride 72 (yield: 93%), and 17-cyclopropylmethyl-3,14,β-dihydroxy-4,5α-epoxy-6β-(N-methyl-4-trifluoromethylcinnamamido) morphinan.tartrate 73 (yield: 84%) were obtained by following the procedure of example 11 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10 instead of the starting material 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4, and using phenylacetyl chloride, benzyl chloroformate, 3-phenylpropionyl chloride, phenoxyacetyl chloride, butyl chloroformate, 3-trifluoromethylcinnamoyl chloride, trans-3-(3-furyl)acryloyl chloride, hexanoyl chloride, 3-methoxycinnamoyl chloride, 3-cyclopentylpropionyl chloride, thiophenoxyacetyl chloride, 2-naphthoyl chloride, 2-methoxyethyl chloroformate, trans-3-cyclohexylacryloyl chloride, 3-methylcinnamoyl chloride, trans-3-(2-furyl)acryloyl chloride, trans-3-(3-thienyl)acryloyl chloride, 2-trifluoromethylcinnamoyl chloride and 4-trifluoromethylcinnamoyl chloride instead of 3,4-dichlorophenylacetyl chloride.

Compound 55

mp 205-207° C.

NMR (500 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.50 (1H, m), 0.57 (1H, m), 0.67 (1H, m), 0.81 (1H, m), 1.00-1.08 (2H, m), 1.37-1.56 (2H, m), 1.97 (1H, m), 2.42-2.53 (2H, m), 2.83 (3H, s), 2.85 (1H, m), 2.45-3.07 (3H, m), 3.25-3,37 (2H, m), 3.46-3.57 (2H, m), 3.81 (0.8H, m), 4.04 (0.2H, m), 4.81 (0.8H, m), 4.88 (0.2H, m), 6.31 (0.2H, br s), 6.42 (0.8H, br s), 6.63 (0.2H, d, J=8.1 Hz), 6.70 (0.2H, d, J=8.1 Hz), 6.75 (0.8H, d, J=8.1 Hz), 6.77-6.80 (1.4H, m), 6.84 (0.8H, d, J=8.1 Hz), 7.12-7.33 (3.6H, m), 8.80 (1H, br s), 9.27 (0.2H, s), 9.65 (0.8H, s).

IR (KBr)

υ 3400, 1620, 1502, 1460, 1321, 1125, 1033, 920, 859, 748, 719 cm⁻¹

Mass (FAB)

m/z 475 ((M+H)+)

Elementary Analysis: As C₂₉H₃₄N₂O₄.HCl.0.5H₂O

Calcd.: C, 66.98; H, 6.98; N, 5.38; Cl, 6.82.

Found.: C, 67.25; H, 7.05; N, 5.40; Cl, 6.43.

Compound 56

mp 189.0-192.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.47 (1H, m), 0.47-0.56 (1H, m), 0.56-0.63 (1H, m), 0.63-0.76 (1H, m), 1.00-1.14 (1H, m), 1.20-1.52 (3H, m), 1.63-1.82 (1H, m), 2.03-2.22 (1H, m), 2.34-2.59 (1H, m), 2.80-2.90 (1H, m), 2.90 (1.7H, s), 2.93 (1.3H, s), 2.98-3.17 (2H, m), 3.22-3.40 (2H, m), 3.60-3.72 (0.6H, m), 3.72-3.80 (0.4H, m), 3.84 (1H, d, J=4.9 Hz), 4.83 (1H, brt), 4.98 (0.4H, d, J=13.2 Hz), 5.04 (1H, d, J=12.7 Hz), 5.09 (0.6H, d, J=13.2 Hz), 6.42 (1H, brs), 6.72 (0.6H, d, J=8.3 Hz), 6.77 (0.4H, d, J=7.8 Hz), 7.37 (5H, s), 7.16-7.45 (2H, m), 8.83 (1H, brs), 9.32 (0.4H, s), 9.45 (0.6H, s)

IR (KBr)

υ 1678, 1560, 1543, 1460, 1315, 1152, 1033 cm⁻¹.

Mass (FAB)

m/z 491 ((M+H)+).

Elementary Analysis: As C₂₉H₃₅N₂O₅Cl

Calcd.: C, 66.09; H, 6.69; N, 5.31; Cl, 6.73

Found.: C, 66.10; H, 6.64; N, 5.18; Cl, 6.56

Compound 57

mp 207.0° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.47 (1H, m), 0,47-0.55 (1H, m), 0.55-0.63 (1H, m), 0.63-0.75 (1H, m), 0.99-1.13 (1H, m), 1.13-1.50 (3H, m), 1.60-1.78 (1H, m), 1.98-2.16 (1H, m), 2.28-2.52 (3H, m), 2.52-2.95 (4H, m), 2.83 (2.4H, s), 2.96 (0.6H, s), 2.95-3,16 (2H, m), 3.22-3.35 (2H, m), 3.36-3.53 (1H, m), 3.83 (1H, m), 4.79 (0.8H, d, J=7.8 Hz), 4.85 (0.2H, d, J=8.3 Hz), 6.38 (0.2H, m), 6.46 (0.8H, m), 6.60-6.80 (2H, m), 7.02-7.32 (5H, m), 8.82 (1H, br s), 9.29 (0.2H, s), 9.56 (0.8H, s)

IR (KBr)

υ 3416, 1622, 1502, 1454, 1410, 1383, 1321, 1125 cm⁻¹.

Mass (FAB)

m/z 489 (M+).

Elementary Analysis: As C₃₀H₃₇N₂O₄Cl₁.0.2H₂O

Calcd.: C, 67.92; H, 7.11; N, 5.28; Cl, 6.68

Found.: C, 67.96; H, 7.06; N, 5.27; Cl, 6.85

Compound 58

mp 150-200° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.21 (2H, m), 0.46-0.58 (2H, m), 0.90 (1H, m), 1.15-1.46 (3H, m), 1.57 (1H, m), 2.03-2.17 (2H, m), 2.28 (1H, m), 2.58-2.78 (3H, m), 2.82 (2.4H, s), 3.00 (0.6H, s), 3.08 (1H, d, J=18.9 Hz), 3.24 (1H, m), 3.45 (1H, m), 3.50 (3H, br s, 3×OH), 4.00-4.05 (1H, m), 4.04 (1H, s), 4.63-4.82 (3H, m), 6.54-6.67 (2H, m), 6.78-6.95 (3H, m), 7.18-7.29 (2H, m), 9.34 (1H, br s, NH+).

IR (KBr)

υ 3390, 1638, 1601, 1497, 1323, 1241, 1118, 1064, 1035, 922, 859 cm⁻¹.

Mass (FAB)

m/z 491 ((M+H)+).

Elementary Analysis: As C₂₉H₃₄N₂O₅.0.5C₄H₆O₆.1.1H₂O

Calcd.: C, 63.60; H, 6.75; N, 4.78.

Found.: C, 63.69; H, 6.63; N, 4.72.

Compound 59

mp 110-150° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

d 0.20 (2H, m), 0.45-0.56 (2H, m), 0.76-0.96 (4H, m), 1.14-1.40 (5H, m), 1.40-1.60 (3H, m), 2.01-2.15 (2H, m), 2.25 (1H, m), 2.55-2.77 (3H, m), 2.82 (3H, s), 3.06 (1H, d, J=18.6 Hz), 3.23 (1H, m), 3.53 (3H, br s, 3×OH), 3.53-3.68 (2H, m), 3.84-3.98 (2H, m), 4.01 (1H, s), 4.67 (1H, m), 6.55 (1H, d, J=8.1 Hz), 6.61 (1H, d, J=8.1 Hz), 9.10 (1H, br s, NH+).

IR (KBr)

υ 3420, 1678, 1607, 1460, 1408, 1359, 1315, 1164, 1122, 1067, 1035, 922, 861 cm⁻¹.

Mass (FAB)

m/z 457 ((M+H)+).

Elementary Analysis: As C₂₆H₃₆N₂O₅.0.5C₄H₆O₆.0.5H₂O

Calcd.: C, 62.21; H, 7.46; N, 5.18.

Found.: C, 62.21; H, 7.59; N, 5.33.

Compound 60

mp 156-159° C.

NMR (400 MHz, DMSO-d₆)

δ 0.21 (2H, m), 0.52 (2H, m), 0.91 (1H, m), 1.2-1.5 (3H, m), 1.57 (1H, d, J=13.2 Hz), 2.12 (2H, m), 2.29 (1H, m), 2.49 (1H, m), 2.6-2.8 (3H, m), 2.90 (2H, s), 3.08 (1H, d, J=18.6 Hz), 3.17 (1H, s), 3.26 (1H, m), 3.67 (0.7H, m), 4.02 (1H, s), 4.21 (0.3H, m), 4.68 (0.7H, d, J=7.8 Hz), 4.79 (0.3H, d, J=8.3 Hz), 6.6-6.8 (2.6H, m), 7.37 (1H, dd, J=7.3, 16.1 Hz), 7.5-7.8 (3.8H, m), 8.02 (0.3H, d, J=7.8 Hz), 8.14 (0.3H, s)

IR (KBr)

υ 3350, 1649, 1601, 1336, 1168, 1127 cm⁻¹.

Mass (FAB)

m/z 555 (M+H)

Elementary Analysis: As C₃₁H₃₃N₂O₄F₃.0.5(C₄H₆O₆).0.3H₂O

Calcd.: C, 62.41; H, 5.81; N, 4.41; F, 8.98

Found.: C, 62.32; H, 5.99; N, 4.48; F, 8.88

Compound 61

mp 168-172° C.

NMR (400 MHz, DMSO-d₆)

δ 0.20 (2H, brs), 0.52 (2H, m),0.90 (1H, m), 1.2-1.4 (3H, m), 1.56 (1H, d, J=13.2 Hz), 2.12 (2H, m), 2.24 (1H, m), 2.47 (1H, m), 2.5-2.8 (3H, m), 2.86 (2H, s), 3.08 (1H, d, J=19.6 Hz), 3.10 (1H, s), 3.22 (1H, m), 3.60 (0.7H, m), 4.00 (1H, s), 4.19 (0.3H, m), 4.66 (0.7H, d, J=8.3 Hz), 4.76 (0.3H, d, J=8.3 Hz), 6.39 (0.7H, d, J=15.6 Hz), 6.5-6.7 (2H, m), 6.74 (0.7H, d, J=8.3 Hz), 6.89 (0.3H, d, J=15.1 Hz), 7.00 (0.3H, s), 7.21 (0.7H, d, J=15.6 Hz), 7.36 (0.3H, d, J=15.1 Hz), 7.66 (0.7H, s), 7.72 (0.3H, s), 7.92 (0.7H, s), 8.03 (0.3H, s)

IR (KBr)

υ 3370, 1651, 1599, 1323, 1158, 1114 cm⁻¹.

Mass (FAB)

m/z 477 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₅.0.5 (C₄H₆O₆).0.2H₂O

Calcd.: C, 64.90; H, 6.43; N, 5.04.

Found.: C, 64.79; H, 6.59; N, 5.01.

Compound 62

mp 150-158° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, m), 0.48-0.59 (2H, m), 0.79 (2.1H, br t, J=6.8 Hz), 0.88 (0.9H, br t, T=6.8 Hz), 0.92 (1H, m), 1.11-1.22 (3H, m), 1.23-1.51 (6H, m), 1.58 (1H, m), 1.98-2.33 (5H, m), 2.52 (1H, m), 2.67-2.82 (3H, m), 2.77 (2.1H, s), 2.93 (0.9H, s), 3.11 (1H, br d, J=19.1 Hz), 3.33 (1H, m), 3.48 (1H, m), 3.50 (5H, br s, 5×OH), 4.08 (2H, s), 4.60 (0.7H, d, J=8.3 Hz), 4.72 (0.3H, d, J=8.3 Hz), 6.56 (0.3H, d, J=7.8 Hz), 6.60 (0.7H, d, J=7.8 Hz), 6.62 (0.3H, d, J=7.8 Hz), 6.67 (0.7H, d, J=7.8 Hz), 9.26 (1H, br s, NH+).

IR (KBr)

υ 3314, 1719, 1618, 1460, 1412, 1311, 1267, 1120, 1069, 1035, 922, 859 cm⁻¹.

Mass (FAB)

m/z 455 ((M+H)+).

Elementary Analysis: As C₂₇H₃₈N₂O₄.C₄H₆O₆.1.0H₂O

Calcd.: C, 59.79; H, 7.45; N, 4.50.

Found.: C, 59.59; H, 7.46; N, 4.67.

Compound 63

mp 160° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.15-0.35 (2H, m), 0.45-0.65 (2H, m), 0.85-1.05 (1H, m), 1.20-1.50 (3H, m), 1.52-1.70 (1H, m), 2.00-2.25 (2H, m), 2.25-2.42 (1H, m), 2.63-2.77 (3H, m), 2.90 (1.8H, s), 2.90-4.20 (3H, br s), 3.05-3.22 (1H, m), 3.15 (1.2H, s), 3.22-3.42 (1H, m), 3.50-3.74 (1.6H, m), 3.77 (1.8H, s), 3.80 (1.2H, s), 4.00 (1H, s), 4.20 (0.4H, br s), 4.71 (0.6H, d, J=7.8 Hz), 4.80 (0.4H, d, J=8.3 Hz), 6.55-6.71 (2.6H, m), 6.92 (0.6H, dd, J=8.3, 2.5 Hz), 6.95-7.03 (1H, m), 7.10 (0.6H, d, J=7.3 Hz), 7.17 (0.4H, d, J=15.1 Hz), 7.23-7.35 (2.4H, m), 7.42 (0.4H, d, J=15.6 Hz), 9.07 (0.4H, br s), 9.37 (0.6H, br s)

IR (KBr)

υ 3390, 1642, 1599, 1460, 1408, 1313, 1272, 1127, 1035, 787, 683 cm⁻¹.

Mass (FAB)

m/z 517 ((M+H)+).

Elementary Analysis: As C₃₃H₃₉N₂O₈.0.7H₂O

Calcd.: C, 65.59; H, 6.74; N, 4.64

Found.: C, 65.46; H, 6.78; N, 4.70

Compound 64

mp 145-160° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, m), 0.48-0.59 (2H, m), 0.82-1.12 (3H, m), 1.14-1.78 (13H, m), 2.00-2.33 (5H, m), 2.52 (1H, m), 2.66-2.81 (3H, m), 2.76 (2.4H, s), 2.93 (0.6H, s), 3.11 (1H, br d, J=18.6 Hz), 3.31 (1H, m), 3.46 (1H, m), 3.50 (5H, br s, 5×OH), 4.07 (2H, s), 4.61 (0.8H, d, J=7.8 Hz), 4.71 (0.2H, d, J=7.8 Hz), 6.56 (0.2H, d, J=8.0 Hz), 6.59 (0.8H, d, J=8.0 Hz), 6.61 (0.2H, d, J=8.0 Hz), 6.66 (0.8H, d, J=8.0 Hz), 9.25 (1H, br s, NH+).

IR (KBr)

υ 3398, 1721, 1620, 1456, 1408, 1325, 1243, 1125, 1071, 1035, 922, 859 cm⁻¹.

Mass (FAB)

m/z 481 ((M+H)+).

Elementary Analysis: As C₂₉H₄₀N₂O₄.C₄H₆O₆.0.3H₂O

Calcd.: C, 62.31; H, 7.38; N, 4.40.

Found.: C, 62.18; H, 7.65; N, 4.57.

Compound 65

mp 145.0° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.15-0.30 (2H, m), 0.43-0.60 (2H, m), 0.83-0.98 (1H, m), 1.13-1.26 (1H, m), 1.26-1.41 (2H, m), 1.43-1.62 (1H, m), 1.97-2.19 (2H, m), 2.19-2.33 (1H, m), 2.40-2.55 (1H, m), 2.55-2.78 (3H, m), 2.80 (2.4H, s), 3.03 (0.6H, s), 3.05 (1H, br d, J=13.4 Hz), 3.22 (1H, br s), 2.90-4.30 (3H, br s), 3.42-3.52 (1H, m), 3.74 (0.8H, d, J=14.0 Hz), 3.91 (0.8H, d, J=14.7 Hz), 3.96 (0.2H, d, J=14.6 Hz), 4.02 (0.2H, d, J=14.6 Hz), 4.04 (1H, s), 4.61 (0.8H, d, J=7.9 Hz), 4.73 (0.2H, d, J=7.9 Hz), 6.55 (0.2H, d, J=7.9 Hz), 6.59-6.67 (1H, m), 6.71 (0.8H, d, J=7.9 Hz), 7.08-7.26 (4.2H, m), 7.30 (0.4H, t), 7.35-7.42 (0.4H, m), 9.10-9.60 (1H, br s)

IR (KBr)

υ 3380, 1620, 1508, 1408, 1313, 1267, 1122, 1035, 690 cm⁻¹.

Mass (FAB)

m/z 507 ((M+H)+).

Elementary Analysis: As C_(31.4)H_(37.6)N₂O_(7.6)Sl.0.6H₂O

Calcd.: C, 62.08; H, 6.44; N, 4.61; S, 5.28.

Found.: C, 61.84; H, 6.60; N, 4.67; S, 5.35.

Compound 66

mp 220° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.34 (1H, m), 0.47 (1H, m), 0.54 (1H, m), 0.62 (1H, m), 0.87 (1H, m), 0.99 (1H, m), 1.28 (1H, m), 1.4-1.6 (2H, m), 2.17 (1H, m), 2.34 (1H, m), 2.52 (1H, m), 2.7-2.9 (2H, m), 3.01 (1H, m), 3.10 (2H, s), 3.2-3.4 (3.7H, m), 3.70 (0.7H, m), 3.87 (0.3H, m), 4.15 (0.3H, m), 5.00 (0.7H, d, J=7.8 Hz), 5.06 (0.3H, m), 6.37 (0.3H, m), 6.39 (0.7H, d, J=7.8 Hz), 6.58 (0.7H, d, J=8.3 Hz), 6.71 (0.3H, m), 7.6-8.0 (7H, m)

IR (KBr)

υ 3400, 1620, 1319, 1176, 1120, 1035 cm⁻¹.

Mass (FAB)

m/z 511 (M+H)

Elementary Analysis: As C₃₂H₃₄N₂O₄.HCl.0.4H₂O

Calcd.: C, 69.34; H, 6.51; N, 5.05; Cl, 6.40

Found.: C, 69.13; H, 6.86; N, 4.96; Cl, 6.73

Compound 67

mp>130° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, m), 0.48-0.58 (2H, m), 0.92 (1H, m), 1.23-1.38 (3H, m), 1.58 (1H, m), 2.02-2.18 (2H, m), 2.27 (1H, m), 2.52 (1H, m), 2.66-2.79 (3H, m), 2.81-2.87 (3H, m), 3.08 (1H, br d, J=18.6 Hz), 3.14 (1.5H, br s), 3,28 (1.5H, br s), 3.30 (1H, m), 3.42-3.57 (2H, m), 3.50 (4H, br s, 3.5×OH+0.5×COOH), 3.61 (1H, m), 4.02-4.13 (2H, m), 4.05 (1.5H, s), 4.69 (1H, m), 6.56 (1H, d, J=8.3 Hz), 6.63 (1H, m), 9.15 (1H, br s, NH+).

IR (KBr)

υ 3424, 1686, 1609, 1460, 1410, 1313, 1251, 1123, 1066, 1033, 922, 905, 859 cm⁻¹.

Mass (FAB)

m/z 459 ((M+H)+).

Elementary Analysis: As C₂₅H₃₄N₂O₆.0.75C₄H₆O₆.0.8H₂O

Calcd.: C, 57.44; H, 6.90; N, 4.78.

Found.: C, 57.41; H, 6.89; N, 4.71.

Compound 68

mp 154.0° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.16-0.32 (2H, m), 0.42-0.62 (2H, m), 0.82-1.02 (2H, m), 1.02-1.42 (7H, m), 1.42-1.80 (6H, m), 1.88-2.33 (4H, m), 2.42-2.58 (1H, m), 2.58-2.87 (3H, m), 2.60-5.10 (3H, br s), 2.81 (2.1H, s), 3.01 (0.9H, s), 3.09 (1H, br d, J=18.3 Hz), 3.28 (1H, br s), 3.60 (0.7H, m), 4.05 (1H, s), 4.11 (0.3H, m), 4.61 (0.7H, d, J=7.9 Hz), 4.73 (0.3H, d, J=8.5 Hz), 5.93 (0.7H, d, J=15.3 Hz), 6.33 (0.7H, d, J=15.3 Hz), 6.34 (0.3H, d, J=15.3 Hz), 6.52-6.62 (1.6H, m), 6.66 (0.7H, d, J=8.5 Hz), 8.60-9.60 (1H, br s)

IR (KBr)

υ 3322, 1651, 1601, 1504, 1450, 1410, 1311, 1267, 1216, 1129, 681 cm⁻¹.

Mass (FAB)

m/z 493 ((M+H)+).

Elementary Analysis: As C_(32.8)H_(44.2)N₂O_(8.2).0.8H₂O

Calcd.: C, 64.36; H, 7.54; N, 4.58

Found.: C, 64.37; H, 7.67; N, 4.58

Compound 69

mp 245° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.50 (1H, rm), 0.59 (1H, m), 0.69 (1H, m), 1.07 (1H, m), 1.2-1.5 (3H, m), 1.72 (1H, d, J=13.7), 2.12 (1H, m), 2.34 (3H, s), 2.4-2.6 (2H, m), 2.88 (1H, m), 2.92 (2H, s), 3.0-3.1 (2H, m), 3.18 (1H, s), 3.3-3.4 (2H, m), 3.66 (0.7H, m), 3.83 (1H, m), 4.20 (0.3H, m), 4.83 (0.7H, d, J=7.8 Hz), 4.90 (0.3H, d, J=8.3 Hz), 6.6-6.8 (2H, m), 6.85 (0.7H, d, J=8.3 Hz), 7.1-7.3 (4.4H, m), 7.41 (0.3H, d, J=15.1 HZ), 7.48 (0.3H, d, J=7.3 Hz), 7.54 (0.3H, brs)

IR (KBr)

υ 3390, 1647, 1605, 1323, 1127, 1035 cm⁻¹.

Mass (FAB)

m/z 501 (M+H)

Elementary Analysis: As C₃₁H₃₆N₂O₄.HCl.0.8H₂O

Calcd.: C, 67.51; H, 7.06; N, 5.08; Cl, 6.43.

Found.: C, 67.35; H, 7.05; N, 5.17; Cl, 6.53.

Compound 70

mp 200° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.53 (1H, m), 0.61 (1H, m), 0.69 (1H, m), 1.08 (1H, m), 1.28 (0.5H, m), 1.3-1.5 (2.5H, m), 1.74 (1H, m), 2.15 (1H, m), 2.4-2.6 (2.5H, m), 2.8-2.9 (1.5H, m), 2.93 (1.5H, s), 3.0-3.1 (2H, m), 3.16 (1.5H, s), 3.3-3.4 (2H, m), 3.61 (0.5H, m), 3.85 (1H, brs), 4.20 (0.5H, m), 4.85 (0.5H, d, J=7.3 Hz), 4.91 (0.5H, d, J=7.8 Hz), 6.4-6.7 (3.5H, m), 6.8-6.9 (1.5H, m),7.14 (0.5H, d, J=15.1 Hz), 7.28 (0.5H, d, J=15.6 Hz), 7.68 (0.5H, s), 7.80 (0.5H, s)

IR (KBr)

υ 3390, 1647, 1597, 1321, 1127, 1017 cm⁻¹.

Mass (FAB)

m/z 477 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₅.HCl.0.6H₂O

Calcd.: C, 64.20; H, 6.58; N, 5.35; Cl, 6.77.

Found.: C, 64.21; H, 6.84; N, 5.38; Cl, 6.69.

Compound 71

mp 235° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.51 (1H, m), 0.60 (1H, m), 0.68 (1H, m), 1.08 (1H, m), 1.2-1.5 (3H, m), 1.72 (1H, d, J=12.2 Hz), 2.12 (1H, m), 2.34 (3H, s), 2.4-2.5 (2H, m), 2.86 (1H, m), 2.91 (2H, s), 3.0-3.1 (2H, m), 3.15 (1H, s), 3.3-3.5 (2H, m), 3.61 (0.7H, m), 3.82 (1H, brs), 4.19 (0.3H, m), 4.81 (0.7H, d, J=7.8 Hz), 4.89 (0.3H, d, J=8.3 Hz), 6.46 (0.7H, d, J=15.6 Hz), 6.6-6.7 (1.33H, m), 6.85 (0.7H, d, J=7.8 Hz), 7.00 (0.3H, d, J=15.1 Hz), 7.26 (0.7H, d, J=4.9 Hz), 7.31 (0.7H, d, J=15.6 Hz), 7.46 (0.3H, d, J=15.1 Hz), 7.5-7.7 (2H, m), 7.87 (0.3H, s)

IR (KBr)

υ 3410, 1642, 1595, 1323, 1127, 1035, 859 cm⁻¹.

Mass (FAB)

m/z 493 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₄S.CH₃SO₃H.0.2H₂O

Calcd.: C, 58.80; H, 6.19; N, 4.73; S, 10.83

Found.: C, 58.60; H, 6.42; N, 4.72; S, 10.82

Compound 72

mp 196-199° C.

NMR (400 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0,53 (1H, m), 0.59 (1H, m)), 0.67 (1H, m), 1.09 (1H, m), 1.3-1.5 (3H, m), 1.73 (1H, d, J=13.2 Hz), 2.20 (1H, m), 2.4-2.6 (2H, m), 2.88 (1H, m)), 2.97 (2H, s), 3.0-3.1 (2H, m), 3.23 (1H, s), 3.3-3.4 (2H, m), 3.68 (0.7H, m), 3.87 (1H, brs), 4.18 (0.3H, m), 4.88 (0.7H, d, J=7.8 Hz), 4.97 (0.3H, d, J=8.3 Hz), 6.6-6.9 (2.7H, m), 7.28 (0.3H, d, J=15.1 Hz), 7.5-7.7 (1.7H, m), 7.7-7.9 (3H, m), 8.14 (0.3H, d, J=7.8 Hz)

IR (KBr)

υ 3400, 1649, 1605, 1460, 1317, 1125, 1036 cm⁻¹.

Mass (FAB)

m/z 555 (M+H)

Elementary Analysis: As C₃₁H₃₃N₂O₄F₃.1.1HCl.0.4H₂O

Calcd.: C, 61.86; H, 5.84; N, 4.65; F, 9.47; Cl, 6.48

Found.: C, 61.88; H, 5.94; N, 4.67; F, 9.47; Cl, 6.44

Compound 73

mp 167-170° C.

NMR (400 MHz, DMSO-d₆)

δ 0.21 (2H, m), 0.52 (2H, m),0.91 (1H, m), 1.2-1.4 (3H, m), 1.58 (1H, m), 2.1-2.2 (2H, m), 2.30 (1H, m), 2.49 (1H, m), 2.6-2.8 (3H, m), 2.90 (2H, s), 3.18 (1H, d, J=18.6 Hz), 3.16 (1H, s), 3.24 (1H, m), 3.65 (0.7H, m), 4.03 (1H, s), 4.20 (0.3H, m), 4.68 (0.7H, d, J=8.3 Hz), 4.79 (0.3H, d, J=7.8 Hz), 6.5-6.7 (1.3H, m), 6.8-6.9 (1.4H, m), 7.34 (1H, d, J=15.6 Hz), 7.51 (0.3H, d, J=15.6 Hz), 7.7-7.8 (3.7H, m), 7.94 (0.3H, d, J=8.3 Hz)

IR (KBr)

υ 3400, 1649, 1601, 1325, 1168, 1114 cm⁻¹.

Mass (FAB)

m/z 555 (M+H)

Elementary Analysis: As C₃₁H₃₃N₂O₄F₃.0.5 (C₄H₆O₆).0.3H₂O

Calcd.: C, 62.41; H, 5.81; N, 4.41; F, 8.98

Found.: C, 62.36; H, 5.80; N, 4.41; F, 8.98

Example 64

17- cyclopropylmethyl-14β-hydroxy-4,5α-epoxy-6α-(N-methylbenzyloxycarbamido)morphinan-phosphate 74 (yield: 82%) was obtained by following the procedure of example 11 but using 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-methylaminomorphinan 6 instead of the starting material 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4, and using benzyl chloroformate instead of 3,4-dichlorophenylacetyl chloride.

mp 122-125° C.

NMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, m), 0.54 (2H, m), 0.93 (1H, m), 1.06 (1H, m), 1.3-1.5 (3H, m), 1.75 (1H, m), 2.2-2.3 (2H, m), 2.5-2.7 (2H, m), 2.80 (3H, s), 2.7-2.9 (2H, m), 3.18 (1H, d, J=19.5 Hz), 3.35 (1H, m), 4.59 (2H, m), 5.1-5.2 (2H, m), 6.60 (1H, d, J=7.3 Hz), 6.70 (1H, d, J=7.3 Hz), 7.10 (1H, t, J=7.3 Hz), 7.3-7.4 (5H, m)

IR (KBr)

υ 3400, 1692, 1462, 1350, 1245, 1120 cm⁻¹.

Mass (FAB)

m/z 474 (M+H)

Elementary Analysis: As C₂₉H₃₄N₂O₄.H₃PO₄.0.7H₂O

Calcd.: C, 59.52; H, 6.61; N, 4.78; P, 5.29

Found.: C, 59.51; H, 6.56; N, 4.78; P, 5.60

Example 65

17-Cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido] morphinan 75

540 mg of 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methylamino)morphinan 14 and 0.31 ml of triethylamine was dissolved in 10 ml of chloroform followed by addition of 250 mg of trans-3-(3-furyl)acryloyl chloride and stirring for 30 minutes at room temperature. The resulting solution was neutralized by addition of saturated aqueous sodium bicarbonate followed by extraction with chloroform. The organic layer was washed with saturated brine, dried and concentrated. The resulting residue was separated and purified by column chromatography [silica gel; chloroform=chloroform:methanol (100:1)] to obtain 610 mg of crude crystal. This was then recrystallized from dichloromethane-ether to obtain 580 mg of the target compound (yield: 81%).

mp 199-201° C.

NMR (400 MHz, CDCl₃)

δ 0.19 (2H, m) 0.60 (2H, m), 0.93 (1H, m), 1.58 (1H, m), 1.74 (1H, m), 2.27-2.64 (4H, m), 2.78 (1H, m), 3.00 (3H, s), 3.09 (1H, d, J=18.6 Hz), 3.40 (1H, m), 3.82 (3H, s), 4.97 (1H, br s, OH), 5.14 (1H, d, J=6.8 Hz), 5.70-5.77 (2H, m), 5.83 (1H, m), 6.56 (1H, d, J=8.3 Hz), 6.61 (1H, d, J=1.5 Hz), 6.66 (1H, d, J=15.3 Hz), 6.67 (1H, d, J=8.3 Hz), 7.42 (1H, br s), 7.63 (1H, d, J=15.3 Hz), 7.65 (1H, br s).

IR (KBr)

υ 3338, 1659, 1638, 1404, 1282, 1205, 1160, 1122, 1054, 1017, 980, 808 cm⁻¹.

Mass (EI)

m/z 488 (M+).

Example 66

17-Cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-3,14β-dihydroxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido] morphinan.hydrochloride 76

300 mg of 17-cyclopropylmethyl-7,8-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido] morphinan 75 was dissolved in 5 ml of anhydrous dichloromethane and cooled to 0° C. 3.7 ml of a dichloromethane solution of boron tribromide (1.0 M) was then added followed by stirring for 2 hours (at room temperature.). The reaction solution was cooled to 0° C. followed by addition of 6 ml of 28% aqueous ammonia:water (1:4). After stirring for 30 minutes at 0° C., the reaction solution was extracted with chloroform and methanol (3:1). The organic layer was washed with saturated brine, dried and concentrated, and the resulting residue was purified with column chromatography [silica gel; chloroform˜chloroform:methanol:28% aqueous ammonia (100:2:0.2)] to obtain 350 mg of crude crystal. This was then recrystallized from dichloromethane, methanol and ethyl acetate to obtain 265 mg of a free base of the target compound. 238 mg of the resulting crystal was dissolved in 5 ml of methanol and concentrated after adding of an excess amount of methanol solution of hydrochloride. The residue was recrystallized from methanol to obtain 159.3 mg of the target compound (yield: 57%).

mp 251° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.43 (1H, m), 0.53 (1H, m), 0.62 (1H, m), 0.72 (1H, m), 1.07 (1H, m), 1.69-1.82 (1H, m), 2.54-3.02 (4H, m), 2.91 (3H, s), 3.08-3.18 (1H, m), 3.30-3.44 (2H, m), 4.07 (0.3H, m), 4.12 (0.7H, m), 4.94 (0.7H, d, J=6.8 Hz), 5.21 (0.3H, d, J=7.3 Hz), 5.49 (0.7H, m), 5.76 (0.3H, m), 5.83-5.94 (2H, m), 6.52-6.57 (1H, m), 6.69-6.76 (1.6H, m), 6.95 (0.7H, d, J=15.3 Hz), 7.05 (0.7H, d, J=2.0 Hz), 7.31 (0.3H, br s, OH), 7.46 (0.7H, br s, OH), 7.51 (1H, d, J=15.3 Hz), 7.70 (0.3H, br s), 7.74 (0.7H, br s), 8.09 (1H, br s), 8.90-9.06 (1H, m, NH+), 9.33 (0.3H, br s, OH), 9.34 (0.7H, br s, OH).

IR (KBr)

υ 3422, 3190, 1653, 1600, 1504, 1473, 1406, 1321, 1160, 1118, 1023, 949, 870, 799 cm⁻¹.

Mass (FAB)

m/z 475 ((M+H)+).

Elementary Analysis: As C₂₈H₃₀N₂O₅.HCl

Calcd.: C, 65.81; H, 6.11; Cl, 6.94; N, 5.48.

Found.: C, 65.62; H, 6.19; Cl, 6.82; N, 5.61.

Example 67

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-5β-methyl-6α-[trans-3-(3-furyl)acrylamido]morphinan.0.5 tartrate 77 (yield: 40%) was obtained by following the procedure of example 11 but using 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-5β-methyl-6α-aminomorphinan 19 instead of the starting material of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4, and using trans-3-(3-furyl)acryloyl chloride instead of 3,4-dichlorophenylacetyl chloride.

mp >170° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.31 (2H, m), 0.53 (2H, m), 0.81-0.97 (2H, m), 1.33-1.52 (3H, m), 1.39 (3H, s), 1.70 (1H, m), 2.21-2.33 (2H, m), 2.41-2.83 (4H, m), 3.06 (1H, br d, J=18.6 Hz), 3.25 (1H, m), 3.48 (3H, br s, 30H), 4.03 (1H, s), 4.27 (1H, m), 6.49 (1H, d, J=8.3 Hz), 6.54 (1H, d, J=15.6 Hz), 6.61 (1H, d, J=8.3 Hz), 6.71 (1H, d, J=1.5 Hz), 7.34 (1H, d, J=15.3 Hz), 7.46 (1H, d, J=9.3 Hz), 7.73 (1H, br s), 8.01 (1H, s), 8.85 (1H, br s, NH+).

IR (KBr)

υ 3398, 1665, 1611, 1508, 1462, 1352, 1245, 1158, 1123, 1062, 870, 803 cm⁻¹.

Mass (FAB)

m/z 477 ((M+H)+).

Elementary Analysis: As C₂₈H₃₂N₂O₅.0.5C₄H₆O₆.1.0H₂O

Calcd.: C, 63.26; H, 6.55; N, 4.92.

Found.: C, 63.33; H, 6.43; N, 4.79.

Example 68

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan.hydrochloride 78

21.12 g (0.0404 mol) of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylamino)morphinan.phthalate 10 was dissolved in 110 ml of water. After adding 110 ml of THF and 8.75 g (0.0808 mol) of sodium carbonate, the atmosphere of reaction system was replaced to argon. Then, 6.96 g of trans-3-(3-furyl)acryloyl chloride (0.04444 mol) was dissolved in 40 ml of THF and added dropwise. After stirring for 30 minutes, 40 ml of methanol and 54 ml of 3 N aqueous sodium hydroxide were added and stirred for 1 hour. 350 ml of ethyl acetate and 250 ml of saturated aqueous sodium bicarbonate were added to the reaction solution to separate, and the aqueous layer was re-extracted with 100 ml of ethyl acetate. After washing with 200 ml of saturated brine, the resulting organic layer was dried with sodium sulfate and concentrated. The residue was dissolved in 630 ml of ethyl acetate while heating, and after dissolving, 150 ml was distilled off while heating. The resulting solution was allowed to stand and recrystallized to obtain 15.47 g of the free base of the target compound. 9.03 g of this free base was suspended in 90 ml of ethanol. After then adding 18.7 ml of 1 N aqueous hydrochloric acid, the resulting solution was concentrated and dried to obtain 9.72 g of the target compound (yield: 80%).

mp 187° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.51 (1H, m), 0.60 (1H, m), 0.68 (1H, m), 1.07 (1H, m), 1.26 (0.4H, m), 1.32-1.50 (3.6H, m), 1.73 (1H, br d, J=13.7 Hz), 2.13 (1H, m), 2.40-2.60 (3H, m), 2.88 (1H, m), 2.92 (1.8H, s), 3.06 (1H, br d, J=13.18 Hz), 3.16 (1.2H, s), 3.59 (0.6H, m), 3.86 (1H, m), 4.19 (0.4H, m), 4.86 (0.6H, d, J=7.8 Hz), 4.92 (0.4H, d, J=7.8 Hz), 6.35 (0.6H, d, J=15.6 Hz), 6.40 (0.4H, br s), 6.50 (0.6H, br s), 6.62 (0.6H, s), 6.64 (0.4H, d, J=8.3 Hz), 6.71 (1H, d, J=8.3 Hz), 6.85 (0.6H, d, J=8.3 Hz), 6.90 (0.4H, d, J=15.1 Hz), 6.99 (0.4H, s), 7.22 (0.6H, d, J=15.6 Hz), 7.36 (0.4H, d, J=15.1 Hz), 7.66 (0.6H, s), 7.72 (0.4H, s), 7.92 (0.6H, s), 8.03 (0.4H, s), 8.85 (1H, br s), 9.28 (0.4H, s), 9.68 (0.6H, s)

IR (KBr)

υ 3376, 1653, 1506, 1599, 1410, 1323, 1158, 1127, 1033, 872, 799 cm⁻¹.

Mass (FAB)

m/z 477 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₅.HCl.0.2H₂O

Calcd.: C, 65.10; H, 6.52; N, 5.42; Cl, 6.86.

Found.: C, 65.11; H, 6.63; N, 5.60; Cl, 6.80.

Examples 69-71

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[trans-3-(3-furyl)acrylamido]morphinan.hydrochloride 79, 17-cyclopropylmethyl-3-hydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan.hydrochloride 80, and 17-cyclopropylmethyl-3-hydroxy-4,5α-epoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan.hydrochloride 81 were obtained by following the procedure of example 68 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-aminomorphinan (J. B. Jiang, R. N. Hanson, P. S. Portoghese and A. E. Takemori, J. Med. Chem., 20, 1100 (1977)), 17-cyclopropylmethyl-3-hydroxy-4,5α-epoxy-6β-methylaminomorphinan 20, and 17-cyclopropylmethyl-3-hydroxy-4,5α-epoxy-6α-methylaminomorphinan 21 instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-(N-methylamino)morphinan 10.phthalate.

Compound 79

mp 240° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0.52 (1H, m), 0.59 (1H, m), 0.67 (1H, m),.1.07 (1H, m), 1.32-1.49 (2H, m), 1.57 (1H, m), 1.68-1.83 (2H, m), 2.37-2.47 (2H, m), 2.86 (1H, m), 2.98-3.12 (2H, m), 3.27-3.39 (2H, m), 3.52 (1H, m), 3.86 (1H, br d, J=4.9 Hz), 4.60 (1H, d, J=7.8 Hz), 6.23 (1H, br s), 6.33 (1H, d, J=15.6 Hz), 6.65 (1H, d, J=7.8 Hz), 6.72 (1H, d, J=7.8 Hz), 6.73 (1H, br s), 7.32 (1H, d, J=15.6 Hz), 7.74 (1H, br s), 8.01 (1H, s), 8.40 (1H, d, J=7.8 Hz), 8.86 (1H, m, NH+), 9.36 (1H, s, OH).

IR (KBr)

υ 3376, 3244, 1663, 1620, 1560, 1508, 1460, 1377, 1340, 1241, 1156, 1127, 1035, 980, 872, 795 cm⁻¹.

Mass (FAB)

m/z 463 ((M+H)+).

Elementary Analysis: As C₂₇H₃₀N₂O₅.HCl.0.2H₂O

Calcd.: C, 64.52; H, 6.30; Cl, 7.05; N, 5.57

Found.: C, 64.50; H, 6.39; Cl, 7.00; N, 5.53

Compound 8

mp 225-230° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.38 (1H, m), 0.51 (1H, m), 0.63 (2H, m), 0.97 (1H, m), 1.21 (1H, m), 1.40-1.72 (3.8H, m), 2.29 (1H, m), 2.40-2.52 (1.2H, m), 2.57 (0.2H, m), 2.70 (0.8H, m), 2.80-2.96 (1.2H, m), 2.89 (2.4H, s), 3.00-3.18 (1.6H, m), 3.14 (0.6H, s), 3.18-3.35 (2.2H, m), 3.48 (0.8H, m), 3.95-4.10 (1.2H, m), 4.65-4.95 (1H, m), 6.27-8.32 (7H, m)

IR (KBr)

υ 3370, 1651, 1593, 1321, 1156, 872 cm⁻¹.

Mass (FAB)

m/z 461 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₄.1.7HCl.0.5H₂O

Calcd.: C, 63.27; H, 6.58; N, 5.27; Cl, 11.34

Found.: C, 63.24; H, 6.60; N, 5.09; Cl, 11.55

Compound 81

mp 210-215° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.38 (1H, m), 0.48 (1H, m), 0.65 (2H, m), 0.98 (1H, m), 1.16 (2H, m), 1.32 (1H, m), 1.62-1.90 (2H, m), 2.23 (1H, m), 2.68 (0.7H, m), 2.8-3.4 (7.2H, m), 3.04 (2.1H, s), 4.01-4.10 (1H, m), 4.52 -4.81 (2H, m), 6.6-8.3 (7H, m)

IR (KBr)

υ 3380, 1651, 1591, 1323, 1160, 872 cm⁻¹.

Mass (FAB)

m/z 461 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₄.1.4HCl.0.5H₂O

Calcd.: C, 64.60; H, 6.66; N, 5.38; Cl, 9.53

Found.: C, 64.78; H, 6.82; N, 5.01; Cl, 9.29

Example 72

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(2-thienyl)acrylamido]morphinan.tartrate 82 (yield: 84%) was obtained by following the procedure of example 68 but using trans-3-(2-thienyl)acryloyl chloride instead of trans-3-(3-furyl)acryloyl chloride.

mp 178-181° C.

NMR (400 MHz, DMSO-d₆)

δ 0.22 (2H, brs), 0.53 (2H, m), 0.91 (1H, m), 1.2-1.4 (3H, m), 1.58 (1H, d, J=10.4 Hz), 2.14 (2H, m), 2.27 (1H, m), 2.50 (1H, m), 2.6-2.8 (3H, m), 2.88 (1.8H, s), 3.08 (1H, d, J=17.1 Hz), 3.11 (1.2H, s), 3.24 (1H, m), 3.59 (0.6H, m), 4.02 (1H, s), 4.20 (0.4H, m), 4.66 (0.6H, d, J=8.6 Hz), 4.76 (0.4H, d, J=8.6 Hz), 6.42 (0.6H, d, J=15.3 Hz), 6.48 (0.4H, d, J=12.2 Hz), 6.57 (1H, d, J=7.9 Hz), 6.75 (0.6H, d, J=7.9 Hz), 6.85 (0.4H, d, J=15.3 Hz), 7.07 (0.6H, t, J=3.7 Hz), 7.12 (0.4H, t, J=4.9 Hz), 7.32 (0.6H, d, J=3.1 Hz), 7.45-7.48 (1H, m), 7.58-7.67 (1.4H, m)

IR (KBr)

υ 3350, 1636, 1590, 1460, 1035 cm⁻¹.

Mass (FAB)

m/z 493 (M+H)

Elementary Analysis: As C₂₈H₃₂N₂O₄S.0.5(C₄H₆O₆).0.5H₂O

Calcd.: C, 62.48; H, 6.29; N, 4.86; S, 5.56

Found.: C, 62.32; H, 6.36; N, 4.92; S, 5.57

Example 73

17-Cyclopropylmethyl-3,14-β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-nitrophenylacetamido)morphinan.hydrochloride 83

567.1 mg (1.59 nmol) of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-methylaminomorphinan 4 and 577.9 mg (3.19 mmol) of 3-nitrophenylacetic acid were dissolved in 18 ml of chloroform followed by the addition of 657.0 mg (3.18 mmol) of dicyclohexylcarbodiimide and 10.0 mg (0.082 mmol) of 4-(N,N-dimethylamino)pyridine to this solution and stirring for 1 hour at room temperature. The solid that formed in the reaction solution was filtered out, the residue was washed with chloroform, and the filtrate and washing were combined and concentrated. The resulting solid was dissolved in a mixed solution of methanol and chloroform (4:1) followed by the addition of 445 mg (3.22 mmol) of potassium carbonate and stirring for 2 hours at room temperature. 15 ml of water was added to the reaction solution followed by extraction with chloroform (3×15 ml). The organic layers were then combined and concentrated to obtain 2.27 g of solid. This solid was then purified with column chromatography [silica gel 80 g; chloroform-methanol (40:1→20:1)] to obtain 717.4 mg of the free base of the target compound (yield: 87%). This crystal was then dissolved in methanol followed by addition of methanol solution saturated with hydrogen chloride gas. The precipitated crystal was then filtered to obtain 300.5 mg of the target compound (yield: 34%). In addition, the crystal resulting from concentration of this filtrate was then recrystallized from methanol to further obtain 354.0 mg of the target compound (yield: 40%). Both of these compounds were then combined to obtain 654.5 mg of the target compound (yield: 74%).

mp >210° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.39 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.06 (1H, m), 1.17 (1H, m), 1.37 (1H, m), 1.50-1.64 (2H, m), 1.94 (1H, m), 2.43 (1H, m), 2.68 (1H, m), 2.82 (0.6H, s), 2.90-3.14 (3H, m), 3.00 (2.4H, s), 3.22-3.38 (2H, m), 3.90-4.10 (3H, m), 4.54 (0.2H, m), 4.63 (0.8H, d, J=3.3 Hz), 4.82 (0.2H, m), 4.98 (0.8H, m), 6.28 (1H, br s, OH), 6.58 (1H, d, J=7.8 Hz), 6.75 (1H, d, J=7.8 Hz), 7.62 (0.8H, dd, J=7.8, 7.8 Hz), 7.65 (0.2H, dd, J=7.8, 7.8 Hz), 7.71 (0.8H, d, J=7.8 Hz), 7.75 (0.2H, d, J=7.8 Hz), 8.13 (1H, d, J=7.8 Hz), 8.14 (1H, br s), 8.84 (1H, m, NH+), 9.36 (1H, s, OH).

IR (KBr)

υ 3388, 1618, 1528, 1466, 1352, 1321, 1120, 1036, 920, 806 cm⁻¹.

Mass (FAB)

m/z 520 ((M+H)+).

Elementary Analysis: As C₂₉H₃₃N₃O₆.HCl

Calcd.: C, 62.64; H, 6.16; N, 7.56; Cl, 6.38.

Found.: C, 62.25; H, 6.39; N, 7.68; Cl, 6.20.

Examples 74-88

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-phenylpropiolamido)morphinan.hydrochloride 84 (yield: 16%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylcyclohexylacetamido)morphinan.hydrochloride 85 (yield: 55%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-dichlorocinnamamido) morphinan.hydrochloride 86 (yield: 78%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-nitrophenylacetamido)morphinan.hydrochloride 87 (yield: 83%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-2-bromophenylacetamido)morphinan.hydrochloride 88 (yield: 81%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[N-methyl-trans-3-(3-furyl)acrylamido]morphinane.tartrate 89 (yield: 39%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-pyridylacetamido) morphinan.2 hydrochloride 90 (yield: 83%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[N-methyl-trans-3-(3-thienyl)acrylamido]morphinan.tartrate 91 (yield: 40%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-2-pyridylacetamido)morphinan.2 hydrochloride 92 (yield: 82%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-pyridylacetamido) morphinan.hydrochloride 93 (yield: 92%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-cyclohexylpropionamido)morphinan.hydrochloride 94 (yield: 45%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-trans-2-hexenamido)morphinan.tartrate 9 (yield: 46%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-fluorocinnamamido)morphinan.tartrate 96 (yield: 79%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-nitrocinnamamido)morphinanphosphate 97 (yield: 40%) and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methylbenzoylacetamido)morphinan.tartrate 98 (yield: 37%) were obtained by following the procedure of example 73 but using phenylpropiolic acid, cyclohexylacetic acid, trans-3,4-dichlorocinnamic acid, 4-nitrophenylacetic acid, 2-bromophenylacetic acid, trans-3-(3-furyl)acrylic acid, 4-pyridylacetic acid, trans-3-(3-thienyl)acrylic acid, 2-pyridylacetic acid, 3-pyridylacetic acid, 3-cyclohexylpropionic acid, trans-2-hexenoic acid, 3-fluorocinnamic acid, 3-nitrocinnamic acid and benzoylacetic acid instead of 3-nitrophenylacetic acid.

Compound 84

mp 206.0-209.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0.49 (1H, m), 0.62 (1H, m), 0.69 (1H, m), 1.08 (1H, m), 1.19 (0.5H, m), 1.27 (0.5H, m), 1.45˜1.72 (3H, m), 1.95 (0.5H, m) 2.02 (0.5H, m), 2.48 (1H, m), 2.71 (1H, m), 2.92 (1.5H, s), 2.94˜3.06 (2H, m), 3.12 (1H, dd, J=19.5, 6.7 Hz), 3.24 (1.5H, s), 3.27˜3,38 (2H, m), 3.95 (1H, dd, J=15.6, 6.7 Hz), 4.71 (0.5H, d, J=3.7 Hz), 4.81 (0.5H, d, J=3.7 Hz), 4.92 (0.5H, br d, J=13.4 Hz), 5.09 (0.5H, br d, J=13.4 Hz), 6.32 (0.5H, s), 6.42 (0.5H, s), 6.61 (0.5H, d, J=7.9 Hz), 6.62 (0.5H, d, J=7.9 Hz), 6.74 (0.5H, d, J=7.9 Hz), 6.75 (0.5H, d, J=7.9 Hz), 7.49 (1H, t, J=7.3 Hz), 7.52˜7.57 (2H, m), 7.66 (1H, d, J=8.5 Hz), 7.72 (1H, d, J=7.3 Hz), 8.85 (0.5H, br s), 8.93 (0.5H, br s), 9.37 (1H, s)

IR (KBr)

υ 3400, 2952, 2216, 1613, 1493, 1377, 1321, 1120, 1036, 692 cm⁻¹.

Mass (FAB)

m/z 485 (M+H)+.

Elementary Analysis: As C₃₀H₃₂N₂O₄.1.5HCl.0.8H₂O

Calcd.: C, 66.61; H, 6.48; N, 5.18; Cl, 7.54.

Found.: C, 66.42; H, 6.55; N, 5.19; Cl, 7.72.

Compound 85

mp 245.0-248.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 0.93˜1.35 (8H, m), 1.53˜1.74 (8H, m), 1.90 (1H, m), 2.22 (2H, dd, J=6.8, 2.4 Hz), 2.39˜2.54 (2H, m), 2.69 (1H, m), 2.79 (0.6H, s) 2.88 (2.4H, s), 2.92 (1H, m), 3.03 (1H, br d, J=13.2 Hz), 3.09 (1H, dd, J=20.4, 7.6 Hz), 3.39 (1H, m), 3.87 (1H, d, J=6.4 Hz), 4.48 (0.2H, m), 4.60 (0.8H, d, J=3.9 Hz), 4.73 (0.2H, br s), 4.98 (0.8H, dt, J=14.2, 3.9 Hz), 6.16 (0.8H, s), 6.38 (0.2H, s), 6.58 (0.8H, d, J=8.3 Hz), 6.59 (0.2H, d, J=7.8 Hz), 6.71 (0.8H, d, J=7.8 Hz), 6.72 (0.2H, d, J=8.3 Hz), 8.79 (1H, br s), 9.28 (0.8H, s), 9.31 (0.2H, s).

IR (KBr)

3400, 2928, 2856, 1615, 1508, 1317, 1120, 804 cm⁻¹.

Mass (FAB)

m/z 481 (M+H)+.

Elementary Analysis: As C₂₉H₄₁N₂O₄Cl.0.4H₂O

Calcd.: C, 66.43; H, 8.04; N, 5.34; Cl, 6.76.

Found.: C, 66.33; H, 7.81; N, 5.35; Cl, 6.97.

Compound 86

mp 249-258° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.43 (1H, m), 0.43-0.54 (1H, m), 0.54-0.66 (1H, m), 0.66-0.76 (1H, m), 0.99-1.12 (1H, m), 1.12-1.33 (1H, m), 1.33-1.50 (1H, m), 1.50-1.70 (2H, m), 1.86-2.03 (1H, m), 2.40-2.50 (1H, m), 2.61-2.78 (1H, m), 2.87-2.99 (1H, m), 2.90 (0.6H, s), 2.99-3.19 (2H, m), 3.09 (2.4H, s), 3.19-3.39 (2H, m), 3.92 (1H, br d, J=5.9 Hz), 4.63 (0.2H, m), 4.73 (0.8H, d, J=3.9 Hz), 4.92 (0.2H, brs), 5.04 (0.8H, dt, J=14.2, 4.0 Hz), 6.27 (0.8H, br s), 6.46 (0.2H, br s), 6.60 (1H, d, J=7.8 Hz), 6.73 (1H, d, J=7.8 Hz), 7.32 (0.2H, d, J=15.1 Hz), 7.38 (0.8H, d, J=15.1 Hz), 7.47 (0.2H, d, J=15.1 Hz), 7.49 (0.8H, d, J=15.1 Hz), 7.64-7.73 (1H, m), 7.75 (1H, dd, J=8.3, 2.0 Hz), 8.04 (0.2H, s), 8.13 (0.8H, d, J=2.0 Hz), 8.82 (1H, br s), 9.31 (0.8H, s), 9.34 (0.2H, s),

IR (KBr)

υ 1649, 1599, 1510, 1475, 1377, 1317, 1120, 1033 cm⁻¹.

Mass (FAB)

m/z 555 ((M+H)+).

Elementary Analysis: As C₃₀H₃₃N₂O₄Cl₃

Calcd.: C, 60.87; H, 5.62; N, 4.73; Cl, 17.97

Found.: C, 60.87; H, 5.82; N, 4.73; Cl, 17.75

Compound 87

mp >190° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

d 0.39 (1H, m), 0.47 (1H, m), 0.61 (1H, m),0.68 (1H, m), 1.05 (1H, m), 1.18 (1H, m), 1.37 (1H, m), 1.46-1.63 (2H, m), 1.93 (1H, m), 2.43 (1H, m), 2.67 (1H, m), 2.82 (0.6H, s), 2.90-3.14 (3H, m), 2.98 (2.4H, s), 3.21-3.39 (2H, m), 3.88-4.07 (3H, m), 4.50 (0.2H, m), 4.60-4.67 (1H, m), 4.98 (0.8H, m), 6.27 (0.8H, br s, OH), 6.58 (1H, d, J=7.8 Hz), 6.59 (0.2H, br s, OH), 6.74 (1H, d, J=7.8 Hz), 7.53 (1.6H, d, J=8.8 Hz), 7.58 (0.4H, d, J=8.8 Hz), 8.20 (1.6H, d, J=8.8 Hz), 8.23 (0.4H, d, J=8.8 Hz), 8.83 (1H, m, NH+), 9.34 (1H, br s, OH).

IR (KBr)

υ 3358, 1611, 1520, 1468, 1346, 1323, 1118, 1035, 919, 820 cm⁻¹.

Mass (FAB)

m/z 520 ((M+H)+).

Elementary Analysis: As C₂₉H₃₃N₃O₆.HCl.0.7H₂O

Calcd.: C, 61.25; H, 6.27; N, 7.39; Cl, 6.23.

Found.: C, 61.24; H, 6.38; N, 7.18; Cl, 6.37.

Compound 88

mp 230° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.46 (1H, m), 0.60 (1H, m), 0.68 (1H, m), 1.05 (1H, m), 1.18 (1H, m), 1.38 (1H, m), 1.50-1.64 (2H, m), 1.93 (1H, m), 2.42 (1H, m), 2.69 (1H, m), 2.84 (0.6H, s), 2.94 (1H, m), 3.01 (2.4H, s), 3.02-3.14 (2H, m), 3.21-3.33 (2H, m), 3.82-3.97 (3H, m), 4.57 (0.2H, m), 4.61 (0.8H, d, J=3.7 Hz), 4.84 (0.2H, m), 4.98 (0.8H, m), 6.24 (0.8H, br s), 6.46 (0.2H, br s), 6.58 (1H, d, J=7.9 Hz), 6.75 (1H, d, J=7.9 Hz), 7.21 (1H, m), 7.30-7.38 (2H, m), 7.60 (1H, m), 8.82 (1H, br s), 9.34 (0.8H, s), 9.35 (0.2H, s).

IR (KBr)

υ 3120, 1620, 1508, 1473, 1377, 1317, 1118, 1027, 752 cm⁻¹.

Mass (FAB)

m/z 553 ((M+H)+).

Elementary Analysis: As C₂₉H₃₃N₂O₄Br.HCl.0.4H₂O

Calcd.: C, 58.33; H, 5.87; N, 4.69; Cl, 5.94; Br, 13.38.

Found.: C, 58.52; H, 5.76; N, 4.77; Cl, 6.07; Br, 13.03.

Compound 89

mp 243.0-254.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.30 (2H, m), 0.44-0.63 (2H, m), 0.83-0.99 (1H, m), 0.90-1.30 (1H, m), 1.30-1.42 (1H, m), 1.42-1.60 (2H, m), 1.69-1.83 (1H, m), 2.12-2.41 (2H, m), 2.41-2.65 (2H, m), 2.65-2.82 (2H, m), 2.82-2.98 (1H, m), 3.05 (3H, s), 3.05-3.16 (1H, m), 3.16-3.39 (1H, m), 2.80-3.80 (1H, br s), 4.07 (1H, s), 4.55 (0.2H, m), 4.63 (0.8H, d, J=2.9 Hz), 4.68 (0.2H, br s), 4.96 (0.8H, dt, J=13.6, 4.0 Hz), 6.52 (1H, d, J=8.3 Hz), 6.63 (1H, d, J=7.8 Hz), 6.72-6.87 (0.4H, m), 6.96 (0.8H, d, J=15.1 Hz), 7.01 (0.8H, s), 7.43 (1H, d, J=15.1 Hz), 7.72 (0.8H, s), 7.70-7.78 (1H, m), 8.80-9.60 (1H, br s)

IR (KBr)

υ 1651, 1597, 1510, 1460, 1377, 1160, 1120, 1038, 801 cm ⁻¹.

Mass (FAB)

m/z 477 ((M+H)+).

Elementary Analysis: As C₃₀H₃₅N₂O₈.0.8H₂O

Calcd.: C, 63.66; H, 6.52; N, 4.95

Found.: C, 63.42; H, 6.50; N, 4.87

Compound 90

mp 200° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.06 (1H, m), 1.18 (1H, m), 1.38 (1H, m), 1.50-1.64 (2H, m), 1.95 (1H, m), 2.42 (1H, m), 2.67 (1H, m), 2.83 (0.6H, s), 3.00 (2.4H, s), 2.90-3.13 (3H, m), 3.23-3.36 (2H, m), 3.50-4.30 (4H, m), 4.51 (0.2H, m), 4.62 (0.8H, d, J=3.9 Hz), 4.89 (0.2H, m), 4.97 (0.8H, m), 6.32 (1H, br s), 6.59 (1H, d, J=8.3 Hz), 6.75 (1H, d, J=8.3 Hz), 7.81 (2H, d, J=6.8 Hz), 8.79 (2H, d, J=6.8 Hz), 8.85 (1H, br s), 9.38 (1H, br s).

IR (KBr)

υ 3390, 1620, 1510, 1460, 1321, 1120, 803 cm⁻¹.

Mass (EI)

m/z 475 (M+).

Elementary Analysis: As C₂₈H₃₃N₃O₄.1.8HCl.0.4H₂O

Calcd.: C, 61.32; H, 6.54; N, 7.66; Cl, 11.64.

Found.: C, 61.23; H, 6.68; N, 7.55; Cl, 11.59.

Compound 91

mp 249.0-250.0° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.30 (2H, m), 0.44-0.63 (2H, m), 0.83-0.99 (1H, m), 1.10-1.32 (2H, m), 1.32-1.42 (1H, m), 1.42-1.67 (3H, m), 1.69-1.86 (1H, m), 2.18-2.41 (2H, m), 2.41-2.66 (2H, m), 2.66-2.84 (2H, m), 2.84-2.96 (1H, m), 3.06 (3H, s), 3.05-3.16 (1H, m), 3.30 (1H, br s), 4.06 (1H, s), 4.59 (0.2H, m), 4.64 (0.8H, d, J=2.9 Hz), 4.65 (0.2H, brs), 4.97 (0.8H, dt, J=13.7, 2.5 Hz), 6.52 (1H, d, J=7.8 Hz), 6.63 (1H, d, J=8.3 Hz), 6.91 (0.2H, m), 7.07 (0.8H, d, J=15.1 Hz), 7.41-7.50 (0.2H, m), 7.53 (1H, d, J=15.1 Hz), 7.61 (1.8H, s), 7.89 (1H, s), 8.52-9.48 (1H, br s)

IR (KBr)

υ 1638, 1597, 1508, 1460, 1402, 1321, 1118, 1069, 1038, 789 cm⁻¹.

Mass (FAB)

m/z 493 ((M+H)+).

Elementary Analysis: As C₃₀H₃₅N₂O₇S.1.2H₂O

Calcd.: C, 61.14; H, 6.40; N, 4.75; S, 5.44

Found.: C, 61.20; H, 6.39; N, 4.69; S, 5.29

Compound 92

mp 190° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.06 (1H, m), 1.20 (1H, m), 1.38 (1H, m), 1.48-1.64 (2H, m), 1.95 (1H, m),2.41 (1H, m), 2.67 (1H, m), 2.83 (0.6H, s), 3.02 (2.4H, s), 2.90-3.15 (3H, m), 3.22-3.36 (2H, m), 3.40-3.85 (1H, br), 3.93-4.40 (3H, m), 4.58 (0.2H, m), 4.60 (0.8H, d, J=3.9 Hz), 4.97 (1H, m), 6.32 (1H, br s), 6.59 (1H, d, J=8.3 Hz), 6.76 (1H, d, J=8.3 Hz), 7.74-7.83 (2H, m), 8.36 (1H, m), 8.79 (1H, br d, J=3.9 Hz), 8.94 (1H, brs), 9.40 (1H, br s).

IR (KBr)

υ 3380, 1638, 1508, 1460, 1321, 1120, 768 cm⁻¹.

Mass (FAB)

m/z 476 ((M+H)+).

Elementary Analysis: As C₂₈H₃₃N₃O₄.1.8HCl.0.6H₂O

Calcd.: C, 60.92; H, 6.57; N, 7.61; Cl, 11.56.

Found.: C, 60.91; H, 6.82; N, 7.47; Cl, 11.52.

Compound 93

mp 195° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.40 (1H, m), 0.47 (1H, m), 0.61 (1H, m), 0.68 (1H, m), 1.08 (I1H, m), 1.19 (1H, m), 1.38 (1H, m), 1.48-1.64 (2₁, m), 1.95 (1H, m), 2.42 (1H, m), 2.65 (1H, m), 2.83 (0.6H, s), 3.02 (2.4H, s), 2.88-3.15 (3H, m), 3.22-3.36 (2H, m), 3.45-3.80 (1H, br), 3.95-4.23 (3H, m), 4.60 (1H, m), 4.97 (1H, m), 6.32 (1H, br s), 6.59 (1H, m), 6 .7 7(1H, m), 7.91 (1H, m), 8.32 (1H, m), 8.74-8.82 (2H, m), 8.94 (1H, br s), 9.38 (1H, br s).

IR (KBr)

υ 3410, 1626, 1475, 1321, 1120, 1036, 919, 806, 683 cm⁻¹.

Mass (FAB)

m/z 476 ((M+H)+).

Elementary Analysis: As C₂₈H₃₃N₃O₄.1.8HCl.0.75H₂O

Calcd.: C, 60.63; H, 6.60; N, 7.57; Cl, 11.50.

Found.: C, 61.01; H, 6.82; N, 7.17; Cl, 11.49.

Compound 94

mp >265° C. (decomposition)

NMR (400 MHz, CD₃OD)

δ 0.49 (2H, m), 0.73 (1H, m), 0.83 (1H, m), 0.90-1.03 (2H, m), 1.09 (1H, m), 1.15-1.41 (5H, m), 1.43-1.58 (3H, m), 1.63-1.83 (7H, m), 1.92 (1H, m), 2.38-2.52 (2H, m), 2.64 (1H, m), 2.84-3.05 (2H, m), 2.93 (0.6H, s), 3.02 (2.4H, s), 3.05-3.21 (2H, m), 3.23-3.40 (2H, m), 3.98 (1H, m), 4.57 (0.2H, m), 4.75 (1H, br d, J=3.4 Hz), 5.08 (0.8H, ddd, J=13.7, 3.9, 3.9 Hz), 6.67 (0.8H, d, J=8.3 Hz), 6.69 (0.2H, d, J=8.3 Hz), 6.75 (0.8H, d, J=8.3 Hz), 6.76 (0.2H, d, J=8.3 Hz).

IR (KBr)

υ 3342, 3140, 1622, 1508, 1470, 1317, 1172, 1118, 1038, 920, 907, 806 cm⁻¹.

Mass (FAB)

m/z 495 ((M+H)+).

Elementary Analysis: As C₃₀H₄₂N₂O₄.HCl.0.18H₂O

Calcd.: C, 67.43; H, 8.18; N, 5.24; Cl, 6.63.

Found.: C, 67.80; H, 8.01; N, 4.84; Cl, 6.69.

Compound 95

mp 230-240° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.19 (2H, m), 0.45-0.58 (2H, m), 0.90 (1H, m), 0.91 (3H, t, J=7.3 Hz), 1.07-1.37 (2H, m), 1.38-1.55 (4H, m), 1.73 (1H, m), 2.13-2.27 (4H, m), 2.42-2.58 (2H, m), 2.62-2.78 (2H, m), 2.84 (0.6H, s), 2.95 (2.4H, s), 3.03 (1H, br d, J=19.0 Hz), 3.23 (1H, m), 3.50 (3H, br s, 3×OH), 4.02 (1H, s), 4.45 (0.2H, m), 4.56 (0.2H, m), 4.58 (0.8H, d, J=3.4 Hz), 4.90 (0.8H, m), 6.34 (0.2H, d, J=15.1 Hz), 6.45 (0.8H, d, J=15.1 Hz), 6.50 (1H, d, J=8.0 Hz), 6.61 (1H, d, J=8.0 Hz), 6.65-6.73 (1H, m), 9.06 (1H, br s, NH+).

IR (KBr)

υ 3386, 1657, 1591, 1462, 1408, 1359, 1315, 1170, 1122, 1069, 1038, 980, 920, 810 cm⁻¹.

Mass (FAB)

m/z 453 ((M+H)+).

Elementary Analysis: As C₂₇H₃₆N₂O₄.0.5C₄H₆O₆.0.2H₂O

Calcd.: C, 65.57; H, 7.48; N, 5.27.

Found.: C, 65.54; H, 7.35; N, 5.37.

Compound 96

mp 225° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.23 (2H, m), 0.43-0.60 (2H, m), 0.82-0.98 (1H, m), 1.12-1.60 (4H, m), 1.68-1.82 (1H, m), 2.18-2.40 (2H, m), 2.62-2.80 (2H, m), 2.83-4.00 (10H, m), 4.04 (1H, s), 4.52-4.60 (0.3H, m), 4.65 (0.7H, d, J=3.4 Hz), 4.75 (0.3H, br s), 4.92-5.02 (0.7H, m), 6.51 (1H, d, J=7.8 Hz), 6.62 (1H, d, J=7.8 Hz), 7.10-7.26 (1H, m), 7.31 (1H, d, J=15.6 Hz), 7.40-7.57 (3H, m), 7.67 (1H, d, J=10.3 Hz), 9.07 (1H, br s).

IR (KBr)

υ 3400, 1644, 1586, 1462, 1408, 1359, 1315, 1120, 789 cm⁻¹.

Mass (FAB)

m/z 505 ((M+H)+).

Elementary Analysis: As C₃₀H₃₃N₂O₄F.0.5C₄H₆O₆

Calcd.: C, 66.31; H, 6.26; N, 4.83; F, 3.28.

Found.: C, 66.43; H, 6.37; N, 4.87; F, 3.27.

Compound 97

mp 185-200° C.

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.30 (2H, m), 0.45-0.62 (2H₁ m), 0.82-1.00 (1H, m), 1.10-1.60 (4H, m), 1.70-1.85 (1H, m), 2.20-2.35 (2H, m), 2.55-2.90 (5H, m), 2.92 (0.6H, s), 2.97-3.10 (1H, m), 3.12 (2.4H, s), 3.23-3.37 (1H, m), 3.50-5.75 (4H, br), 4.55 (0.2H, m), 4.66 (0.8H, d, J=3.4 Hz), 4.78 (0.2H, m), 4.98 (0.8H, m), 6.53 (1H, d, J=8.1 Hz), 6.64 (1H, d, J=8.1 Hz). 7.29 (0.2H, d, J=15.1 Hz), 7.48 (0.8H, d, J=15.4 Hz), 7.58 (0.2H, d, J=15.1 Hz), 7.63 (0.8H, d, J=15.4 Hz), 7.71 (1H, t, J=8.1 Hz), 8.10-8.27 (2H, m), 8.50 (0.2H, s), 8.61 (0.8H, s).

IR (KBr)

υ 3398, 3360, 3216, 3094, 1649, 1591, 1531, 1350, 1120, 1036, 973, 812, 741

Mass (FAB)

m/z 532 ((M+H)+).

Elementary Analysis : As C₃₀H₃₃N₃O₆.H₃PO₄.1.6H₂O

Calcd.: C, 54.73; H, 6.00; N 6.38; P, 4.70.

Found.: C, 54.66; H, 5.85; N, 6.28; P, 4.45.

Compound 98

mp >176° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.14-0.24 (2H, m), 0.43-0.57 (2H, m), 0.81-0.95 (1H, m), 1.10-1.58 (4H, m), 1.74 (1H, m), 2.16-2.31 (2H, m), 2.40-2.56 (2H, m), 2.62-2.78 (2H, m), 2.84 (0.27H, s), 2.94 (1.71H, s), 2.99-3.08 (1H, m), 3.04 (1.02H, s), 3.25 (1H, m), 3.50 (3H, br s, 3×OH), 4.03 (1H, s), 4.15-4.25 (0.15H, m), 4.20 (0.51H, d, J=16.6 Hz), 4.29 (0.51H, d, J=16.6 Hz), 4.29 (0.09H, d, J=16.6 Hz), 4.36 (0.09H, d, J=16.6 Hz), 4.52 (0.51H, d, J=3.9 Hz), 4.63 (0.34H, d, J=3.9 Hz), 4.72 (0.06H, m), 4.77 (0.09H, m), 4.91 (0.51H, ddd, J=13.7, 3.9, 3.9 Hz), 4.98 (0.34H, ddd, J=13.7, 3.9, 3.9 Hz), 5.97 (0.06H, s), 6.18 (0.34H, s), 6.50-6.56 (1H, m), 6.61-6.67 (1H, m), 7.45-8.02 (5H, m), 9.10 (1H, br s, NH+), 15.84 (0.34H, s), 15.92 (0.06H, s).

IR (KBr)

υ 3400, 1688, 1611, 1464, 1359, 1323, 1214, 1172, 1120, 1069, 1038, 919, 806 cm⁻¹.

Mass (FAB)

m/z 503 ((M+H)+).

Elementary Analysis: As C₃₀H₃₄N₂O₅.0.5C₄H₆O₆.0.7H₂O

Calcd.: C, 65.12; H, 6.56; N, 4.75.

Found.: C, 65.15; H, 6.43; N, 4.74.

Examples 89-94

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylcinnamamido)morphinan.hydrochloride 99 (yield: 46%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-trans-2-hexenamido)morphinan.tartrate 100 (yield: 52%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-phenylpropiolamido)morphinan.hydrochloride 101 (yield: 49%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-fluorocinnamamido)morphinan.tartrate 102 (yield: 81%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylbenzoylacetamido)morphinan.tartrate 103 (yield: 52%) and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-nitrocinnamamido)morphinan.tartrate 104 (yield: 47%) were obtained by following the procedure of example 73 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10 instead of the starting material of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4, and using cinnamic acid, trans-2-hexenoic acid, phenylpropiolic acid, 3-fluorocinnamic acid, benzoylacetic acid and 3-nitrocinnamic acid instead of 3-nitrophenylacetic acid.

Compound 99

mp 225° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.50 (1H, m), 0.59 (1H, m), 0.68 (1H, m), 1.07 (1H, m), 1.20-1.50 (3.5H, m), 1.72 (1H, m), 2.13 (1H, m), 2.40-2.60 (2.5H, m), 2.87 (1H, m), 2.92 (2H, s), 3.06 (2H, m),3.19 (1H, s), 3.32 (2H, m), 3.6-4.3 (2H, m), 4.85 (0.7H, m), 4.92 (0.3H, m), 6.30 (1H, m), 6.68 (2H, m) 6.88 (0.5H, d, J=8.3 Hz), 7.30-7.50 (5H, m), 7.71 (0.5H, d, J=6.4 Hz), 8.79 (1H, m), 9.29 (0.3H, s), 9.70 (0.7H, s)

IR (KBr)

υ 3380, 1642, 1599, 1499, 1321, 1127, 768 cm⁻¹.

Mass (FAB)

m/z 487 (M+H)

Elementary Analysis: As C₃₀H₃₄N₂O₄.HCl.0.3H₂O

Calcd.: C, 68.18; H, 6.79; N, 5.30; Cl, 6.71

Found.: C, 68.06; H, 7.11; N, 5.46; Cl, 6.37

Compound 100

mp >145° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.25 (2H, m), 0.48-0.59 (2H, m), 0.79 (2.1H, t, J=7.3 Hz), 0.90 (0.9H, t, J=7.3 Hz), 0.92 (1H, m), 1.20-1.48 (5H, m), 1.58 (1H, m), 1.91-2.20 (4H, m), 2.29 (1H, m), 2.53 (1H, m), 2.67-2.85 (3H, m), 2.81 (2.1H, s), 3.01 (0.9H, s), 3.11 (1H, br d, J=18.6 Hz), 3.31 (1H, m), 3.45 (4.2H, br s, 3.6×OH+0.6×COOH), 3.57 (1H, m), 4.06 (1.6H, s), 4.62 (0.7H, d, J=7.8 Hz), 4.74 (0.3H, d, J=7.8 Hz), 6.05 (0.7H, d, J=15.1 Hz), 6.35-6.44 (1.0H, m), 6.54-6.71 (2.3H, m), 9.26 (1H, br s, NH+).

IR (KBr)

υ 3396, 1736, 1655, 1601, 1460, 1410, 1319, 1123, 1067, 1035, 922, 859 cm⁻¹.

Mass (FAB)

m/z 453 ((M+H)+).

Elementary Analysis: As C₂₇H₃₆N₂O₄.0.8C₄H₆O₆.1.1H₂O

Calcd.: C, 61.22; H, 7.32; N, 4.73.

Found.: C, 61.13; H, 7.23; N, 4.82.

Compound 101

mp 208.0-225.0° C. (decomposition, ether)

NMR (400 MHz, DMSO-d₆) (data for 0.5 tartrate)

δ 0.25 (2H, br s), 0.54 (2H, m), 0.93 (1H, m), 1.27˜1.47 (3H, m), 1.66 (1H, m), 1.88˜5.20 (3H, br OH×2), 2.08˜2.19 (2H, m), 2.30 (1H, m), 2.44˜2.53 (2H, m), 2.58˜2.80 (3H, m), 2.93 (2.1H, s), 3.12 (1H, m), 3.17 (0.9H, s), 3.27 (1H, br s), 4.00 (1H, s), 4.06 (0.3H, m), 4.20 (0.7H, m), 4.73 (0.7H, d, J=8.3 Hz), 4.82 (0.3H, d, J=8.3 Hz), 6.55-6.67 (2H, m), 7.19 (1.55H, d, J=7.3 Hz), 7.37 (1.55H, t, J=7.3 Hz), 7.45˜7.56 (1.40H, m), 7.60 (0.5H, d, J=6.8 Hz), 9.15 (1H, br s).

IR (KBr) (Data for free base)

υ 3218, 2218, 1618, 1458 cm⁻¹.

Mass (FAB)

m/z 485 (M+H)+.

Elementary Analysis: As C₃₀H₃₃N₂O₄Cl.0.7H₂O

Calcd.: C, 67.52; H, 6.50; N, 5.25; Cl, 6.64.

Found.: C, 67.43; H, 6.65; N, 5.25; Cl, 6.67.

Compound 102

mp 145-153° C.

NMR (400 MHz, DMSO-d₆)

δ 0.20-0.32 (2H, m), 0.46-0.62 (2H, m), 0.88-1.00 (1H, m), 1.20-1.50 (3H, m), 1.55-1.65 (1H, m), 2.00-2.40 (3H, m), 2.42-2.60 (2H, m), 2.70-2.88 (3H, m), 2.90 (2.1H, s), 3.15 (0.9H, m), 3.05-4.00 (7H, m), 4.11 (2H, s), 4.71 (0.7H, d, J=8.1 Hz), 4.81 (0.3H, d, J=8.1 Hz), 6.58-6.68 (3H, m), 7.14-7.68 (5H, m), 9.15 (0.3H, br s), 9.45 (0.7H, br s).

IR (KBr)

υ 3320, 1731, 1647, 1586, 1412, 1311, 1270, 1127, 1077, 1033, 980, 859, 789, 677 cm⁻¹.

Mass (FAB)

m/z 505 ((M+H)+).

Elementary Analysis: As C₃₀H₃₃N₂O₄F.C₄H₆O₆H₂O

Calcd.: C, 60.71; H, 6.14; N, 4.16; F, 2.82.

Found.: C, 60.63; H, 6.22; N, 4.07; F, 2.81.

Compound 103

mp >161° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.17-0.27 (2H, m), 0.45-0.58 (2H, m), 0.89(1H, m), 1.16-1.44 (3H, m), 1.50-1.61 (1H, m), 2.02-2.18 (2H, m), 2.28 (1H, m), 2.43 (1H, m), 2.53-2.78 (3H, m), 2.81 (1.68H, s), 2.93 (0.18H, s), 2.98 (0.72H, s), 3.04 (1H, br d, J=19.1 Hz), 3.10 (0.42H, s), 3.17-3.28 (1H, m), 3.35 (1H, m), 3.50 (3H, br s, 3×OH), 3.98-4.37 (1.4H, m), 4.04 (1H, s), 4.67 (0.8H, d, J=7.8 Hz), 4.76 (0.14H, d, J=8.3 Hz), 4.77 (0.06H, d, J=8.3 Hz), 5.62 (0.06H, s), 6.12 (0.24H, s), 6.52 (0.56H, d, J=8.3 Hz), 6.52-6.78 (0.88H, m), 6.61 (0.56H, d, J=8.3 Hz), 7.41-7.96 (5H, m), 9.02-9.60 (1H, m, NH+), 15.50 (0.06H, s), 15.76 (0.24H, s).

IR (KBr)

υ 3390, 1686, 1626, 1452, 1323, 1278, 1125, 1035, 926, 859 cm⁻¹.

Mass (FAB)

m/z 503 ((M+H)+).

Elementary Analysis: As C₃₀H₃₄N₂O₅.0.5C₄H₆O₆.1.2H₂O

Calcd.: C, 64.14; H, 6.63; N, 4.67.

Found.: C, 64.20; H, 6.57; N, 4.61.

Compound 104

mp 161-164° C.

NMR (400 MHz, DMSO-d₆)

d 0.18-0.30 (2H, m), 0.46-0.60 (2H, m), 0.85-0.97 (1H, m), 1.22-1.50 (3H, m), 1.53-1.62 (1H, m), 2.03-2.21 (2H, m), 2.23-2.35 (1H, m), 2.50-2.90 (4H, m), 2.91 (2.1H, s), 3.18 (0.9H, s), 3.10-4.20 (3H, m), 4.05 (1H, s), 4.67 (0.7H, d, J=8.3 Hz), 4.81 (0.3H, d, J=8.3 Hz), 6.58 (0.3H, d, J=7.8 Hz), 6.63 (1H, d, J=7.8 Hz), 6.73 (0.7H, d, J=7.8 Hz), 6.84 (0.7H, d, J=15.6 Hz), 7.42 (0.3H, d, J=15.9 Hz), 7.45 (0.7H, d, J=15.6 Hz), 7.57 (0.3H, d, J=15.6 Hz), 7.66 (0.7H, dd, J=8.3, 7.8 Hz), 7.71 (0.3H, dd, 8.3, 7.8 Hz), 7.93 (0.7H, d, J=7.8 Hz), 8.15-8.27 (2H, m), 8.60 (0.3H, s), 9.12 (0.3H, br s), 9.28 (0.7H, br s).

IR (KBr)

υ 3380, 1649, 1601, 1531, 1352, 1127, 1035, 922, 859, 810, 743 cm⁻¹.

Mass (FAB)

m/z 532 ((M+H)+).

Elementary Analysis: AS C₃₀H₃₃N₃O₆.0.5C₄H₆O₆.2.2H₂O

Calcd.: C, 59.47; H, 6.30; N, 6.50.

Found.: C, 59.42; H, 5.96; N, 6.25.

Example 95

17 -cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-difluorophenylacetamido)morphinan.hydrochloride 105

128 mg of 3,4-difluorophenylacetic acid and 131 mg of carbonyl diimidazole were dissolved in 2.5 ml of anhydrous tetrahydrofuran. After refluxing while heating for 30 minutes, the solution was cooled to room temperature. A solution of 200 mg of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4 dissolved in 13 ml of anhydrous tetrahydrofuran was added to the reaction solution followed by refluxing while heating for 1 hour. After cooling to room temperature, the reaction solution was concentrated and the resulting residue was dissolved in 16 ml of methanol and stirred for 1 hour following the addition of 1 ml of 1 N aqueous sodium hydroxide. The reaction system was then concentrated followed by the addition of 40 ml of ethylacetate to the residue and sequential washing with 25 ml of water and 25 ml of saturated brine. After drying with anhydrous sodium sulfate, the organic layer was concentrated to obtain 439 mg of crude product. This was then recrystallized from ethylacetate to obtain 190 mg of the free base of the target compound. The mother liquor was then purified with silica gel column chromatography (25 g chloroform/methanol=19/1) to obtain 177 mg of the free base of the target compound. The free base obtained in this manner was then dissolved in a mixed solvent of chloroform and methanol, and this solution was concentrated after adding methanol solution of hydrochloride to adjust to pH 4. The residue was re-precipitated with ether and filtered to obtain 176 mg of the target compound (yield: 57%).

mp 194-208° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 25 0.31-0.43 (1H, m), 0.43-0.53 (1H, m), 0.53-0.64 (1H, m), 0.64-0.76 (1H, m), 0.99-1.12 (1H, m), 1.12-1.28 (1H, m), 1.28-1.45 (1H, m), 1.45-1.67 (2H, m), 1.86-2.03 (1H, m), 2.35-2.50 (1H, m), 2.59-2.77 (1H, m), 2.80 (0.6H, s), 2.88-3.18 (3H, m), 2.96 (2.4H, s), 3.18-3.39 (2H, m), 3.78 (1.6H, s), 3.88 (0.4H, s), 3.91 (1H, d, J=6.8 Hz), 4.49 (0.2H, m), 4.62 (1H, d, J=3.4 Hz), 4.97 (0.8H, dt, J=14.2, 3.4 Hz), 6.25 (0.8H, br s), 6.56 (0.2H, br s), 6.58 (1H, d, J=7.8 Hz), 6.73 (1H, d, J=7.8 Hz), 7.03-7.18 (1H, m), 7.25-7.45 (2H, m), 8.82 (1H, br s) 9.32 (1H, s)

IR (KBr)

υ 1620, 1560, 1520, 1460, 1278, 1172, 1120, 1036, 774 cm⁻¹.

Mass (FAB)

m/z 511 ((M+H)+).

Elementary Analysis: As C₂₉H₃₃N₂O₄ClF₂.0.7H₂O.0.25AcOEt

Calcd.: C, 61.95; H, 6.31; N, 4.82; Cl, 6.09; F, 6.53

Found.: C, 61.91; H, 6.47; N, 4.81; Cl, 6.04; F, 6.53

Examples 96-98

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-benzo[b]thienylacetamido)morphinane.hydrochloride 106 (yield: 74%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-benzo[b]thienylacetamido)morphinan.hydrochloride 107 (yield: 71%) and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-trifluoromethylphenylacetamido) morphinan.hydrochloride 108 (yield: 78%) were obtained by following the procedure of example 95 but using 4-benzo[b]thienylacetic acid, 3-benzo[b]thienylacetic acid and 3-trifluoromethylphenylacetic acid instead of 3,4-difluorophenylacetic acid.

Compound 106

mp 207.0-215.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.42 (1H, m), 0.42-0.53 (1H, m), 0.53-0.65 (1H, m), 0.65-0.74 (1H, m), 1.00-1.11 (1H, m), 1.11-1.29 (1H, m), 1.29-1.48 (1H, m), 1.55 (1H, dd, J=15.1, 9.3 Hz), 1.61 (1H, br d, J=12.2 Hz), 1.88-2.00 (1H, m), 2.42 (1H, dq, J=13.2, 4.9 Hz), 2.60-2.75 (1H, m), 2.81 (0.6H, s), 2.89-2.99 (1H, m), 3.02 (2.4H, s), 3.01-3.15 (2H, m), 3.19-3.32 (2H, m), 3.90 (1H, d, J=6.7 Hz), 4.11 (1.6H, s), 4.20 (0.4H, s), 4.51 (0.2H, br s), 4.63 (0.8H, d, J=3.9 Hz), 4.66 (0.2H, br s), 5.00 (0.8H, dt, J=13.7, 3.4 Hz), 6.22 (0.8H, br s), 6.49 (0.2H, br s), 6.58 (1H, d, J=8.3 Hz), 6.74 (1H, d, J=8.3 Hz), 7.22 (1H, d, J=6.8 Hz), 7.36 (0.8H, t, J=7.6 Hz), 7.35-7.40 (0.2H, m), 7.52 (0.8H, d, J=4.9 Hz), 7.64 (0.2H, d, J=5.9 Hz), 7.76 (0.8H, d, J=5.4 Hz), 7.77 (0.2H, d, J=5.9 Hz), 7.90 (0.8H, d, J=8.3 Hz), 7.92 (0.2H, m), 8.82 (1H, br s), 9.29 (0.2H, s), 9.32 (0.8H, s)

IR (KBr)

υ 1620, 1543, 1508, 1460, 1321, 1120, 1036, 764 cm⁻¹.

Mass (FAB)

m/z 531 ((M+H)+).

Elementary Analysis: As C₃₁H₃₅N₂O₄ClS.0.7H₂O

Calcd.: C, 64.22; H, 6.33; N, 4.83; Cl, 6.12; S, 5.53

Found.: C, 64.13; H, 6.43; N, 4.79; Cl, 6.43; S, 5.24

Compound 107

mp 239-250° C. (decomposition, ethylacetate)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.43 (1H, m), 0.43-0.53 (1H, m), 0.53-0.63 (1H, m), 0.63-0.74 (1H, m), 0.98-1.12 (1H, m), 1.12-1.31 (1H, m), 1.31-1.47 (1H, m), 1.47-1.69 (2H, m), 1.82-2.07 (1H, m), 2.29-2.49 (1H, m), 2.59-2.77 (1H, m), 2.81 (0.6H, s), 2.84-2.98 (1H, m), 3.03 (2.4H, s), 2.98-3.18 (2H, m), 3.18-3.42 (2H, m), 3.81-3.96 (1H, m), 4.00 (1.6H, s), 4.02-4.27 (0.4H, m), 4.32-4.43 (0.2H, m), 4.66 (0.8H, d, J=3.4 Hz), 4.66-4.74 (0.2H, m), 5.00 (1H, dt, J=14.2, 3.3 Hz), 6.22 (0.8H, brs), 6.59 (1H, d, J=7.8 Hz), 6.73 (1H, d, J=8.3 Hz), 7.31-7.48 (2H, m), 7.52 (0.8H, s), 7.64 (0.2H, brs), 7.81 (0.8H, d, J=7.3 Hz), 7.91-8.04 (1.2H, m), 8.81 (1H, br s), 9.28 (0.2H, s), 9.33 (0.8H, s).

IR (KBr)

υ 1620, 1510, 1460, 1321, 1120, 1038 cm⁻¹.

Mass (FAB)

m/z 531 ((M+H)+).

Elementary Analysis: As C₃₁H₃₅N₂O₄ClS.0.5H₂O

Calcd.: C, 64.62; H, 6.29; N, 4.86; Cl, 6.15; S, 5.57

Found.: C, 64.62; H, 6.50; N, 5.00; Cl, 6.08; S, 5.62

Compound 108

mp 192.0-200.0° C. (decomposition, ethylacetate)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.42 (1H, m), 0.42-0.53 (1H, m), 0.53-0.62 (1H, m), 0.62-0.77 (1H, m), 0.96-1.12 (1H, m), 1.12-1.31 (1H, m), 1.31-1.47 (1H, m), 1.47-1.69 (2H, m), 1.82-2.04 (1H, m), 2.30-2.49 (1H, m), 2.59-2.78 (1H, m), 2.81 (0.4H, s), 2.86-3.18 (3H, m), 2.99 (2.6H, s), 3.18-3.40 (2H, m), 3.90 (2H, s), 3.90-4.1 (1H, m), 4.53 (0.2H, m), 4.62 (0.8H, d, J=3.9 Hz), 4.77 (0.2H, br s), 4.98 (0.8H, dt, J=13.7, 3.9 Hz), 6.24 (1H, br s), 6.58 (1H, d, J=7.8 Hz), 6.74 (1H, d, J=8.3 Hz), 7.49-7.68 (4H, m), 8.82 (1H, br s), 9.33 (1H, s)

IR (KBr)

υ 1620, 1508, 1460, 1334, 1166, 1120, 1077, 1036, 801, 702 cm⁻¹.

Mass (FAB)

m/z 543 ((M+H)+).

Elementary Analysis: As C₃₀H₃₄N₂O₄ClF₃.0.5H₂O

Calcd.: C, 61.27; H, 6.00; N, 4.76; Cl, 6.02; F, 9.69

Found.: C, 61.37; H, 6.08; N, 4.75; Cl, 5.89; F, 9.92

Examples 99-110

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-4-chlorophenylacetamido)morphinan.hydrochloride 109 (yield: 78%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-chlorophenylacetamido) morphinan.hydrochloride 110 (yield: 84%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-1-naphthylacetamido)morphinan.hydrochloride 111 (yield: 61%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5(α-epoxy-6β-(N-methyl-2-naphthylacetamido)morphinan.hydrochloride 112 (yield: 63%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-thienylacetamido)morphinan.hydrochloride 113 (yield: 61%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3,4-methylenedioxyphenylacetamido)morphinan.hydrochloride 114 (yield: 45%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-benzo[b]thienylacetamido) morphinan.hydrochloride 115 (yield: 55%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-trifluoromethylphenylacetamido)morphinan.hydrochloride 116 (yield: 57%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-9-fluorenamido)morphinane.hydrochloride 117 (yield: 65%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-2,3,4,5,6-pentafluorophenylacetamido)morphinan.hydrochloride 118 (yield: 68%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-3-(5-chlorobenzo[b]thienyl)acetamido] morphinan.hydrochloride 119 (yield: 83%) and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-4-benzo[b]thienylacetamido)morphinan.hydrochloride 120 (yield: 76%) were obtained by following the procedure of example 95 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10 instead of the starting material of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4, and using 4-chlorophenylacetic acid, 3-chlorophenylacetic acid, 1-naphthylacetic acid, 2-naphthylacetic acid, 3-thienylacetic acid, 3,4-methylenedioxyphenylacetic acid, 3-benzo[b] thienylacetic acid, 3-trifluoromethylphenylacetic acid, 9-fluorenecarboxylic acid, 2,3,4,5,6-pentafluorophenylacetic acid, 3-(5-chlorobenzo[b]thienyl) acetic acid and 4-benzo[b]thienylacetic acid instead of 3,4-difluorophenylacetic acid.

Compound 109

mp 201.0-205.0° C. (decomposition, methanol)

NMR (400 MHz, CD₃OD)

δ 0.31-0.58 (2H, m), 0.61-0.75 (1H, m), 0.75-0.87 (1H, m), 0.87-1.00 (1H, m), 1.00-1.12 (1H, m), 1.12-1.27 (1H, m), 1.35-1.82 (3H, m), 2.06 (1H, dq, J=13.4, 2.7 Hz), 2.42-2.73 (2H, m), 2.73-2.88 (1H, m), 2.92 (2.5H,s), 3.07 (0.5H, s), 2.97-3.20 (3H, m), 3.68 (2H, dd, J=28.8, 15.6 Hz), 3.51-4.38 (2H, m), 4.75 (1H, d, J=8.3 Hz), 6.82 (2H, d, J=8.8 Hz), 6.87 (1H, d, J=7.8 Hz), 7.18 (2H, d, J=8.8 Hz), 7.22 (1H, m)

IR (KBr)

υ 1626, 1493, 1460, 1321, 1125, 1035, 924, 808 cm⁻¹.

Mass (FAB)

m/z 509 ((M+H)+).

Elementary Analysis: As C₂₉H₃₄N₂O₄Cl₃.0.6H₂O

Calcd.: C, 62.61; H, 6.38; N, 5.04; Cl, 12.74

Found.: C, 62.56; H, 6.49; N, 5.02; Cl, 12.64

Compound 110

mp 200.0-209.0° C. (decomposition, methanol)

NMR (400 MHz, CD₃OD)

δ 0.31-0.58 (2H, m), 0.61-0.75 (1H, m), 0.75-0.89 (2H, m), 0.96-1.24 (2H, m), 1.34-1.82 (3H, m), 2.03 (1H, dq, J=13.2, 2.9 Hz), 2.42-2.73 (2H, m), 2.73-2.88 (1H, m), 2.91 (2.5H, s), 3.09 (0.5H, s), 2.97-3.20 (3H, m), 3.54-3.65 (1H, m), 3.68 (2H, s), 3.73-4.97 (1H, m), 4.75 (1H, d, J=8.3 Hz), 6.62-7.39 (6H, m)

IR (KBr)

υ 1620, 1502, 1460, 1321, 1125, 1035, 924, 808 cm⁻¹.

Mass (FAB)

m/z 509 ((M+H)+).

Elementary Analysis: As C₂₉H₃₄N₂O₄Cl₃.0.3H₂O

Calcd.: C, 63.22; H, 6.33; N, 5.08; Cl, 12.87

Found.: C, 63.20; H, 6.50; N, 5.03; Cl, 12.69

Compound 111

mp 210.0-215.0° C. (decomposition, diethylether)

NMR (400 MHz, CD₃OD)

δ 0.31-0.60 (3H, m), 0.61-0.91 (3H, m), 0.91-1.18 (1H, m), 1.31 (1H, brd, J=14.2 Hz), 1.43-1.81 (2H, m), 1.89 (1H, dq, J=13.2, 2.9 Hz), 2.42-2.73 (2H, m), 2.73-3.00 (2H, m), 2.92 (2.6H, s), 3.15 (0.4H, s), 3.00-3.19 (2H, m), 3.54-3.85 (2H, m), 3.99 (1H, d, J=16.1 Hz), 4.23 (1H, d, J=16.1 Hz), 4.75 (1H, d, J=8.3 Hz), 6.80 (1H, d, J=8.30 Hz), 6.90 (1H, d, J=7.82 Hz), 7.00 (1H, d, J=6.84 Hz), 7.27 (1H, t, J=7.6 Hz), 7.31-7.59 (2H, m), 7.70 (2H, t, J=8.30 Hz), 7.80 (1H, d, J=8.3 Hz)

IR (KBr)

υ 1620, 1510, 1502, 1460, 1402, 1321, 1125, 1035, 924, 797 cm⁻¹.

Mass (FAB)

m/z 525 ((M+H)+).

Elementary Analysis: As C₃₃H₃₇N₂O₄Cl.0.3H₂O

Calcd.: C, 69.96; H, 6.69; N, 4.94; Cl, 6.26

Found.: C, 70.04; H, 6.68; N, 5.03; Cl, 6.20

Compound 112

mp 207.0-214.0° C. (decomposition, diethylether)

NMR (400 MHz, CD₃OD)

δ 0.35-0.58 (3H, m), 0.61-0.91 (3H, m), 0.91-1.18 (1H, m), 1.23 (1H, brd, J=14.2 Hz), 1.39-1.81 (2H, m), 1.89 (1H, dq, J=13.2, 2.9 Hz), 2.42-2.76 (2H, m), 2.76-3.02 (2H, m), 2.92 (2.6H, s), 3.10 (0.4H, s), 3.02-3.20 (2H, m), 3.60-3.82 (2H, m), 3.86 (1H, d, J=21.5 Hz), 3.95 (1H, d, J=18.1 Hz), 4.75 (1H, d, J=8.3 Hz), 6.87-7.00 (2H, m), 7.00-7.13 (2H, m), 7.35-7.49 (2H, m), 7.49-7.58 (1H, m), 7.70 (1H, d, J=8.3 Hz), 7.73-7.80 (1H, m)

IR (KBr)

υ 1620, 1504, 1460, 1408, 1321, 1125, 1035, 859, 803, 748 cm⁻¹.

Mass (FAB)

m/z 525 ((M+H)+).

Elementary Analysis: As C₃₃H₃₇N₂O₄Cl

Calcd.: C, 70.64; H, 6.65; N, 4.99; Cl, 6.32

Found.: C, 70.39; H, 6.75; N, 5.05; Cl, 6.00

Compound 113

mp 208.0-219.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.53 (1H, m), 0.53-0,63 (1H, m), 0.63-0.78 (1H, m), 0.84-1.30 (3H, m), 1.30-1.80 (2H, m), 1.90-2.14 (1H, m), 2.30-2.61 (3H, m), 2.83 (2.4H, s), 3.00 (0.6H, s), 2.75-2.91 (1H, m), 2.91-3.17 (3H, m), 3.40-3.57 (2H, m), 3.57-3.72 (1H, m), 3.72-3.88 (1H, m), 4.81 (0.8H, d, J=8.3 Hz), 4.87 (0.2H, d, J=8.3 Hz), 6.30 (0.2H, s), 6.40 (0.8H, s), 6.62 (1H, d, J=4.9 Hz), 6.72 (1H, s), 6.73 (1H, d, J=8.3 Hz), 6.82 (1H, d, J=8.3 Hz), 7.38 (0.8H, dd, J=4.9, 2.9 Hz), 7.47 (0.2H, dd, J=4.9, 2.9 Hz), 8.80 (1H, br s), 9.28 (0.2H, s), 9.65 (0.8H, s)

IR (KBr)

υ 1620, 1508, 1460, 1321, 1125, 1035, 922, 859 cm⁻¹.

Mass (FAB)

m/z 481 ((M+H)+).

Elementary Analysis: As C₂₇H₃₃N₂O₄ClS.0.5H₂O

Calcd.: C, 61.64; H, 6.51; N, 5.32; Cl, 6.74; S, 6.10

Found.: C, 61.77; H, 6.50; N, 5.19; Cl, 6.65; S, 5.83

Compound 114

mp 203.0-208.0° C. (decomposition, ethylacetate, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.54 (1H, m), 0.54-0.63 (1H, m), 0.63-0.73 (1H, m), 0.85-0.99 (1H, m), 0.99-1.10 (1H, m), 1.10-1.29 (1H, m), 1.32-1.80 (3H, m), 1.92-2.13 (1H, m), 2.36-2.55 (2H, m), 2.72-2.92 (1H, m), 2.82 (2.4H, s), 2.99 (0.6H, s), 2.92-3.13 (2H, m), 3.25-3.41 (1H, m), 3.44 (2H, s), 3.48-3.70 (1H, m), 3.82 (1H, br d, J=4.9 Hz), 4.81 (0.8H, d, J=8.3 Hz), 4.87 (0.2H, d, J=8.3 Hz), 5.93 (1.6H, d, J=0.98 Hz), 5.98 (0.4H, s), 6.23 (1H, dd, J=1.3, 8.1 Hz), 6.34 (1H, s), 6.40 (1H, br s), 6.58-6.90 (3H, m), 8.80 (1H, brs), 9.26 (0.2H, s), 9.63 (0.8H, s)

IR (KBr)

υ 1620, 1504, 1491, 1323, 1249, 1125, 1036 cm⁻¹.

Mass (FAB)

m/z 519 ((M+H)+).

Elementary Analysis: As C₃₀H₃₅N₂O₆Cl.0.4H₂O

Calcd.: C, 64.08; H, 6.41; N, 4.98; Cl, 6.31

Found.: C, 64.00; H, 6.43; N, 5.01; Cl, 6.27

Compound 115

mp 215.0-225.0° C. (decomposition, ethylacetate, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.53 (1H, m), 0.53-0.62 (1H, m), 0.62-0.73 (1H, m), 0.79-0.89 (1H, m), 0.89-1.12 (2H, m), 1.34-1.60 (2H, m), 1.98-2.07 (1H, m), 2.39-2.55 (2H, m), 2.73-2.98 (1H, m), 2.85 (2.4H, s), 3.07 (0.6H, s), 2.98-3.13 (2H, m), 3.17-3.39 (2H, m), 3.50-3.61 (1H, m), 3.68 (1H, d, J=16.1 Hz), 3.78 (1H, br d, J=3.9 Hz), 3.88 (1H, d, J=16.1 Hz), 4.83 (0.8H, d, J=8.3 Hz), 4.90 (0.2H, d, J=8.3 Hz), 6.29 (0.2H, s), 6.35 (0.8H, s), 6.03 (0.2H, d, J=8.3 Hz), 6.70 (0.2H, d, J=8.3 Hz), 6.74 (0.8H, d, J=8.3 Hz), 6.82 (0.8H, d, J=8.3 Hz), 7.08 (0.8H, s), 7.21-7.42 (2.8H, m), 7.48 (0.2H, s), 7.77-7.82 (0.2H, m), 7.92 (0.8H, d, J=7.8 Hz), 7.97-8.02 (0.2H, m), 8.78 (1H, br s), 9.28 (0.2H, s), 9.68 (0.8H, s)

IR (KBr)

υ 1626, 1502, 1460, 1319, 1125, 1035 cm⁻¹.

Mass (FAB)

m/z 531 ((M+H)+).

Elementary Analysis: As C₃₁H₃₅N₂O₄ClS.0.4H₂O

Calcd.: C, 64.83; H, 6.28; N, 4.88; Cl, 6.17; S, 5.58

Found.: C, 64.85; H, 6.42; N, 4.89; Cl, 6.15; S, 5.53

Compound 116

mp 195.0-203.0° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.53 (1H, m), 0.53-0.63 (1H, m), 0.63-0.77 (1H, m), 0.96-1.12 (2H, m), 1.12-1.30 (1H, m), 1.30-1.80 (3H, m), 2.06 (1H, br q, J=13.2 Hz), 2.39-2.59 (2H, m), 2.85 (2.4H, s), 3.05 (0.6H, s), 2.71-2.92 (1H, m), 2.92-3.12 (2H, m), 3.41-3.58 (1H, m), 3.68 (1H, d, J=3.4 Hz), 3.58-3.77 (1H, m), 3.77-4.10 (2H, m), 4.84 (0.8H, br d, J=5.4 Hz), 4.88 (0.2H, br d, J=5.4 Hz), 6.30 (0.2H, br s), 6.42 (0.8H, br s), 6.62 (0.2H, d, J=8.3 Hz), 6.69 (0.2H, d, J=8.3 Hz), 6.72 (0.8H, d, J=8.3 Hz), 6.81 (0.8H, d, J=8.3 Hz), 7.13 (0.8H, s), 7.17 (0.2H, d, J=6.8 Hz), 7.22-7.28 (0.2H, m), 7.30 (0.8H, d, J=7.8 Hz), 7.48 (1H, t, J=7.8 Hz), 7.52-7.63 (1H, m), 8.80 (1H, br s), 9.25 (0.2H, s), 9.64 (0.8H, s)

IR (KBr)

υ 1628, 1508, 1460, 1334, 1166, 1127, 1077, 1035, 922, 704 cm⁻¹.

Mass (FAB)

m/z 543 ((M+H)+).

Elementary Analysis: As C₃₀H₃₄N₂O₄ClF₃

Calcd.: C, 62.23; H, 5.92; N, 4.84; Cl, 6.12; F, 9.84

Found.: C, 62.19; H, 6.04; N, 4.82; Cl, 5.76; F, 9.87

Compound 117

mp 215.0-224.0° C. (decomposition, ethylacetate)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.47 (1H, m), 0.47-0.57 (1H, m), 0.57-0.64 (1H, m), 0.64-0.77 (1H, m), 0.98-1.13 (1H, m), 1.20-1.60 (2H, m), 1.60-1.92 (2H, m), 2.31-2.70 (2H, m), 2.79-2.91 (1H, m), 2.97 (2.1H, s), 2.99-3.15 (2H, m), 3.36 (0.9H, s), 3.37-3.60 (2H, m), 3.81 (0.3H, br d, J=5.2 Hz), 3.89 (0.7H, br d, J=5.2 Hz), 3.72-3.93 (0.3H, m), 4.12-4.29 (0.7H, m), 4.90-5.02 (0.3H, m), 5.04 (0.7H, d, J=7.3 Hz), 5.09 (0.7H, s), 5.38 (0.3H, m), 6.17 (0.3H, br s), 6.46 (0.7H, br s), 6.61 (1H, s), 6.55-6.78 (1H, m), 7.08-7.52 (6H, m), 7.64 (1H, d, J=7.3 Hz), 7.84 (1H, dd, J=7.8, 4.4 Hz), 7.91 (1H, d, J=7.3 Hz), 8.77 (0.3H, br s), 8.83 (0.7H, br s), 9.24 (0.3H, s), 9.26 (0.7H, s)

IR (KBr)

υ 1620, 1510, 1460, 748 cm⁻¹.

Mass (FAB)

m/z 549 ((M+H)+).

Elementary Analysis: AS C₃₅H₃₇N₂O₄Cl.0.6H₂O

Calcd.: C, 70.54; H, 6.46; N, 4.70; Cl, 5.95

Found.: C, 70.77; H, 6.54; N, 4.71; Cl, 5.58

Compound 118

mp 208.0-214.0° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.47 (1H, m), 0.47-0.56 (1H, m), 0.56-0.63 (1H, m), 0.63-0.77 (1H, m), 1.00-1.13 (1H, m), 1.20-1.65 (3H, m), 1.74 (1H, br t, J=13.4 Hz), 2.16 (1H, br q, J=12.7 Hz), 2.39-2.62 (2H, m), 2.89 (2.4H, s), 2.76-2.96 (1H, m), 2.96-3.12 (2H, m), 3.17 (0.6H, s), 3.20-3.45 (2H, m), 3.62-3.75 (1H, m), 3.75-3.98 (3H,m), 4.85 (0.8H, d, J=7.8 Hz), 4.94 (0.2H, d, J=7.8 Hz), 6.38 (0.2H, br s), 6.52 (0.8H, brs), 6.62 (0.2H, d, J=8.3 Hz), 6.68 (1H, d, J=8.3 Hz), 6.74 (0.8H, d, J=7.8 Hz), 8.85 (1H, br s), 9.27 (0.2H, s), 9.41 (0.8H, s)

IR (KBr)

υ 1638, 1510, 1315, 1127, 1009, 919, 859 cm⁻¹.

Mass (FAB)

m/z 565 ((M+H)+).

Elementary Analysis: As C₂₉H₃₀N₂O₄ClF₅.0.2H₂O

Calcd.: C, 57.61; H, 5.07; N, 4.63; Cl, 5.86; F, 15.71

Found.: C, 57.60; H, 5.36; N, 4.74; Cl, 5.94; F, 15.51

Compound 119

mp 210.0-219.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.54 (1H, m), 0.54-0.62 (1H, m), 0.62-0.73 (1H, m), 1.00-1.12 (1H, m), 1.19-1.57 (3H, m), 1.61-1.78 (1H, m), 2.00-2.18 (1H, m), 2.40-2.60 (2H, m), 2.73-2.92 (1H, m), 2.87 (2.4H, s), 3.09 (0.6H, s), 2.92-3.13 (2H, m), 3.23-3.41 (2H, m), 3.59-3.69 (0.8H, m), 3.76 (0.8H, d, J=16.5 Hz), 3.80-3.90 (1H, m), 3.89 (0.8H, d, J=16.5 Hz), 3.95 (0.4H, s), 4.00-4.12 (0.2H, m), 4.88 (0.8H, d, J=7.9 Hz), 4.90 (0.2H, d, J=7.9 Hz), 6.35 (0.2H, br s), 6.47 (0.8H, br s), 6.63 (0.2H, d, J=7.9 Hz), 6.69 (1H, d, J=8.5 Hz), 6.78 (0.8H, d, J=7.9 Hz), 7.23 (0.8H, s), 7.36 (0.8H, dd, J=8.6, 1.8 Hz), 7.40 (0.2H, dd, J=8.6, 1.8 Hz), 7.60 (0.2H, s), 7.66 (0.8H, d, J=1.8 Hz), 7.86 (0.2H, d, J=1.8 Hz), 7.97 (0.8H, d, J=8.6 Hz), 8.01 (0.2H, d, J=8.5 Hz), 8.82 (1H, br s), 9.25 (0.2H, s), 9.60 (0.8H, s)

IR (KBr)

υ 1628, 1508, 1427, 1321, 1127, 1079, 1035, 859, 835 cm⁻¹.

Mass (FAB)

m/z 565 ((M+H)+).

Elementary Analysis: As C₃₁H₃₄N₂O₄Cl₂S.0.3H₂O

Calcd.: C, 61.34; H, 5.75; N, 4.62; Cl, 11.68; S, 5.28

Found.: C, 61.40; H, 5.81; N, 4.63; Cl, 11.38; S, 5.20

Compound 120

mp 219.0-226.0° C. (decomposition, diethylether)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.45 (1H, m), 0.45-0.53 (1H, m), 0.53-0.62 (2H, m), 0.62-0.73 (1H, m), 0.77-0.92 (1H, m), 0.97-1.12 (1H, m), 1.43 (1H, d, J=12.2 Hz), 1.47 (1H, d, J=10.3 Hz), 1.91 (1H, br q, J=13.2 Hz), 2.48 (2H, d, J=8.6 Hz), 2.77-2.89 (1H, m), 2.83 (2.4H, s), 2.92 (1H, dd, J=19.5, 6.1 Hz), 3.06 (0.6H, s), 2.99-3.11 (1H, m), 3.25-3.39 (1H, m), 3.51-3.61 (1H, m), 3.78 (1H, d, J=5.4 Hz), 3.85 (1H, d, J=15.4 Hz), 3.89 (1H, d, J=15.4 Hz), 4.83 (0.8H, d, J=8.3 Hz), 4.91 (0.2H, d, J=8.3 Hz), 6.31 (0.2H, br s), 6.37 (0.8H, br s), 6.63 (0.2H, d, J=8.3 Hz), 6.70 (0.2H, dd, J=7.8, 2.0 Hz), 6.77 (0.8H, d, J=8.3 Hz), 6.80-6.90 (1.8H, m), 6.98 (1H, d, J=5.4 Hz), 7.18 (0.8H, t, J=7.8 Hz), 7.31 (0.2H, t, J=7.8 Hz), 7.36 (0.8H, s), 7.50 (0.2H, d, J=4.9 Hz), 7.60 (0.8H, d, J=5.4 Hz), 7.73 (0.2H, d, J=5.9 Hz), 7.82 (0.8H, d, J=8.3 Hz), 7.88 (0.2H, d, J=7.8 Hz), 8.78 (1H, br s), 9.25 (0.2H, s), 9.66 (0.8H, s)

IR (KBr)

υ 1620, 1543, 1516, 1460, 1125, 1033, 766 cm⁻¹.

Mass (FAB)

m/z 531 ((M+H)+).

Elementary Analysis: As C₃₁H₃₅N₂O₄ClS.0.4H₂O

Calcd.: C, 64.83; H, 6.28; N, 4.88; Cl, 6.17; S 5.58

Found.: C, 65.03; H, 6.49; N, 4.78; Cl, 6.03; S, 5.19

Examples 111-113

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(3,4-dichlorophenylacetamido)morphinan.hydrochloride 121 (yield: 54%) and 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan.hydrochloride 122 (yield: 63%), 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3,4-dichlorophenylacetamido) morphinan.hydrochloride 123 (yield: 76%) were obtained by following the procedure of example 95 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-aminomorphinan (J. B. Jiang, R. N. Hanson, P. S. Portoghese and A. E. Takemori, J. Med. Chem., 20, 1100 (1977)), 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 12 and 17-allyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 13 instead of the starting material of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6αmethylaminomorphinan 4, and using 3,4-dichlorophenylacetic acid instead of 3,4-difluorophenylacetic acid. Compound 121

mp 245.0-254.0° C. (decomposition, methanol)

NMR (400 MHz, DMSO-d₆)

δ 0.31-0.46 (1H, m), 0.46-0.53 (1H, m), 0.53-0.63 (1H, m), 0.63-0.75 (1H, m), 0.98-1.12 (1H, m), 1.21-1.39 (1H, m), 1.39-1.57 (2H, m), 1.57-1.80 (2H, m), 2.28-2.48 (2H, m), 2.77-2.92 (1H, m), 3.02 (1H, brd, J=6.4 Hz), 3.07 (1H, br d, J=5.9 Hz), 3.19-3.41 (3H, m), 3.45 (1H, d, J=14.7 Hz), 3.50 (1H, d, J=14.7 Hz), 3.82 (1H, br s), 4.58 (1H, d, J=7.8 Hz), 6.17 (1H, br s), 6.63 (1H, d, J=7.8 Hz), 6.71 (1H, d, J=8.3 Hz), 7.25 (1H, dd, J=8.3, 2.0 Hz), 7.53 (1H, d, J=2.0 Hz), 7.57 (1H, d, J=8.3 Hz), 8.45 (1H, br s), 8.82 (1H, br s), 9.34 (1H, d, J=1.5 Hz)

IR (KBr)

υ 1655, 1545, 1508, 1461, 1128, 1034, 922 cm⁻¹.

Mass (FAB)

m/z 529 ((M+H)+).

Elementary Analysis: As C₂₈H₃₁N₂O₄Cl₃. 0.4H₂O

Calcd.: C, 58.67; H, 5.59; N, 4.89; Cl, 18.56

Found.: C, 58.70; H, 5.65; N, 4.88; Cl, 18.63

Compound 122

mp 214-2160° C.

NMR (400 MHz, DMSO-d₆)

δ 1.16 (1H, m), 1.34 (1H, m), 1.51 (1H, m), 1.62 (1H, m) , 1.86 (1H, m) , 2.41 (1H, m) , 2.72 (1H, m), 2.80 (0.5H, s), 2.95 (2.5H, s), 3.0-3.3 (2H, m), 3.40 (1H, m), 3.52 (1H, m), 3.88 (3H, m), 4.45 (0.2H, m), 4.61 (0.8H, d, J=3.9 Hz), 4.73 (0.2H, m), 4.95 (0.8H, m), 5.57 (2H, m), 5.89 (1H, m), 6.14 (0.8H, brs), 6.48 (0.2H, brs), 6.59 (1H, d, J=8.3 Hz), 6.72 (1H, d, J=8.3 Hz), 7.23 (1H, m), 7.52 (1H, d, J=2.0 Hz), 7.58 (1H, m), 9.12 (1H, brs), 9.32 (1H, s)

IR (KBr)

υ 3300, 1624, 1473, 1118, 1035, 804 cm⁻¹.

Mass (FAB)

m/z 529 (M+H)

Elementary Analysis: As C₂₈H₃₀N₂O₄Cl₂. HCl.0.4H₂O

Calcd.: C, 58.68; H, 5.59; N, 4.89; Cl, 18.56

Found.: C, 58.77; H, 5.66; N, 4.87; Cl, 18.29

Compound 123

mp 185° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 1.15-1.39 (2H, m), 1.44 (0.2H, brd, J=9.2 Hz), 1.51 (0.8H, brd, J=9.8 Hz), 1.61-1.68 (1H, m), 2.00-2.11 (1H, m), 2.44-2.57 (2H, m), 2.83 (2.4H, s), 2.90-3.00 (1H, m), 3.02 (0.6H, s), 3.07-3.15 (1H, m), 3.35-3.39 (0.2H, m), 3.37 (0.8H, d, J=6.7 Hz), 3.43-3.55 (2H, m), 3.57 (1.6H, d, J=3.1 Hz), 3.70-3.79 (1.4H, m), 3.88-4.05 (1H, m), 4.80-4.88 (1H, m), 5.52 (1H, brd, J=11.0 Hz), 5.62 (1H, d, J=7.1 Hz), 5.83-5.96 (1H, m), 6.10-6.38 (1H, m), 6.64 (0.2H, d, J=8.2 Hz), 6.69 (0.2H, d, J=8.2 Hz), 6.73 (0.8H, d, J=8.2 Hz), 6.80 (0.8H, d, J=8.2 Hz), 6.99 (0.8H, dd, J=8.6, 1.8 Hz), 7.10 (0.8H, d, J=1.8 Hz), 7.19-7.23 (0.2H, m), 7.47-7.50 (0.2H, m), 7.50 (0.8H, d, J=8.5 Hz), 7.55 (0.2H, d, J=8.6 Hz), 9.18 (1H, brs), 9.25 (0.2H, s), 9.63 (0.8H, s).

IR (KBr)

υ 3380, 1620, 1502, 1475, 1321, 1125, 1033 cm⁻¹.

Mass (EI)

m/z 528 (M+).

Elementary Analysis: As C₂₈H₃₀N₂O₄Cl₂. HCl. H₂O

Calcd.: C, 57.59; H, 5.70; N, 4.80; Cl, 18.21

Found.: C, 57.93; H, 5.80; N, 4.82; Cl, 17.85

Example 114

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-3-(3-trifluoromethylphenyl)propiolamido] morphinan.hydrochloride 124

400 mg (1.12 mmol) of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10 and 360 mg (1.68 mmol) of 3-(3-trifluoromethylphenyl)propiolic acid were dissolved in 12 ml of chloroform followed by sequential addition of 0.40 ml (2.91 mmol) of N-ethylpiperidine and 428 mg (1.68 mmol) of bis-(2-oxo-3-oxazolidinyl)phosphinic chloride and stirring for 12 hours at room temperature. Then, 15 ml of 1 N aqueous sodium hydroxide were added to separate layers, and the organic layer was washed with 10 ml each of water and saturated brine, dried and concentrated. The residue was dissolved in 10 ml of methanol followed by the addition of 2 ml of 1 N aqueous sodium hydroxide and stirring for 3 hours. 30 ml of ethylacetate were then added to separate layers, and the resulting organic layer was washed with 20 ml of saturated brine, dried and concentrated. The residue was purified with silica gel column chromatography (Merk 9385, 30 g, chloroform/methanol=30/1) to obtain 562.8 mg of the free base of the target compound. This was then re-precipitated from hexane and ethylacetate, and the resulting solid was dissolved in ethylacetate. An excess amount of ethylacetate solution of hydrochloride solution was added followed by stirring and filtration of the resulting precipitate to obtain 274 mg of the target compound (yield: 42%).

mp>195° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0. 52 (1H, m), 0. 59 (1H, m), 0.67 (1H, m), 1.07 (1H, m), 1.29-1.51 (3H, m), 1.73-1.83 (1H, m), 2.09-2.26 (1H, m), 2.40-2.58 (2H, m), 2.86 (1H, m), 2.98 (2.4H, s), 3.02-3.11 (2H, m), 3.31 (0.6H, s), 3.30-3.38 (2H, m), 3.87 (1H, br d, J=5.9 Hz), 4.13 (1H, m), 4.89 (0.8H, d, J=8.3 Hz), 4.96 (0.2H, d, J=8.3 Hz), 6.40 (0.2H, s, OH), 6.46 (0.8H, d, J=7.3 Hz), 6.53 (0.8H, s, OH), 6.60 (0.8H, d, J=7.3 Hz), 6.66 (0.2H, d, J=7.3 Hz), 6.72 (0.2H, d, J=7.3 Hz), 7.47 (0.8H, br s), 7.57 (0.8H, d, J=7.8 Hz), 7.63 (0.8H, dd, J=7.8, 7.8 Hz), 7.73 (0.2H, dd, J=7.8, 7.8 Hz),7.83 (0.8H, d, J=7.8 Hz), 7.90 (0.2H, d, J=7.8 Hz), 7.97 (0.2H, d, J=7.8 Hz), 8.06 (0.2H, br s), 8.81 (1H, m, NH+), 9.30 (0.8H, s, OH), 9.31 (0.2H, s, OH).

IR (KBr)

υ 3400, 2224, 1620, 1439, 1334, 1170, 1127, 1073, 1035, 924, 806 cm⁻¹.

Mass (FAB)

m/z 553 ((M+H)+).

Elementary Analysis: As C₃₁H₃₁F₃N₂O₄.HCl.0.5H₂O

Calcd.: C, 62.26; H, 5.56; Cl, 5.93; F, 9.53; N, 4.68

Found.: C, 62.25; H, 5.64; Cl, 5.78; F, 9.49; N, 4.73

Example 115

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[N-methyl-3-(3-trifluoromethylphenyl)propiolamido] morphinan. hydrochloride 125 was obtained by following the procedure of example 114 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4 instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10.

mp>190° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0.48 (1H, m), 0.62 (1H, m), 0.68 (1H, m), 1.07 (1H, m), 1.14-1.33 (1H, m), 1.48-1.70 (3H, m), 1.92-2.07 (1H,m), 2.47 (1H, m), 2.70 (1H, m), 2.92-3.15 (3H, m)), 2.93 (1.2H, s), 3.22-3.38 (2H, m), 3.26 (1.8H, s), 3.96 (1H, m), 4.72 (0.6H, d, J=3.4 Hz), 4.85 (0.4H, d, J=3.4 Hz), 4.92 (0.6H, ddd, J=14.2, 3.9, 3.9 Hz), 5.07 (0.4H, ddd, J=13.2, 3.9, 3.9 Hz), 6.34 (0.6H, s, OH), 6.43 (0.4H, s, OH), 6.61 (0.6H, d, J=7.8 Hz), 6.61 (0.4H, J=7.3 Hz), 6.75 (0.6H, d, J=7.8 Hz), 6.75 (0.4H, d, J=7.3 Hz), 7.73 (0.6H, dd, J=7.8, 7.3 Hz), 7.82 (0.4H, dd, J=7.8, 7.3 Hz), 7.91 (0.6H, d, J=7.3 Hz), 7.92 (0.4H, d, J=7.3 Hz), 7.98 (0.6H, d, J=7.8 Hz), 8.06 (0.6H, br s), 8.06 (0.4H, d, J=7.8 Hz), 8.08 (0.4H, br s), 8.82-8.94 (1H, m, NH+), 9.38 (0.4H, s, OH), 9.38 (0.6H, s, OH).

IR (KBr)

υ 3400, 2220, 1611, 1460, 1334, 1172, 1122, 1071, 1036, 922, 806 cm⁻¹.

Mass (FAB)

m/z 553 ( (M+H)+).

Elementary Analysis: As C₃₁H₃₁F₃N₂O₄. HCl. 0.6H₂0

Calcd.: C, 62.07; H, 5.58; Cl, 5.91; F, 9.50; N, 4.67

Found.: C, 61.96; H, 5.64; Cl, 6.06; F, 9.47; N, 4.69

Example 116

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido] morphinan.0.5 tartrate 126 was obtained by following the procedure of example 114 but using 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-methylaminomorphinan 4 instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-methylaminomorphinan 10, and using 3-(4-trifluoromethylphenyl)propiolic acid instead of 3-(3-trifluoromethylphenyl)propiolic acid.

mp 197.0° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.10-0.30 (2H, m), 0.44-0.63 (2H, m), 0.83-0.99 (1H, m), 1.10-1.35 (1H, m), 1.40-1.60 (3H, m), 1.70-1.88 (1H, m), 2.15-2.34 (2H, m), 2.39-2.62 (2H, m), 2.62-2.84 (2H, m), 2.93 (1.5H, s), 3.00-3.13 (1H, m), 3.25 (1.5H, s), 3.20-3.34 (1H, m), 2.40-4.40 (3H, br s), 4.10 (1H, s), 4.62 (0.5H, br d, J=3.4 Hz), 4.70 (0.5H, br d, J=2.9 Hz), 4.85 (0.5H, ddd, J=14.2, 3.9, 3.9 Hz), 5.03 (0.5H, ddd, J=13.2, 3.9, 3.9 Hz), 6.53 (1H, d, J=8.3 Hz), 6.64 (0.5H, d, J=7.8 Hz), 6.65 (0.5H, d, J=8.3 Hz), 7.85 (1H, d, J=8.3 Hz), 7.89 (1H, d, J=8.3 Hz), 7.90 (1H, d, J=8.3 Hz), 7.93 (1H, d, J=8.3 Hz), 8.80-9.60 (1H, br s).

IR (KBr)

υ 3416, 2222, 1609, 1508, 1406, 1325, 1125, 1067 cm⁻¹.

Mass (FAB)

m/z 553 ( (M+H)+)

Elementary Analysis: As C₃₁H₃₁F₃N₂O₄.0.5C₄H₆O₆.0.5H₂O

Calcd.: C, 62.26; H, 5.54; F, 8.95; N, 4.40

Found.: C, 62.14; H, 5.58; F, 8.91; N, 4.43

Example 17

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-3-(4-trifluoromethylphenyl)propiolamido] morphinan.hydrochloride 127 was obtained by following the procedure of example 114 but using 3-(4-trifluoromethylphenyl)propiolic acid instead of 3-(3-trifluoromethylphenyl)propiolic acid.

mp 197.0° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.35-0.46 (1H, m), 0.46-0.56 (1H, m),0.56-0.64 (1H, m), 0.64-0.75 (1H, m), 1.01-1.15 (1H, m), 1.27-1.37 (0.6H, m), 1.37-1.52 (2.4H, m), 1.70-1.85 (1H, m), 2.05-2.30 (1H, m), 2.36-2.62 (2H, m), 2.80-2.92 (1H, m), 2.99 (2.4H, s), 3.00-3.16 (2H, m), 3.32 (0.6H, s), 3.30-3.40 (2H, m), 3.86 (1H, br d, J=4.4 Hz), 4.05-4.18 (1H, m), 4.90 (0.8H, d, J=8.3 Hz), 4.97 (0.2H, d, J=8.8 Hz), 6.43 (0.2H, s), 6.55 (0.8H, s), 6.57 (0.8H, d, J=7.8 Hz), 6.66 (1H, d, J=8.3 Hz), 6.72 (0.2H, d, J=7.8 Hz), 7.43 (1.6H, d, J=7.8 Hz), 7.74 (1.6H, d, J=8.3 Hz), 7.85 (0.4H, d, J=8.8 Hz), 7.89 (0.4H, d, J=8.8 Hz), 8.83 (1H, br s), 9.32 (0.2H, s), 9.35 (0.8H, s).

IR (KBr)

υ 3416, 2224, 1618, 1508, 1408, 1325, 1172, 1127, 1067 cm⁻¹.

Mass (FAB)

m/z 553 ((M+H)+).

Elementary Analysis: As C₃₁H₃₁F₃N₂O₄. HCl.0.6H₂O

Calcd.: C, 62.07; H, 5.58; Cl, 5.91; F, 9.50; N, 4.67

Found.: C, 62.14; H, 5.62; Cl, 5.90; F, 9.29; N, 4.62

Example 118

17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylmethanesulfonamido) morphinan.tartrate 128

227 mg of 3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylmethanesulfonamido)morphinan 16 obtained in reference example 8 was dissolved in 4.5 ml of tetrahydrofuran followed by the addition of 0.39 ml of tetrabutylammonium fluoride and stirring for 30 minutes. 15 ml of ethylacetate and 10 ml of saturated aqueous ammonium chloride were added to separate layers, and the aqueous layer was extracted twice with 10 ml of ethylacetate. The resulting organic layer was concentrated after drying with anhydrous sodium sulfate, and the residue was purified with silica gel column chromatography (25 g chloroform/methanol=20/1) to obtain the crude compound. This was then recrystallized from ethylacetate and methanol to obtain 158 mg of the free base of the target compound. This was dissolved in a mixed solvent of chloroform and methanol, completely dissolved by addition of 20.4 mg of tartaric acid and concentrated. This residue was re-precipitated from methanol and ether followed by filtration to obtain 105 mg of the target compound (yield: 49%).

mp>149° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.13-0.22 (2H, m), 0.47-0.58 (2H, m), 0.82-0.92 (1H, m), 0.98-1.11 (1H, m), 1.18-1.27 (1H, m), 1.35-1.48 (2H, m), 1.55-1.67 (1H, m), 2.07-2.26 (2H, m), 2.48-2.60 (1H, m), 2.60-2.73 (2H, m), 2.83 (3H, s), 3.01 (1H, brd, J=8.6 Hz), 2.90-4.00 (5H, m, 3×OH), 3.98-4.07 (1H, m), 4.11 (1H, s), 4.35 (1H, d, J=3.4 Hz), 4.49 (1H, d, J=13.7 Hz), 4.53 (1H, d, J=13.7 Hz), 6.49 (1H, d, J=8.3 Hz), 6.61 (1H, d, J=8.3 Hz), 7.44 (1H, dd, J=2.0, 8.3 Hz), 7.67 (1H, d, J=8.3 Hz), 7.71 (1H, d, J=2.0 Hz), 9.08 (1H, brs).

IR (KBr)

υ 3410, 1607, 1470, 1323, 1122, 1035, 959, 917 cm⁻¹.

Mass (FAB)

m/z 579 (M+H)+.

Elementary Analysis: As C₂₈H₃₂N₂O₅Cl₂S.0.65C₄H₆N₆.0.4H₂O

Calcd.: C, 53.71; H, 5.41; N, 4.09; Cl, 10.36; S, 4.69

Found.: C, 53.79; H, 5.50; N, 4.12; Cl, 10.09; S, 4.58

Example 119

17-Cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylphenylmethanesulfonamido)morphinan.tartrate 129 (yield: 87%) was obtained by following the procedure of example 118 but using 3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-phenylmethanesulfonamido)morphinan 17 instead of the starting material of 3-tert-butyldimethylsilyloxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylmethanesulfonamido)morphinan 16.

mp>147° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.13-0.22 (2H, m), 0.45-0.58 (2H, m), 0.82-1.07 (2H, m), 1.09-1.19 (1H, m), 1.33-1.42 (2H, m), 1.50-1.62 (1H, m), 2.07-2.27 (2H, m), 2.40-2.72 (3H, m) , 2.79 (3H, s) , 2.99 (1H, brd, J=9.0 Hz), 2.95-4.15 (5H, m, 3×OH), 3.98-4.07 (1H, m), 4.10 (1H, s), 4.34 (1H, d, J=3.4 Hz), 4.40 (1H, d, J=13.9 Hz), 4.45 (1H, d, J=13.9 Hz), 6.47 (1H, d, J=8.0 Hz), 6.61 (1H, d, J=8.0 Hz), 7.31-7.46 (5H, m), 9.10 (1H, brs).

IR (KBr)

υ 3420, 1603, 1460, 1321, 1122, 1069, 1036, 959, 917 cm⁻¹.

Mass (FAB)

m/z 511 (M+H)+.

Elementary Analysis: As C₂₈H₃₄N₂O₅S.0.5C₄H₆N₆.H₂O

Calcd.: C, 59.67; H, 6.51; N, 4.64; S, 5.31

Found.: C, 59.50; H, 6.47; N, 4.68; S, 5.21

Example 120

17-cycloproylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(3-phenylpropionyloxy)morphinanan.tartrate 130

148 mg of 17-cyclopropylmethyl-4,5α-epoxy-3,6α,14β-trihydroxymorphinan (N. Chatterjie, C. E. Inturrisi, H. B. Dayton and H. Blumberg, J. Med. Chem., 18, 490 (1975); H.C. Brown and S. Krishnamurthy, J. Am. Chem. Soc., 94, 7159 (1972)) was dissolved in 0.9 ml of carbon tetrachloride and 0.3 ml of methylene chloride followed by the addition of 0.225 ml diisopropylethylamine and 26 mg of 4-dimethylaminopyridine, and the dropwise addition of 0.13 ml of 3-phenylpropionyl chloride at 0° C. After stirring for 20 hours at room temperature, 2 ml of saturated aqueous sodium bicarbonate was added to the reaction system to separate layers, and the aqueous layer was extracted twice with chloroform. The organic layer was concentrated after drying with anhydrous sodium sulfate. The resulting residue was dissolved in a mixed solvent of chloroform and methanol followed by the addition of 30 mg of potassium carbonate and stirring for 1 hour. Water was then added to the reaction mixture to separate layer, and the aqueous layer was extracted twice with chloroform. The resulting organic layer was concentrated after drying with anhydrous sodium sulfate, and the residue was purified with silica gel column chromatography (15 g chloroform/methanol=20/1) to obtain 95.3 mg of the free base of the target compound. This was then dissolved in methanol, completely dissolved by addition of 15 mg of tartaric acid and concentrated. The residue was re-precipitated from ether followed by filtration to obtain 103 mg of the target compound (yield: 43%).

mp >110° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.18-0.28 (2H, m), 0.47-0.60 (2H, m), 0.83-0.95 (1H, m), 1.19-1.28 (1H, m), 1.32-1.49 (3H, m), 1.74-1.82 (1H, m), 2.19-2.29 (2H, m), 2.40-2.47 (2H, m), 2.55-2.80 (6H, m), 3.08 (1H, brd, J=18.9 Hz), 3.28 (1H, brs), 3.36 (5H, m), 4.10 (2H, s), 4.64 (1H, d, J=4.9 Hz), 5.27-5.31 (1H, m), 6.51 (1H, d, J=8.2 Hz), 6.63 (1H, d, J=8.2 Hz), 7.13-7.19 (3H, m), 7.22-7.28 (2H, m), 9.10 (1H, brs).

IR (KBr)

υ 3400, 1719, 1460, 1307, 1267, 1122, 1069, 1036 cm⁻¹.

Mass (FAB)

m/z 476 (M+H)+.

Elementary Analysis: As C₂₉H₃₃NO₅.0.95C₄H₆O₆.1/6C₄H₁₀O. 1/6C₂H₆O.0.4H₂O

Calcd.: C, 62.91; H, 6.59; N, 2.17

Found.: C, 62.92; H, 6.56; N, 2.32

Example 121

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5β-epoxy-6α[N-methyl-N′-(3,4-dichlorophenyl)ureido]morphinan. hydrochloride 131

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-methylaminomorphinan A (0.20 g) was dissolved in chloroform (5 ml) followed by the addition of 3,4-dichlorophenylisocyanate (0.26 g, 2.5 equivalents) and reacting for 5 minutes at room temperature. The precipitated solid was filtered out and dissolved in chloroform (8 ml) and methanol (10 ml) followed by the addition of 3 N aqueous sodium hydroxide to carry out hydrolysis for 5 minutes at room temperature. The solvent was distilled off followed by addition of saturated aqueous sodium bicarbonate (10 ml) and distilled water (4 ml), extraction with chloroform and methanol (12/2+10/2 ml), and drying with anhydrous sodium sulfate. After purifying with silica gel column chromatography (Merk 9385, 20 g; chloroform →3% methanol/chloroform), the residue was again dissolved in chloroform and methanol (5/0.5 ml) followed by addition of methanol solution of hydrochloric acid to obtain the target compound (0.23 g, 70%) in the form of its hydrochloride.

mp 210° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0.44 (1H, m), 0.62 (1H, m), 0.68 (1H, m), 1.0-1.2 (2H, m), 1.40 (1H, m), 1.60 (2H, m), 1.94 (1H, m), 2.4-2.5 (1H, m), 2.68 (1H, m), 2.92 (3H, s), 2.9-3.2 (3H, m), 3.3-3.4 (2H, m), 3.91 (1H, d, J=6.8 Hz), 4.74 (1H, d, J=3.9 Hz), 4.81 (1H, dt, J=13.7, 3.9 Hz), 6.34 (1H, s), 6.59 (1H, d, J=7.8 Hz), 6.73 (1H, d, J=7.8 Hz), 7.49 (1H, d, J=8.8 Hz), 7.55 (1H, dd, J=9.3, 2.4 Hz), 7.94 (1H, d, J=2.4 Hz), 8.73 (1H, s), 8.82 (1H, brs), 9.32 (1H, s)

IR (KBr)

υ 3300, 1638, 1510, 1477, 1120, 1040 cm⁻¹.

Mass (FAB)

m/z 544 (M+H)

Elementary Analysis: As C₂₈H₃₁N₃O₄Cl₂.HCl.0.4H₂O

Calcd.: C 57.18; H 5.62; N 7.14; Cl 18.08

Found.: C 57.32; H 5.83; N 7.04; Cl 17.85

Examples 122-124

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-N′-benzylureido)morphinan.tartrate 132 (yield: 65%), 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-N′-benzylthioureido)morphinan.tartrate 133 (yield: 88%) and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-N′-benzylthioureido)morphinan.tartrate 134 (yield: 74%) were obtained by following the procedure of example 121 but using benzylisocyanate and benzylisothiocyanate instead of 3,4-dichlorophenylisocyanate, and using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-methylaminomorphinan 10 instead of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-methylaminomorphinan 4.

Compound 132

mp 202-205° C. (decomposition, methanol-ethylacetate)

NMR (400 MHz, DMSO-d₆)

δ 0.28 (2H, m). 0.52 (2H, m), 0.89 (1H, m), 1.10 (1H, m), 1.24 (1H, m), 1.38-1.53 (2H, m), 1.73 (1H, m), 2.15-2.30 (2H, m), 2.62-2.76 (2H, m), 2.78 (3H, s), 3.04 (1H, br d, J=18.6 Hz), 3.24 (1H, m), 3.39-3.52 (2H, m), 3.53 (3H, br s, 3×OH), 3.99 (1H, s), 4.28 (2H, d, J=5.9 Hz), 4.53 (1H, d, J=3.4 Hz), 4.70 (1H, m), 6.49 (1H, d, J=8.1 Hz), 6.61 (1H, d, J=8.1 Hz), 6.89 (1H, t, J=5.9 Hz, NH), 7.18-7.34 (5H, m), 9.03 (1H, br s, NH+).

IR (KBr)

υ 3422, 3204, 1630, 1615, 1589, 1535, 1468, 1359, 1319, 1123, 903, 735 cm⁻¹.

Mass (FAB)

m/z 490 ( (M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₄.0.5C₄H₆O₆

Calcd.: C, 65.94; H, 6.78; N, 7.44

Found.: C, 65.95; H, 6.74; N, 7.47

Compound 133

mp 155-195° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.29 (2H, m), 0.52 (2H, m), 0.90 (1H, m), 1.18 (1H, m), 1.35 (1H, m), 1.43 (1H, br d, J=9.1 Hz), 1.50 (1H, dd, J=14.6, 9.1 Hz), 1.77 (1H, m), 2.18-2.28 (2H, m), 2.42-2.57 (2H, m), 2.66-2.78 (2H, m), 2.95 (3H, s), 3.04 (1H, br d, J=18.9 Hz), 3.23 (1H, m), 3.48 (3H, br s, 3×OH), 4.01 (1H, s), 4.80 (1H, d, J=3.6 Hz), 4.82 (1H, dd, J=15.3, 6.1 Hz), 4.89 (1H, dd, J=15.3, 6.1 Hz), 5.81 (1H, m), 6.51 (1H, d, J=7.9 Hz), 6.62 (1H, d, J=7.9 Hz), 7.23 (1H, m), 7.28-7.33 (4H, m), 8.01 (1H, dd, J=6.1, 6.1 Hz, NH), 9.03 (1H, br s, NH+).

IR (KBr)

υ 3374, 1605, 1535, 1460, 1381, 1330, 1243, 1176, 1118, 1067, 1036, 907, 698 cm⁻¹.

Mass (FAB)

m/z 506 ( (M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₃S.0.5C₄H₆O₆.0.3H₂O. 0.15CH₃COOC₂H₅

Calcd.: C, 63.33; H, 6.69; N, 7.01; S, 5.35

Found.: C, 63.44; H, 6.56; N, 6.90; S, 5.35

Compound 134

mp 160-180° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.22 (2H, m), 0.47-0.58 (2H, m), 0.91 (1H, m), 1.27-1.47 (3H, m), 1.55 (1H, m), 1.94 (1H, m)), 2.12 (1H, m), 2.28 (1H, m), 2.43-2.78 (5H, m), 3.07 (1H, m), 3.08 (3H, s), 3.26 (1H, m), 3.50 (3.6H, br s, 3.3×OH+0.3×COOH), 4.01 (1.3H, s), 4.60 (1H, dd, J=15.3, 4.9 Hz), 4.74 (1H, d, J=8.3 Hz), 4.93 (1H, dd, J=15.3, 5.9 Hz), 6.55 (1H, d, J=8.3 Hz), 6.60 (1H, d, J=8.3 Hz), 7.19-7.34 (5H, m), 7.95 (1H, dd, J=5.9, 4.9 Hz, NH), 9.11 (1H, br s, NH+).

IR (KBr)

υ 3352, 1721, 1605, 1531, 1456, 1330, 1238, 1125, 1067, 1033, 915, 859 cm⁻¹.

Mass (FAB)

m/z 506 ((M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₃S.0.65C₄H₆O₆.0.4H₂O

Calcd.: C, 62.18; H, 6.56; N, 6.88; S, 5.25

Found.: C, 62.09; H, 6.74; N, 6.83; S, 5.21

Example 125

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-[N-methyl-N-2-(3,4-dichlorophenyl)ethylamino]morphinan.1.8 hydrochloride 135

234.5 mg (0.431 mmol) of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan (free base of 1) was dissolved in 5.0 ml of anhydrous THF under argon atmosphere followed by the dropwise addition of 1.1 ml (2.2 mmol) of a 2.0 M anhydrous THF solution of borane-dimethylsulfide complex at 0° C. and refluxing for 1.5 hours. This reaction solution was cooled to 0° C. followed by the addition of 2 ml of 6 N hydrochloric acid and again refluxing for 1 hour. The reaction solution was again cooled to 0° C. and 25 ml of saturated aqueous sodium bicarbonate was added to make the solution basic. The solution was then extracted with chloroform and methanol (4:1) (3×20 ml), and the organic layers were combined, dried and concentrated to obtain 281 mg of an oily substance. This oily substance was purified with column chromatography [silica gel 25 g; chloroform-methanol (50:1→40:1)] to obtain 191.0 mg of the free base of the target compound. This free base was dissolved in methanol followed by the addition of a methanol solution of hydrogen chloride and concentration. The resulting hydrochloride was purified with Sephadex gel column chromatography [methanol] to obtain 193.3 mg of the target compound (yield: 74%).

mp>205° C. (decomposition)

NMR (400 MHz, CDCl₃; data for free base)

δ 0.13 (2H, m), 0.53 (2H, m), 0.85 (1H, m), 1.00 (1H, m), 1.49 (1H, dd, J=15.1, 8.8 Hz), 1.53-1.62 (2H, m), 1.71 (1H, ddd, J=15.1, 9.5, 9.5 Hz), 2.0-3.1 (1H, br s, OH), 2.15-2.40 (4H, m), 2.51 (3H, s), 2.55-2.67 (2H, m), 2.72-2.85 (3H, m), 2.89 (1H, m), 2.98-3.10 (3H, m), 4.78 (1H, dd, J=3.0, 2.0 Hz), 4.98 (1H, br s, OH), 6.50 (1H, d, J=8.1 Hz), 6.68 (1H, d, J=8.1 Hz), 7.03 (1H, dd, J=8.3, 2.0 Hz), 7.28 (1H, d, J=2.0 Hz), 7.33 (1H, d, J=8.3 Hz).

IR (KBr)

υ 3422, 1638, 1620, 1508, 1470, 1390, 1323, 1241, 1172, 1122, 1035, 982, 919, 886 cm⁻¹.

Mass (FAB)

m/z 529 ( (M+H)+).

Elementary Analysis: As C₂₉H₃₄Cl₂N₂O₃.1.8HCl.0.4H₂O

Calcd.: C, 57.83; H, 6.12; N, 4.65; Cl, 22.37

Found.: C, 57.73; H, 6.31; N, 4.60; Cl, 22.38

Example 126

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-N-2-(3,4-dichlorophenyl)ethylamino]morphinan.1.9 hydrochloride 136 (yield: 65%) was obtained by following the procedure of example 125 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3,4-dichlorophenylacetamido)morphinan (free base of 53) instead of the starting material of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan (free base of 1).

Compound 136

mp>185° C. (decomposition)

NMR (400 MHz, CDCl₃; data of free base);

δ 0.12 (2H, m), 0.52 (2H, m), 0.83 (1H, m), 1.29 (1H, ddd, J=13.2, 13.2, 2.9 Hz), 1.44 (1H, m), 1.51 (1H, m), 1.61 (1H, ddd, J=13.2, 2.9, 2.9 Hz), 1.86 (1H, m), 2.0-3.8 (2H, br s, 2×OH), 2.11 (1H, ddd, 11.7, 11.7, 3.4 Hz), 2.21 (1H, ddd, J=12.2, 12.2, 4.9 Hz), 2.33-2.38 (2H, m), 2.41 (3H, s), 2.47-2.56 (2H, m), 2.57-2.75 (4H, m), 2.81 (1H, m), 2.97-3.06 (2H, m), 4.56 (1H, d, J=8.3 Hz), 6.56 (1H, d, J=8.1 Hz), 6.71 (1H, d, J=8.1 Hz), 7.01 (1H, dd, J=8.3, 2.0 Hz), 7.29 (1H, d, J=2.0 Hz), 7.30 (1H, d, J=8.3 Hz).

IR (KBr)

υ 3250, 1638, 1618, 1473, 1398, 1330, 1241, 1218, 1116, 1035, 982, 919, 855, 756 cm⁻¹.

Mass (FAB)

m/z 529 ((M+H)+).

Elementary Analysis: As C₂₉ H₃₄Cl₂N₂O₃. 1.9 HCl.0.5H₂O

Calcd.: C, 57.31; H, 6.12; N, 4.61; Cl, 22.75

Found.: C, 57.40; H, 6.22; N, 4.55; Cl, 22.54

Example 127

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-aminophenylacetamido)morphinanan.1.6 hydrochloride 137

156.8 mg (0.282 mmol) of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-nitrophenylacetamido) morphinan.hydrochloride 87 was dissolved in 2.1 ml of methanol followed by the addition of roughly 0.2 ml of a saturated methanol solution of hydrogen chloride gas and 5.3 mg of platinum oxide, and stirring for 2.5 hours at room temperature in a hydrogen atmosphere (1 atm). The reaction mixture was filtered by passing through Celite, and the filtration residue was washed with methanol. The filtrate and washing were combined and concentrated to obtain 166 mg of crude product. This crude product was purified twice with Sephadex column chromatography [methanol] to obtain 108.2 mg of the target compound (yield: 68%).

mp>220° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.39 (1H, m), 0.47 (1H, m), 0.62 (1H, m), 0.69 (1H, m), 1.00-1.23 (2H, m), 1.34 (1H, m), 1.45-1.63 (2H, m), 1.94 (1H, m), 2.44 (1H, m), 2.68 (1H, m), 2.78 (0.9H, s), 2.92-3.13 (3H, m), 2.93 (2.1H, s), 3.21-3.43 (2H, m), 3.67-3.82 (2H, m), 3.92-3.98 (1H, m), 4.38 (0.3H, m), 4.57 (0.3H, m), 4.61 (0.7H, d, J=3.4 Hz), 4.98 (0.7H, m), 6.29 (0.7H, br s, OH), 6.57 (1H, d, J=8.3 Hz), 6.63 (0.3H, br s, OH), 6.72 (0.3H, d, J=8.3 Hz), 6.74 (0.7H, d, J=8.3 Hz), 6.97 (0.6H, d, J=8.3 Hz) 7.00 (1.4H, d, J=8.3 Hz), 7.16 (1.4H, d, J=8.3 Hz), 7.20 (0.6H, d, J=8.3 Hz), 8.53 (2.8H, br s, NH3+), 8.84 (0.8H, m, NH+), 9.30 (0.3H, br s, OH), 9.33 (0.7H, br s, OH).

IR (KBr)

υ 3370, 1620, 1510, 1466, 1321, 1120, 1038, 919, 804 cm⁻¹.

Mass (FAB)

m/z 490 ((M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₄.1.6HCl.0.8H₂O

Calcd.: C, 61.94; H, 6.85; N, 7.47; Cl, 10.09.

Found.: C, 62.09; H, 7.02; N, 7.15; Cl, 9.93.

Example 128

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-aminophenylacetamido)morphinan.1.1 tartrate 138 (yield: 90%) was obtained by following the procedure of example 127 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-nitrophenylacetamido) morphinan.hydrochloride 83 instead of the starting material of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-4-nitrophenylacetamido)morphinan.hydrochloride 87.

mp>160° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, m), 0.53 (2H, m), 0.92 (1H, m), 1.18-1.32 (2H, m), 1.48-1.53 (2H, m), 1.74 (1H, m), 2.14-2.38 (2H, m), 2.54 (1H, m), 2.63-2.84 (2H, m), 2.79 (0.9H, s), 2.90 (2.1H, s), 3.08 (1H, m), 3.26-3.41 (2H, m), 3.51-3.63 (3H, m), 3.60 (7H, br s, 4×OH, NH3+), 4.09 (0.3H, m), 4.11 (2H, s), 4.47 (0.3H, m), 4.56 (0.7H, d, J=3.4 Hz), 4.95 (0.7H, m), 6.37-6.56 (3H, m), 6.58-6.64 (1H, m), 6.62-7.00 (1H, m), 9.10 (1H, br s, NH+).

IR (KBr)

υ 3312, 1736, 1719, 1609, 1510, 1460, 1402, 1309, 1267, 1120, 1069, 1038, 919, 774, 687 cm⁻¹.

Mass (FAB)

m/z 490 ((M+H)+).

Elementary Analysis: As C₂₉H₃₅N₃O₄.1.1C₄ H₆O₆1.8 H₂O. 0.5CH₃COOC₂ H₅

Calcd.: C, 58.15; H, 6.78; N, 5.75

Found.: C, 58.18; H, 6.76; N, 5.65

Example 129

17-Cyclopropylmethyl-3-acetoxy-4,5α-epoxy-14β-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan.hydrochloride 139

152 mg of 17-cyclopropylmethyl-4, 5α-epoxy-3,14βdihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan.hydrochloride 1 obtained in example 11 was dissolved in 2.3 ml of pyridine followed by the addition of 0.04 ml of acetic anhydride and stirring for 30 minutes. After concentrating the reaction solvent and removing the pyridine by azeotrope with toluene, the residue was washed with ether to obtain 148 mg of the target compound (yield: 91%).

mp>187° C. (decomposition)

NMR (400 MHz, CDCl₃)

δ 0.35-0.58 (1.3H, m), 0.63-0.94 (2.7H, m),1.25-1.75 (5H, m), 2.26 (2.1H, s), 2.27 (0.9H, s), 2.47-2.70 (2H, m), 2.83 (0.9H, S), 2.85 (2.1H, s), 2.90-3.26 (4H, m), 3.27-3.60 (2H, m), 3.69 (1.4H, s), 3.71 (0.6H, s), 4.35-4.60 (1.3H, m), 4.75-4.83 (0.3H, m), 4.86 (0.7H, d, J=2.9 Hz), 5.18-5.28 (0.7H, m), 6.70 (1H, d, J=8.4 Hz), 6.72 (1H, brs), 6.87-6.93 (1H, m), 7.09 (0.7H, dd, J=8.3, 2.0 Hz), 7.30 (0.3H, dd, J=8.3, 2.0 Hz), 7.35 (0.7H, d, J=2.0 Hz), 7.40 (0.7H, d, J=8.3 Hz), 7.48 (0.3H, d, J=2.0 Hz), 7.56 (0.3H, d, J=8.3 Hz), 9.40-9.70 (1H, m).

IR (KBr)

υ 3380, 1765, 1636, 1626, 1475, 1458, 1224, 1201, 1122, 1036 cm⁻¹.

Mass (FAB)

m/z 585 (M+H)+.

Elementary Analysis: As C₃₁H₃₄N₂O₅Cl₂.HCl

Calcd.: C, 59.86; H. 5.67; N, 4.50; Cl, 17.10

Found.: C, 59.71; H, 5.70; N, 4.55; Cl, 16.95

Examples 130-131

δ 17-Cyclopropylmethyl-3-acetoxy-14β-hydroxy-4,5α-epoxy-6β-(N-methylcinnamamido)morphinan.tartrate 140 (yield: 70%) and 17-cyclopropylmethyl-3-acetoxy-14β-hydroxy-4,5α-epoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan.tartrate 141 (yield: 56%) were obtained by following the procedure of example 129 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylcinnamamido)morphinan.tartrate 99 and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-trifluoromethylcinnamamido)morphinan.tartrate 60 instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido)morphinan.hydrochloride 1

Compound 140

mp 142-146° C. (decomposition, ethylacetate)

PNMR (400 MHz, DMSO-d₆)

δ 0.23 (2H, br s), 0.54 (2H, m), 0.92 (1H, m), 1.30 (1H, m), 1.38-1.50 (2H, m), 1.60 (1H, m), 1.85 (1.73H, s), 2.09-2.26 (2H, m), 2.21 (1.27H, s), 2.33 (1H, m), 2.60-4.40 (5H, br OH×5), 2.69 (1H, m), 2.78 (2H, m) 2.90 (1.73H, s), 3.13 (1.27H, s), 3.30 (1H, m), 3.33 (1H, m), 3.72 (1H, m), 3.89 (1H, m), 4.13 (2 H, s), 4.78 (0.67H, d, J=7.8 Hz), 5.00 (0.33 H, d, J=8.3 Hz), 6.72-7.72 (9H, m)

IR ( KBr)

υ 3350, 1760, 1640, 1600, 1493, 1309, 1189 cm⁻¹.

Mass (FAB)

m/z 529 (M+H)+.

Elementary Analysis: AS C₃₆ H₄₂N₂O₁₁

Calcd.: C, 63.71; H, 6.24; N, 4.13.

Found.: C, 63.51; H, 6.37; N, 4.10.

Compound 141

mp 125-128° C.

NMR (400 MHz, DMSO-d₆)

δ 0.22 (2H, brs), 0.53 (2H, m), 0.91 (1H, m), 1.3-1.7 (4H, m), 1.76 (2 H, br s), 2.1-2.2 (2H, m), 2.21 (1H, s), 2.35 (1H, m) 2.46 (1H, m), 2.6-2.8 (3H, m), 2.91 (2H, s), 3.15 (1H, s), 3.2-3.9 (3H, m), 4.12 (1.4H, s), 4.75 (0.7H, d, J=7.3 Hz), 5.00 (0.3H, d, J=8.3 Hz), 6.7-7.9 (2.7H, m), 7.36 (0.3H, d, J=15.6 Hz), 7.5-7.7 (2H, m), 7.71 (1H, d, J=7.3 Hz), 7.80 (0.7H, d, J=7.8 Hz), 7.92 (0.7H, s), 8.01 (0.3H, d, J=7.8 Hz), 8.14 (0.33H, s).

IR(KBr)

υ 3400, 1765, 1648, 1605, 1336, 1127 cm⁻¹.

Mass (FAB)

m/z 597 (M+H).

Elementary Analysis: As C₃₃ H₃₅N₂O₅F₃.0.70(C₄H₆O₆). 1.0H₂O

Calcd.: C, 59.74; H, 5.77; N, 3.89; F, 7.92.

Found.: C, 59.83; H. 5.82; N. 3.88; F, 7.88.

Example 132

17-cyclopropylmethyl-4, 5α-epoxy-14β-hydroxy-3-methoxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan.tartrate 142

245 mg of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan (free base of 1) obtained in example 11 was dissolved in 3.5 ml of chloroform followed by the addition of an excess amount of diazomethane and stirring for 1 hour. After concentrating the reaction system, the residue was purified with silica gel column chromatography (20 g hexane/ethylacetate/methanol/aqueous ammonia=5/3/0.2/0.04) to obtain the free base of the target compound. After dissolving this in methanol, 11 mg of tartaric acid was added to completely dissolve followed by concentration. The residue was re-precipitated from ether followed by filtration to obtain 83 mg of the target compound (yield: 30%).

mp>115° C. (decomposition)

NMR(400 MHz, DMSO-d₆+D20)

δ 0.15-0.33 (2H, m), 0.48-0.63 (2H, m), 0.87-1.00 (1H, m), 1.05-1.55 (4H, m), 1.69-1.85 (1H, m), 2.20-2.45 (2H, m), 2.55-2.95 (3H, m), 2.79 (0.9H, s), 2.94 (2.1H, s), 3.08-3.22 (1H, m), 3.30-3.58 (2H, m), 3.78 (3H, s), 3.77 (1H, d, J=16.1 Hz), 3.84 (1H, d, J=16.1 Hz), 4.09 (2H, s), 4.38-4.45 (0.3H, m), 4.55-4.63 (0.3H, m), 4.60 (0.7H, d, J=3.4 Hz), 4.88-4.96 (0.7H, m), 6.68 (0.7H, d, J=8.3 Hz), 6.64-6.70 (0.3H, m), 6.86 (0.7H, d, J=8.3 Hz), 6.82-6.88 (0.3H, m), 7.24 (0.7H, dd, J=8.3, 2.0 Hz), 7.24-7.30 (0.3H, m), 7.52 (0.7H, d, J=2.0 Hz), 7.52-7.56 (0.3H, m), 7.57 (0.7H, d, J=8.3 Hz), 7.60 (0.3H, d, J=8.3 Hz).

IR (KBr)

υ 3324, 1628, 1402, 1309, 1267, 1131 cm⁻¹.

Mass (II)

m/z=556 M+.

Elementary Analysis: As C₃₀H₃₄N₂O₄Cl₂.0.87C₄H₆O₆0.7H₂O

Calcd.: C 57.39; H 5.80; N 4.00; Cl 10.12

Found.: C 57.35; H 5.91; N 4.09; Cl 10.19

Example 133

14β-Acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan.hydrochloride 143

443 mg of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan (free base of 1) obtained in example 11 was dissolved in acetic anhydride followed by stirring for 1 hour at 160° C. with an oil bath. After concentrating the reaction solvent, the acetic anhydride was completely removed by azeotrope with toluene. The residue was dissolved in 10 ml of methanol followed by the addition of 14 ml of 4% aqueous sulfuric acid and stirring for 18 hours. 10 ml of aqueous ammonia and 30 ml of chloroform were then added to the system to separate, and the aqueous layer was extracted twice with 15 ml of chloroform. The organic layer was concentrated after drying with anhydrous sodium sulfate and the residue was purified with silica gel column chromatography (45 g, chloroform/ethylacetate =2/1). This was then recrystallized from chloroform and methanol followed by derivation of the crystals into hydrochloride with methanol solution of hydrochloride to obtain 299 mg of the target compound (yield: 59%).

mp>190° C. (decomposition)

NMR (400 MHz, DMSO-d₆)

δ 0.35-0.73 (4H, m), 0.90-1.03 (1H, m), 1.05-1.75 (4H, m), 2.17 (2.25H, s), 2.24 (0.75H, s),2.30-2.62 (2H, m), 2.65-2.83 (1H, m), 2.80 (0.75H, s), 2.96 (2.25H, s), 2.90-3.15 (2H, m), 3.18-3.52 (3H, m), 3.79 (0.75H, d, J=16.1 Hz), 3.84 (0.75H, d, J=16.1 Hz), 3.93-4.07 (0.5H, m), 4.55-4.60 (0.25H, m), 4.72 (0.75H, d, J=3.4 Hz), 4.77-4.85 (1H, m), 5.26 (1H, d, J=6.4 Hz), 6.50 (0.25H, d, J=8.3 Hz), 6.61 (0.75H, d, J=8.3 Hz), 6.77 (1H, d, J=8.3 Hz), 7.19-7.25 (0.25H, m), 7.24 (0.75H, dd, J=8.3, 2.0 Hz), 7.49 (0.25H, d, J=2.0 Hz), 7.52 (0.75H, d, J=2.0 Hz), 7.58 (0.75H, d, J=8.3 Hz), 7.60 (0.25H, d, J=8.3 Hz), 9.20-9.47 (1H, m), 9.42 (0.25H, s), 9.43 (0.75H, s).

IR (KBr)

υ 3420, 1744, 1626, 1473, 1406, 1371, 1321, 1214, 1116, 1035 cm⁻¹.

Mass (EI)

m/z 584 M+.

Elementary Analysis: As C₃₁H₃₄N₂O₅Cl₂.HCl.0.2H₂O

Calcd.: C, 59.52; H, 5.70; N, 4.48; Cl, 17.00.

Found.: C, 59.40; H, 5.90; N, 4.56; Cl, 17.12.

Example 134

17-Cyclopropylmethyl-3-hydroxy-14β-acetoxy-4,5α-epoxy-6β-(N-methylcinnamamido)morphinan.tartrate 144 (yield: 48%) was obtained by following the procedure of example 133 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methylcinnamamido)morphinan (free base of 99) instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methyl-3,4-dichlorophenylacetamido) morphinan (free base of 1).

mp 154-157° C.

NMR (400 MHz DMSO-d₆)

δ 0.06 (2H, m), 0.42 (2H, d, J=8.3 Hz), 0.72 (1H, m), 1.2-1.4 (3H, m), 1.93 (1H, m), 2.05 (1H, m), 2.11 (3H, s), 2.24 (1H, m), 2.37 (2H, m), 2.43 (1H, m), 2.62 (1H, m), 2.89 (2H, s), 3.03 (1H, d, J=18.1 Hz), 3.15 (1H, s), 3.2-3.4 (1H, m) 3.69 (0.7H, m), 4.15 (0.3H, m), 4.28 (1H, s), 4.70 (0.7H, d, J=7.8 Hz), 4.82 (0.3H, d, J=8.3 Hz), 6.5-6.8 (3H, m), 7.1-7.5 (5.3H, m), 7.71 (0.7H, d, J=6.3 Hz)

IR (KBr)

υ 3390, 1738, 1647, 1590, 1408, 1122 cm⁻¹.

Mass (FAB)

m/z 529 (M+H).

Elementary Analysis: As C₃₂ H₃₆N₂O₅.0.5(C₄H₆O₆).1.0H₂O

Calcd.: C, 65.68; H, 6.65; N, 4.50.

Found.: C, 65.85; H, 6.66; N, 4.43.

Example 135

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β(N-methyl-3-aminocinnamamido)morphinan.hydrochloride 145

360 mg of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-nitrocinnamamido)morphinan (free base of 104) and 1.07 g of stannic chloride dihydrate was dissolved in 7.5 ml of ethanol followed by heating to 70°0 C. and stirring for 2 hours. After cooling the reaction mixture to room temperature, 2 N aqueous sodium hydroxide was added while cooling with ice to neutralize followed by extraction with dichloromethane. The organic layers were combined and washed with saturated brine. After drying and concentrating, the organic substances were removed by chromatographic filtration [silica gel; chloroform:methanol (9:1)]. The resulting crude target compound was converted into a dihydrochloride to obtain 310 mg.

Mass (FAB)

m/z 502 ( (M+H)+).

Example 136

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-isothiocyanatocinnamamido)morphinanan. methanesulfonate 146

300 mg of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-aminocinnamamido)morphinan. hydrochloride 145 obtained in example 135 was dissolved in 9 ml of water and cooled with ice. 40 μl of thiophosgene dissolved in 2 ml of chloroform was added dropwise followed by stirring for 5 hours at warming to room temperature. Saturated aqueous sodium bicarbonate was then added to neutralize while cooling with ice followed by extraction with chloroform. The organic layers were combined and washed with saturated brine followed by drying and concentrating. The resulting residue was purified with column chromatography [silica gel; chloroform:methanol (97.5:2.5)], to obtain 208 mg of the resulting target compound after converting a methanesulfonate from (yield: 52% 2 steps).

mp 170° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.42 (1H, m), 0.49 (1H, m), 0.60 (1H, m), 0.69 (1H, m), 1.07 (1H, m), 1.27-1.58 (3H, m), 1.72 (1H, m), 2.11 (1H, m), 2.31 (3H, s), 2.43-2.52 (2H, m), 2.86 (1H, m), 2.92 (2.1H, s), 3.02-3.14 (2H, m), 3.18 (0.9H, s), 3.30-3.38 (2H, m), 3.70 (0.7H, m), 3.83 (1H, m), 4.19 (0.3H, m), 4.80 (0.7H, d, J=8.3 Hz), 4.90 (0.3H, d, J=8.3 Hz), 6.14 (0.3H, br s), 6.22 (0.7H, br s), 6.65-6.84 (2.1H, m), 6.88 (0.7H, d, J=7.8 Hz), 7.29 (1H, d, J=15.6 Hz), 7.40-7.50 (3.6H, m), 7.69 (0.3H, d, J=7.8 Hz), 7.91 (0.3H, S), 8.74 (1H, br s), 9.30 (0.3H, br s), 9.54 (0.7H, br s).

IR (KBr)

υ 3380, 3210, 2124, 1649, 1599, 1197, 1060, 785 cm⁻¹.

Mass (FAB)

m/z 544 ((M+H)+).

Elementary Analysis: As C₃₁H₃₃N₃O₄S.CH₃SO₃H.H₂O

Calcd.: C, 58.43; H, 5.98; N, 6.39; S, 9.75

Found.: C, 58.67; H, 6.15; N, 6.11; S, 9.78

Example 137

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-aminocinnamamido)morphinan.hydrochloride 147 was obtained by following the procedure of example 135 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-nitrocinnamamido)morphinan (free base of 97) instead of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-nitrocinnamamido)morphinan (free base of 104).

Mass (FAB)

m/z 502 ( (M+H)+).

Examples 138-139

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-isothiocyanatocinnamamido)morphinan. methanesulfonate (yield: 32% 2 steps) 148 and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-isothiocyanatophenylacetamido)morphinanan. methanesulfonate 149 (yield: 78%) were obtained by following the procedure of example 136 but using 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-aminocinnamamido)morphinan.hydrochloride 147 and 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(N-methyl-3-aminophenylacetamido)morphinan.hydrochloride 138 instead of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(N-methyl-3-aminocinnamamido)morphinan.hydrochloride 145.

Compound 148

mp 160° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.41 (1H, m), 0.48 (1H, m), 0.62 (1H, m), 0.70 (1H, m), 1.05 (1H, m), 1.20 (1H, m), 1.40-1.67 (3H, m), 1.93 (1H, m), 2.31 (3.3H, s), 2.47 (1H, m), 2.71 (1H, m), 2.91 (0.6H, s), 2.93 (1H, m), 3.01-3.15 (2H, m), 3.10 (2.4H, s), 3.25-3.38 (2H, m), 3.89 (1H, br d, J=5.9 Hz), 4.58 (0.2H, m), 4.73 (0.8H, d, J=3.4 Hz), 4.94 (0.2H, br s), 5.04 (0.8H, m), 6.20 (0.8H, s), 6.25 (0.2H, br s), 6.61 (1H, d, J=7.8 Hz), 6.72 (1H, d, J=7.8 Hz), 7.22 (0.2H, d, J=14.1 Hz), 7.37 (0.8H, d, J=15.6 Hz), 7.42-7.54 (3H, m), 7.68 (0.2H, d, J=7.3 Hz), 7.71 (0.8H, d, J=7.3 Hz), 7.77 (0.2H, s), 7.93 (0.8H, s), 8.77 (1H, br s), 9.30 (1H, br s).

IR (KBr)

υ 3340, 3200, 2112, 1649, 1599, 1508, 1460, 1210, 1195, 1118, 1060, 1038, 785 cm⁻¹.

Mass (FAB)

m/z 544 ((M+H)+.

Elementary Analysis: As C₃₁H₃₃N₃O₄S.1.CH₃SO₃H.H₂O

Calcd.: C 57.77; H 5.95; N 6.29; S 10.09

Found.: C 57.72; H 6.04; N 6.22; S 10.22

Compound 149

mp>155° C. (decomposition)

NMR (500 MHz, DMSO-d₆)

δ 0.38 (1H, m), 0.46 (1H, m), 0.61 (1H, m), 0.70 (1H, rm), 1.04 (1H, m), 1.15 (1H, m), 1.36 (1H, m), 1.55 (1H, m), 1.62 (1H, m), 1.89 (1H, m), 2.30 (3H, s), 2.42 (1H, m), 2.71 (1H, m)), 2.93 (1H, m), 2.96 (3H, s), 3.03 (1H, m), 3.10 (1H, m), 3.23-3.37 (2H, m), 3.73-3.90 (3H, m), 4.44 (0.1H, m). 4.63 (0.9H, d, J=3.7 Hz), 4.71 (0.1H, m), 4.98 (0.9H, ddd, J=14.3, 4.0, 4.0 Hz), 6.12 (0.9H, s, OH), 6.23 (0.1H, s, OH), 6.59 (1H, d, J=8.3 Hz), 6.71 (1H, d, J=8.3 Hz), 7.01-7.44 (4H, m), 8.75 (1H, m, NH+), 9.27 (1H, s, OH).

IR (KBr)

υ 3258, 2122, 1736, 1625, 1613, 1460, 1402, 1323, 1207, 1160, 1120, 919, 775 cm⁻¹.

Mass (FAB)

m/z 532 ((M+H)+).

Elementary Analysis: As C₃₀H₃₃N₃O₄S.CH₃SO₃H.0.9 H₂O

Calcd.: C 57.82; H 6.07; N 6.52; S 9.96

Found.: C 58.21; H 6.22; N 6.40; S 9.58

Example 140 Opioid Activity Test Using the Isolated Guinea Pig Preparation Preparation

A male Hartley guinea pig was used in this test.

After sacrificing the guinea pig and extracting the ileum, the lumen was washed with nutrient solution and only the longitudinal muscle was isolated. This longitudinal muscle was filled with Krebes-Henseleit solution (NaCl 118 mM; KCl 4.7 mM; CaCl₂ 2.5 mM; KH₂PO₄1.2 mM; NaHCO₃ 25 mM; MgSO₄ 1.2 mM and glucose 10 mM) warmed to 37° C. and suspended in a Magnus tube ventilated with 5% carbon dioxide and 95% oxygen. Electrical stimulus was performed at 0.1 Hz for 5.0 ms by means of ring-shaped platinum electrodes located above and below. Tissue contractions were recorded on a polygraph using an isometric transducer.

Initially, the test drug was cumulatively added to a concentration at which specimen contractions caused by electrical stimulus were suppressed by 50% to calculate the IC₅₀ value. Then after adequately washing with nutrient solution and the contraction reaction stabilized, naloxone, a μ antagonist, or norBNI, a κ agonist, were added and the test compound was again cumulatively added after roughly 20 minutes. The Ke value was calculated using the following calculation formula from the difference in the efficacies of both agonists.

Ke=[Conc. of added antagonist]/(IC₅₀ ratio−1)

IC₅₀ ratio=IC₅₀ in the presence of antagonist/IC₅₀ in the absence of antagonist

As a result, when the ratio between the Ke value (μ) and Ke value (κ) was taken, Ke(μ)/Ke(κ)=4063. It was thus found that the compounds of the present invention are highly selective agonists for κ receptors.

Ke (nM) IC₅₀ (nM) Naloxone norBNI 1 0.026 650 0.16

Example 141 Opioid Activity Test Using the Isolated Mouse Vas Deference Preparation

A male ddy mouse was used in this test. The isolated vas deference was filled with Krebes-Henseleit solution (NaCl 118 mM; KCl 4.7 mM; CaCl₂ 2.5 mM; KH₂PO₄ 1.1 mM; NaHCO₃ 25 mM; and glucose 10 mM) warmed to 37° C. and suspended in a Magnus tube ventilated with 5% carbon dioxide and 95% oxygen. Electrical stimulus was performed at 0.1 Hz for 5.0 ms by means of ring-shaped platinum electrodes located above and below. Tissue contractions were recorded on a polygraph using an isometric transducer.

Initially, the test drug was cumulatively added to a concentration at which specimen contractions caused by electrical stimulus were suppressed by 50% to calculate the IC₅₀ value. Then after adequately washing with nutrient solution and the contraction reaction stabilized, naloxone, a μ agonist, NTI, a δ agonist, or norBNI, a κ agonist, were added and the test compound was again cumulatively added after roughly 20 minutes. The Ke value was calculated using the following calculation formula from the difference in the efficacies of both agonists.

Ke=[Conc. of added agonist]/(IC₅₀ ratio−1)

IC₅₀ ratio IC₅₀ in the presence of agonist/IC₅₀ in the absence of agonist

A portion of the evaluation results of the compounds of the present invention are shown in Table 1. In each cases, there are no large differences in IC₅₀ values before and after use of naloxone, and agonist activity by means of p receptors was found to be extremely weak. Namely, compounds 24, 84, 96, 97, 126 are selective agonists for δ receptors, while compounds 1, 22, 38, 39, 42, 43, 45, 46, 47, 52, 57, 59, 60, 61, 62, 63, 68, 69, 70, 73, 89, 91, 98, 99, 100, 101, 102, 103, , 122, 140 and 141 are selective agonists for κ receptors.

TABLE 1 Opioid Activity of Compounds Ke (nM) IC₅₀ (nM) Naloxone NTI norBNI  1 0.395 53 17.3 0.548 22 1.20  800 545 5.53 24 0.121 16.5 0.426 4.90 38 0.349 411 16.6 4.65 39 0.568 89.9 99.3 1.01 42 0.251 186 63.5 0.905 43 0.650 409 22.5 5.31 45 0.185 26.5 135 0.416 46 1.05  — — 0.440 47 0.439 63.5 10.4 0.140 53 10.3   — 1676 0.21 57  0.0254 — 747 0.0124 59 1.14  21.3 47.3 0.151 60 0.468 — 291 3.20 61 0.420 14000 41.6 0.164 62 14.7   — 90.2 0.203 63 0.746 60.9 96.9 1.60 68 0.457 5710 143 1.08 69 0.320 1780 64.5 1.95 70 0.545 — — 0.198 73 0.072 524 78 0.272 84 2.07  35.4 0.309 5.69 89  0.0934 18.3 15.6 0.85 91 0.378 — 450 0.699 96 0.346 32.5 1.61 4.21 97 0.247 163 2.92 13.9 98 1.30  — — 1.35 99 0.674 94.5 — 0.652 100  0.647 1797 — 0.0717 101  0.269 25.4 31.6 0.0425 102  1.60  — 276 2.37 103  11.0   — — 0.657 104  0.227 185 89 1.40 122  3.01  59.5 42.7 0.358 126  0.969 40.2 0.0065 1.20 140  0.413 320 261 1.06 141  0.160 142 184 1.39

Example 142 Analgesic Activity Test Using the Acetic Acid-induced Writhing Method

5 week old ddY mice were used in this test. After intraperitoneal administration of 0.1 ml of 0.6% aqueous acetic acid per 10 g of body weight, the number of writhing reactions that occurred in 10 minutes starting 10 minutes after administration was evaluated for the indicator. The test drug was administered subcutaneously into the backs of the animals 15 minutes before administration of acetic acid. A portion of those results are shown in Table 2. In this test, compounds 42, 47, 63 and 96 demonstrating ED₅₀ values of 0.00136, 0.00052, 0.0011 and 0.00086 mg/Kg, respectively, indicating particularly strong analgesic activity.

TABLE 2 Analgesic Activity According to Acetia Acid Writhing Compound ED₅₀ (mg/kg) Compound ED₅₀ (mg/kg)  1 0.017 22 0.0051 23 0.67 24 0.00575 26 0.099 27 0.046 28 0.071 31 0.75 32 0.290 33 0.080 34 0.210 35 0.026 36 0.23 37 0.0041 38 0.00352 39 0.0088 41 0.39 42 0.00136 43 0.0055 44 0.084 45 0.0038 46 0.013 47 0.00052 48 0.019 49 0.026 50 0.011 51 0.19 53 0.46 54 0.72 55 0.980 56 0.00802 57 0.040 58 0.190 59 0.0028 60 0.0046 61 0.0044 62 0.077 63 0.0011 64 0.097 65 0.15 67 0.36 68 0.0042 69 0.0049 70 0.0016 71 0.0042 72 0.18 73 0.023 74 0.78 83 0.0080 84 0.0058 85 0.1128 86 0.0347 87 0.027 89 0.00471 91 0.019 94 0.013 95 0.0081 96 0.00086 97 0.0019 98 0.0068 99 0.0018 100  0.024 101  0.0066 102  0.0019 103  0.069 104  0.017 105  0.098 106  0.25 107  0.023 108  0.0064 122  0.34 128  0.63 132  0.073 133  0.044 134  0.15 137  0.170 138  0.014 139  0.040 140  0.0034 141  0.010 142  0.78 144  0.024 149  0.013 Morphine 0.55

Example 143 Evaluation of Diuretic Action

7-8 week old male Wistar rats were used in this test after prohibiting from drinking water for 1 hour before testing. After discharging any urine accumulated in the bladder by gently stimulating the lower abdomens of the animals, the drug was administered subcutaneously. After 30 minutes, the animals were then forcibly given 20 ml/kg of physiological saline orally. The animals were then placed in metabolic cages immediately after administration of the drug (2 animals/cage) and urine output for 5 hours after loading with physiological saline was measured. Drug efficacy was expressed in the form of those doses resulting in urine outputs of 200 and 500, respectively, when the urine output of a non-dosed group was taken to be 100. Those doses were expressed as the ED₂₀₀ and ED₅₀₀ values, respectively. A portion of those results are shown in Table 3. In this test, the ED₂₀₀ values of compounds 22, 24, 42 and 43 were 0.00095, 0.00069, 0.00085 and 0.00054 mg/kg, respectively, indicating that these compounds have extremely strong diuretic action.

TABLE 3 Diuretic Action ED500 ED500 Compound ED200 (mg/kg) Compound ED200 (mg/kg)  1 0.0027 0.0457 22 0.00095 0.0170 24 0.00069 0.0063 27 0.0248 2.075 28 0.0200 3.799 35 0.0245 5.19 37 0.365 — 38 0.0038 0.281 39 0.0041 0.228 42 0.00085 0.0061 43 0.00054 0.0044 45 0.0081 0.857 47 0.0016 — 50 0.0021 0.0325 53 0.135 0.658 56 0.0028 0.0518 57 0.0424 1.256 59 0.0105 2.364 60 0.0143 1.13 61 0.0032 0.157 62 0.101 7.04 63 0.0038 0.309 65 0.119 5.31 68 0.0016 0.0232 83 0.0261 2.99 84 0.0028 0.0469 86 0.0057 0.229 89 0.0012 0.0162 91 0.0094 0.960 95 0.0028 0.0968 96 0.0013 0.0549 97 0.0045 0.0939 98 0.0065 0.206 99 0.0011 0.0309 100  0.0159 0.811 101  0.0089 0.226 102  0.0014 0.0154 103  0.0827 5.65 105  0.0190 3.30 107  0.0061 0.20 108  0.0210 5.11 141  0.0319 3.45

Industrial Applicability

AS a result of in vitro and in vivo tests, the compounds of the present invention were found to have both strong analgesic and diuretic activity as κ-agonists. It was clear that said compounds can be expected to be useful as analgesics and diuretics. Based on the properties of κ-agonists, the compounds of the present invention can also be used as hypotensives and sedatives. 

What is claimed is:
 1. A morphinan derivative represented by the formula (I) or its pharmacologically acceptable acid addition salt:

wherein, represents a single or double bond; R¹ represents an alkyl group having 1-5 carbon atoms, a cycloalkylalkyl group having 4-7 carbon atoms, a cycloalkenylalkyl group having 5-7 atoms, an aryl group having 6-12 carbon atoms, an aralkyl group having 7-13 carbon atoms, an alkenyl group having 4-7 carbon atoms, an allyl group, a furan-2-ylalkyl group having 1-5 alkyl carbon atoms, or a thiophen-2-ylalkyl group having 1-5 alkyl carbon atom; R² represents a hydrogen atom, a hydroxy group, a nitro group, an alkanoyloxy group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, or —NR⁹R¹⁰; R⁹ represents a hydrogen atom or an alkyl group having 1-5 carbon atoms; R¹⁰ represents a hydrogen atom, an alkyl group having 1-5 carbon atoms or —C(═O)R¹¹; R¹¹ represents a hydrogen atom, a phenyl group or an alkyl group having 1-5 carbon atoms, R³ represents a hydrogen atom, a hydroxy group, an alkanoyloxy group having 1-5 carbon atoms or an alkoxy group having 1-5 carbon atoms; A represents —NR^(4′)C(═Y)—, —NR⁴C(═Y)Z—, —NR^(4′)SO₂—, —NR^(4′)—, or —OC(OR⁴)R⁴— where Y and Z each independently represent NR⁴, S or O, R⁴ represents a hydrogen atom, a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms, and wherein R⁴ may be identical or different, and R^(4′) represents a hydrogen atom, a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms, B represents a valence bond, a straight-chain or branched alkylene group having 1-14 carbon atoms which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight chain or branched acyclic unsaturated hydrocarbon containing 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds having 1-14 carbon atoms wherein no heteroatom is bonded directly to A; R⁵ represents a hydrogen atom or an organic group having the structure below which may be substituted with one or more substituent groups selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, an isothiocyanate group, a trifluoromethyl group and a methylenedioxy group;

wherein Q is N, O or S, T is CH, N, S or O, 1 is 0-5, m, n≧0 and m+n≦5; R⁸ represents a hydrogen atom, an alkyl group having 1-5 carbon atoms or an alkanoyl group having 1-5 carbon atoms; with proviso that a) when A represents —NR^(4′)C(═Y)—, —NR^(4′)C(═Y) Z—or —NR⁴ SO₂—, and NR⁴ represents a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms, then R¹ represents an alkyl group having 1-2 carbon atoms, a cycloalkenylalkyl group having 5-7 carbon atoms, an aryl group having 6-12 carbon atoms, an aralkyl group having 7-13 carbon atoms, a furan-2-ylalkyl group having 1-5 carbon atoms or thiophen-2-ylalkyl group having 1-5 carbon atoms; b) when A represents —NHC(═0)—, and R⁵ represents a hydrogen atom, then B represents a straight-chain or branched alkylene having 3-14 carbon atoms (which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, trifluoromethyl group and a phenoxy group), a straight-chain or branched acyclic unsaturated hydrocarbon containing 1 to 3 double bonds and/or triple bonds and having 3-14 carbon atoms, which may be substituted with one or more substituents selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds having 1-14 carbon atoms wherein no heteratom is bonded directly to A; c) when A represents —NHC(═O)—, B presents a valence bond, and R⁵ represents a phenyl group, then R⁵ must be substituted with at least one substitutent selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, an isothiocyanate group, a trifluoromethyl group and a methylenedioxy group; d) when A represents —NH—, and R⁵ represent a hydrogen atom, then B represents a straight-chain or branched alkylene group having 3-14 carbon atoms, which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight-chain or branched acyclic unsaturated hydrocarbon containing 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms, which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thieoether, ether and/or amino bonds having 1-14 carbon atoms wherein no heteroatom is bonded directly to A; e) when A represents —NH—, B represents a straight-chain alkylene having one carbon atom, and R⁵represents a phenyl group, then R⁵ must be substituted with one or more substituents selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, an isothiocyatate group, a trifluoromethyl group and a methylenedioxy group; and f) when A represents —NR^(4′)—, R^(4′) represents a straight-chain alkyl group having 1 or 2 carbon atoms, and R⁵ represents a hydrogen atom, when B represents a straight-chain or branched alkylene group having 3-14 carbon atoms, which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight-chain or branched acyclic unsaturated hydrocarbon containing 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms, which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds having 1-14 carbon atoms wherein no heteroatom is bonded to A; and formula (I) includes the (+) form, (−) form and (±)form.
 2. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —NR^(4′)C(═Y)Z—, —OC(OR⁴)R⁴— or —SSO₂—, provided that Z represents NR⁴ or S when Y is O.
 3. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —NR⁴ C(═Y)—, wherein Y represents NR⁴ or S.
 4. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —N^(4′)C(═S)NR⁴—, NR^(4′)C(═O)NR⁴, —NR^(4′)C(═O)O—, —NR^(4′)C(═O)—, —NR^(4′C(═S)—or —NR) ^(4′)SO₂—, wherein R⁴ and R^(4′) independently, represent a straight chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms:


5. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —N^(4′)C(═O)O— provided that, when p^(4′)and R⁵ are both hydrogen atoms, B represents a straight-chain or branched alkylene group having 3-14 carbon atoms, which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight chain or branched acylic unsaturated hydrocarbon containing from 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms which may be substituted with one or more substitution groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds and having 1-14 carbon atoms, wherein no hetero atom is bonded directly to A.
 6. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —NHC(═O)—, B is a straight-chain or branched alkylene group having 1-14 carbon atoms which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight chain or branched acyclic unsaturated hydrocarbon containing from 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds and having 1-14 carbon atoms, wherein no hetero atom is bonded directly to A, and R⁵ is an organic group having the following structure:

wherein Q is N. O or S. T is CH, N. S or O, l is 0-5, m, n≧0 and m+n≦5; which may be substituted by at least one type of substituent group selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, an isothiocyanato group, a trifluoromethyl group and a methylenedioxy group.
 7. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —NHC(═O)—, B represents a valence bond, and R⁵ is an organic group having the following structure:

wherein Q is N, O or S, T is CH, N, S or O, l is 0-5, m, n≧0 and m +n≦5; wherein R⁵ is substituted by at least one type of substituent group selected from the group consisting of an alkyl group having 1-5 carbon atoms, an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, chlorine, bromine, iodine, an amino group, a nitro group, a cyano group, an isothiocyanato group, a trifluoromethyl group and a methylenedioxy group.
 8. The compound of claim 6, or its pharmacologically acceptable acid addition salt, wherein R¹ is a methyl, ethyl, cyclopropylmethyl, allyl, benzyl or phenethyl group, and R² and R³ are independently a hydrogen atom, a hydroxy, acetoxy or methoxy group, and R⁸ is a hydrogen atom or methyl group.
 9. The compound of claim 4, or its pharmacologically acceptable acid addition salt, wherein A is —NR^(4′)C(═O)—and wherein R⁴ represents a straight-chain or branched alkyl group having 1-5 carbon atoms or an aryl group having 6-12 carbon atoms.
 10. The compound of claim 1, or its pharmacologically acceptable acid addition salt, wherein A is —NR^(4′)—, and provided that, when R⁵ is a hydrogen atom, B is a straight-chain or branched alkylene group having 5-14 carbon atoms which may be substituted with one or more types of substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, a straight-chain or branched acyclic unsaturated hydrocarbon containing from 1 to 3 double bonds and/or triple bonds and having 2-14 carbon atoms which may be substituted with one or more substituent groups selected from the group consisting of an alkoxy group having 1-5 carbon atoms, an alkanoyloxy group having 1-5 carbon atoms, a hydroxy group, fluorine, a nitro group, a cyano group, a trifluoromethyl group and a phenoxy group, or a straight-chain or branched saturated or unsaturated hydrocarbon containing from 1 to 5 thioether, ether and/or amino bonds and having 1-14 carbon atoms wherein no hetero atom is bonded directly to A.
 11. A pharmaceutical composition containing a morphinan derivative of claim 1, or a pharmacologically acceptable acid addition salt thereof, as an active ingredient.
 12. A method for producing analgesia comprising administering an effective amount of a pharmaceutical composition comprising a morphinan derivative of claim 1, or a pharmacologically acceptable acid addition salt thereof, as an active ingredient to a subject requiring pain relief.
 13. A method of diuresis comprising administering an effective amount of a pharmaceutical composition comprising a morphinan derivative of claim 1, or a pharmacologically acceptable acid addition salt thereof, as an active ingredient. 